Results 181 to 190 of about 380,786 (407)

Primary structural requirements for N‐glycosylation of peptides in rat liver [PDF]

, 1979
Ernst Bause, Harald Hettkamp
openalex   +1 more source

Flux Sampling Suggests Metabolic Signatures of High Antibody‐Producing CHO Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells remain the industry standard for producing numerous therapeutic proteins, particularly monoclonal antibodies (mAbs). However, achieving higher recombinant protein titers remains an ongoing challenge and a fundamental understanding of the cellular mechanism driving improved bioprocess performance remains ...
Kate E. Meeson, Joanne Watson, Susan Rosser, Ellie Hawke, Andrew Pitt, Tessa Moses, Leon Pybus, Magnus Rattray, Alan J. Dickson, Jean‐Marc Schwartz   +9 more
wiley   +1 more source

Analysis of drug interactions with serum proteins and related binding agents by affinity capillary electrophoresis: A review

ELECTROPHORESIS, Volume 43, Issue 23-24, Page 2302-2323, December 2022., 2022
Abstract Biomolecules such as serum proteins can interact with drugs in the body and influence their pharmaceutical effects. Specific and precise methods that analyze these interactions are critical for drug development or monitoring and for diagnostic purposes.
Sadia Sharmeen, Isaac Kyei, Arden Hatch, David S. Hage   +3 more
wiley   +1 more source

ERO1 alpha deficiency impairs angiogenesis by increasing N-glycosylation of a proangiogenic VEGFA

Redox Biology, 2022
N-glycosylation and disulfide bond formation are two essential steps in protein folding that occur in the endoplasmic reticulum (ER) and reciprocally influence each other.
Ersilia Varone, Alexander Chernorudskiy, Alessandro Cherubini, Angela Cattaneo, Angela Bachi, Stefano Fumagalli, Gizem Erol, Marco Gobbi, Michael J. Lenardo, Nica Borgese, Ester Zito   +10 more
doaj  

Temporal Galactose‐Manganese Feeding in Fed‐Batch and Perfusion Bioreactors Modulates UDP‐Galactose Pools for Enhanced mAb Glycosylation Homogeneity

Biotechnology and Bioengineering, EarlyView.
This study investigates the temporal effects of galactose and manganese on the N‐glycosylation of Trastuzumab (mAb) antibody during fed‐batch and perfusion bioprocessing modes to reveal the influence of feeding schedules on mAb N‐glycosylation patterns. These findings will aid in building process control schemes for mAb bioprocessing.
Aron Gyorgypal, Erica Fratz‐Berilla, Casey Kohnhorst, David N. Powers, Shishir P. S. Chundawat   +4 more
wiley   +1 more source

AIDS and Glycosylation [PDF]

Glycobiology, 1990
Margot Larkin, Ten Feizi
openaire   +3 more sources

Biosynthesis, structure, and biological activities of envelope protein gp65 of murine coronavirus. [PDF]

, 1989
We have previously shown that gp65 (E3) is a virion structural protein which varies widely in quantity among different strains of mouse hepatitis virus (MHV). In this study, the biosynthetic pathway and possible biological activities of this protein were
La Monica, N, Lai, MM, Makino, S, Shieh, CK, Yokomori, K   +4 more
core  

Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD

Nature reviews: Gastroenterology & hepatology, 2020
M. Kudelka, S. Stowell, R. Cummings, A. Neish   +3 more
semanticscholar   +1 more source

Interference with glycosylation of glycoproteins. Inhibition of formation of lipid-linked oligosaccharides in vivo [PDF]

, 1979
R. Datema, Ralph Τ. Schwarz
openalex   +1 more source

Formation of 2-Deoxyglucose-Containing Lipid-Linked Oligosaccharides. Interference with Glycosylation of Glycoproteins [PDF]

, 1978
R. Datema, Ralph Τ. Schwarz
openalex   +1 more source