Results 111 to 120 of about 175,061 (321)

Glycosylation in the tumor immune response: the bitter side of sweetness

Acta Biochimica et Biophysica Sinica
Glycosylation is the most structurally diverse form of post-translational modification (PTM) of proteins that affects a myriad of cellular processes. As a pivotal regulator of protein homeostasis, glycosylation notably impacts the function of proteins ...
Cao Yuting, Yi Wen, Zhu Qiang
doaj   +1 more source

Glycosylation of vesicular stomatitis virus glycoprotein in virus-infected HeLa cells [PDF]

, 1976
Lee Hunt, Donald F. Summers
openalex   +1 more source

Effect of impaired glycosylation on the biosynthesis of Semliki forest virus glycoproteins [PDF]

, 1975
G. Kaluza
openalex   +1 more source

Flux Sampling Suggests Metabolic Signatures of High Antibody‐Producing CHO Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells remain the industry standard for producing numerous therapeutic proteins, particularly monoclonal antibodies (mAbs). However, achieving higher recombinant protein titers remains an ongoing challenge and a fundamental understanding of the cellular mechanism driving improved bioprocess performance remains ...
Kate E. Meeson, Joanne Watson, Susan Rosser, Ellie Hawke, Andrew Pitt, Tessa Moses, Leon Pybus, Magnus Rattray, Alan J. Dickson, Jean‐Marc Schwartz   +9 more
wiley   +1 more source

Virus-Dependent Glycosylation [PDF]

, 1976
Bartholomew M. Sefton
openalex   +1 more source

Temporal Galactose‐Manganese Feeding in Fed‐Batch and Perfusion Bioreactors Modulates UDP‐Galactose Pools for Enhanced mAb Glycosylation Homogeneity

Biotechnology and Bioengineering, EarlyView.
This study investigates the temporal effects of galactose and manganese on the N‐glycosylation of Trastuzumab (mAb) antibody during fed‐batch and perfusion bioprocessing modes to reveal the influence of feeding schedules on mAb N‐glycosylation patterns. These findings will aid in building process control schemes for mAb bioprocessing.
Aron Gyorgypal, Erica Fratz‐Berilla, Casey Kohnhorst, David N. Powers, Shishir P. S. Chundawat   +4 more
wiley   +1 more source

The purification and identification of antioxidants and dipeptidyl peptidase IV inhibitory peptides from whey protein hydrolysates

Food Bioengineering, Volume 1, Issue 3-4, Page 298-306, December 2022., 2022
Whey protein was enzymatically hydrolyzed using an ultrahigh‐pressure synergistic enzymolysis method. The identified amino acid sequences were then synthesized, and their antioxidants and DPP‐IV inhibitory activities were determined. Whey protease hydrolysates could potentially be expected to be successfully commercially developed as functional ...
Zheng Yuanrong, Pang Jiakun, Liu Zhenmin
wiley   +1 more source

In silico evaluation of the role of Fab glycosylation in cetuximab antibody dynamics

Frontiers in Immunology
IntroductionN-glycosylation is a post-translational modification that is highly important for the development of monoclonal antibodies (mAbs), as it regulates their biological activity, particularly in terms of immune effector functions.
Simona Saporiti, Davide Bianchi, Omar Ben Mariem, Mara Rossi, Uliano Guerrini, Ivano Eberini, Fabio Centola   +6 more
doaj   +1 more source

The effect of tunicamycin on the glycosylation of lactating-rabbit mammary glycoproteins [PDF]

, 1979
Brian K. Speake, David A. White
openalex   +1 more source

Longitudinal Transcriptional Response of Glycosylation-Related Genes, Regulators, and Targets in Cancer Cell Lines Treated With 11 Antitumor Agents

Cancer Informatics, 2017
Cellular glycosylation processes are vital to cell functioning. In malignant cells, they are profoundly altered. We used time-course gene expression data from the NCI-60 cancer cell lines treated with 11 antitumor agents to analyze expression changes of ...
Julia Krushkal, Yingdong Zhao, Curtis Hose, Anne Monks, James H Doroshow, Richard Simon   +5 more
doaj   +1 more source