Results 21 to 30 of about 81,861 (342)
Haematologica, 2010 Background Somatic mutation in the X-linked phosphatidylinositol glycan class A gene (PIG-A) causes glycosyl phosphatidylinositol anchor deficiency in human patients with paroxysmal nocturnal hemoglobinuria.Design and Methods We produced an animal model ...
Valeria Visconte +6 more
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A Concise Synthesis of a BODIPY-Labeled Tetrasaccharide Related to the Antitumor PI-88
Molecules, 2021 A convergent synthetic route to a tetrasaccharide related to PI-88, which allows the incorporation of a fluorescent BODIPY-label at the reducing-end, has been developed.
Juan Ventura +6 more
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BMC Chemistry, 2019 Flickingeria fimbriata is commonly applied in China as a traditional Chinese medicine (TCM), however the quality control of it is incomplete. In this work, we aim to identify and quantify the structures of C-glycosyl flavones in F. fimbriata.
Yawen Wang +7 more
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Ridge Regression Estimated Linear Probability Model Predictions of O-glycosylation in Proteins with Structural and Sequence Data [PDF]
BMC Molecular and Cell Biology 2019, 2018 The likelihood of O-GlcNAc glycosylation in human proteins is predicted using the ridge regression estimated linear probability model (LPM). To achieve this, sequences from three similar post-translational modifications (PTMs) of proteins occurring at, or very near, the S or T site are analyzed: N-glycosylation, O-mucin type (O-GalNAc) glycosylation ...
arxiv +1 more source
Anomeric O-Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs. [PDF]
, 2018 Carbohydrates mediate a wide range of biological interactions, and understanding these processes benefits the development of new therapeutics. Isolating sufficient quantities of glycoconjugates from biological samples remains a significant challenge ...
Gervay-Hague, Jacquelyn +2 more
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Synthesis and glycosidation of building blocks of D-altrosamine
Frontiers in Chemistry, 2022 Presented herein is a streamlined synthesis of building blocks of a rare sugar D-altrosamine. Also investigated was the glycosylation of different glycosyl acceptors with differentially protected altrosamine donors.
Mariya Novakova +4 more
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Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate [PDF]
, 2001 Hen egg-white lysozyme (HEWL) was the first enzyme to have its three-dimensional structure determined by X-ray diffraction techniques(1). A catalytic mechanism, featuring a long-lived oxo-carbenium-ion intermediate, was proposed on the basis of model ...
A Federov +28 more
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Beilstein Journal of Organic Chemistry, 2013 A series of glycosyl hemiacetal derivatives have been transformed into thioglycosides and glycosyl thiols in a one-pot two-step reaction sequence mediated by Appel reagent (carbon tetrabromide and triphenylphosphine).
Tamashree Ghosh +2 more
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Centralized Modularity of N-Linked Glycosylation Pathways in Mammalian Cells [PDF]
PLoS ONE 4, e7317 (2009), 2009 Glycosylation is a highly complex process to produce a diverse repertoire of cellular glycans that are attached to proteins and lipids. Glycans are involved in fundamental biological processes, including protein folding and clearance, cell proliferation and apoptosis, development, immune responses, and pathogenesis. One of the major types of glycans, N-
arxiv +1 more source
Beilstein Journal of Organic Chemistry, 2013 Glycosylations of 5-(1H-indol-2-yl)-1,3,4-oxadiazoline-2(3H)-thione delivered various degrees of S- and/or N-glycosides depending on the reaction conditions.
El Sayed H. El Ashry +5 more
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