Results 91 to 100 of about 175,061 (321)
Coding Synthetic Chemistry Strategies for Furan Valorization into Bacterial Designer Cells**
ChemSusChem, Volume 16, Issue 2, January 20, 2023., 2023 Designer cells: A microbial factory is designed to directly convert furfuryl alcohols to synthetically valuable and enantioenriched delta‐lactones. Pairing Achmatowicz ring expansions and borrowing hydrogen redoxisomerizations, two otherwise non‐natural transformations, this study highlights the potential of introducing novel biocatalytic tools into ...
Yu‐Chang Liu +2 more
wiley +1 more source
Advanced Science, EarlyView.Two closely related whitefly species, Trialeurodes vaporariorum and Bemisia tabaci, are found to each possess a plant‐derived TLP gene, but with entirely different functions. This finding of functional divergence challenges the notion that HGT genes maintain similar functions across species and shows that they can follow unique evolutionary paths that ...
Yuan Hu +12 more
wiley +1 more source
Electrophoretic detection of black market myostatin propeptide
Drug Testing and Analysis, Volume 14, Issue 11-12, Page 1812-1824, November-December 2022., 2022 Of the 12 black market products investigated, only nine contained the target protein among dozens of other proteins. In the remaining ones, small growth hormone‐related peptides were found by mass spectrometry (e.g., tesamorelin). A shotgun proteomics approach revealed that all nine products contained full length GST‐tags.
Christian Reichel +2 more
wiley +1 more source
AGING MEDICINE, EarlyView.ABSTRACT Purpose Premature cellular senescence is a pivotal process in aging and age‐related diseases, triggered by various stressors. However, this is not a homogeneous phenotype, but a heterogeneous cellular state composed of multiple senescence programs with different compositions. Therefore, understanding the complex dynamics of senescence programs
Vinícius Pierdoná +6 more
wiley +1 more source
Bayesian Profiling Multiple Imputation for Missing Electronic Health Records [PDF]
arXiv, 2019 Electronic health records (EHRs) are increasingly used for clinical and comparative effectiveness research, but suffer from missing data. Motivated by health services research on diabetes care, we seek to increase the quality of EHRs by focusing on missing values of longitudinal glycosylated hemoglobin (A1c), a key risk factor for diabetes ...
arxiv
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Cystic kidney diseases (CyKD) are a diverse group of disorders affecting more than 1 in 1000 individuals. Over 120 genes are implicated, primarily encoding components of the primary cilium, transcription factors, and morphogens. Prognosis varies greatly by molecular diagnosis. Causal variants are not identified in 10%–60% of individuals due to
Deborah Watson +10 more
wiley +1 more source
Antigen targeting to dendritic cells: Still a place in future immunotherapy?
European Journal of Immunology, Volume 52, Issue 12, Page 1909-1924, December 2022., 2022 Dendritic cell‐based immunotherapy is a promising vaccination strategy to treat infectious diseases, autoimmunity, and cancer. In this review, we present an overview on the current state of antigen targeting approaches via C‐type lectin receptors, with an outlook on future developments and potential for clinical translation.
Patrizia Stoitzner +4 more
wiley +1 more source
Osmotic properties of polyethyleneglycols: quantitative features of brush and bulk scaling laws [PDF]
arXiv, 2002 From glycosylated cell surfaces to sterically stabilized liposomes, polymers attached to membranes attract biological and therapeutic interest. Can the scaling laws of polymer "brushes" describe the physical properties of these coats? We delineate conditions where the Alexander - de Gennes theory of polymer brushes successfully describes the ...
arxiv
Mucin-inspired, high molecular weight virus binding inhibitors show biphasic binding behavior to influenza A viruses [PDF]
arXiv, 2020 Multivalent virus binding inhibitors are a promising new class of antivirals, preventing virus infection of cells by inhibiting the first step in the viral infection cycle - binding of viruses to the cell surface. The design of multivalent virus binding inhibitors is complex as many properties, such as inhibitor size and functionalization with virus ...
arxiv
Novel Approaches To Design Glycan‐Based Antibacterial Inhibitors
European Journal of Organic Chemistry, Volume 26, Issue 1, January 2, 2023., 2023 Sweet and sticky: This review describes recent advances in the synthesis and application of homo‐and heterovalent glycan‐scaffolds as potential candidates for efficient bacteria lectin inhibition. To study and address the many complex molecular mechanisms involved in multivalent lectin binding events, novel glycoconjugate designs and fine‐tunable ...
Sandra Behren, Ulrika Westerlind
wiley +1 more source