Results 41 to 50 of about 331,855 (331)

Functional divergence in the role of N-linked glycosylation in smoothened signaling [PDF]

, 2015
The G protein-coupled receptor (GPCR) Smoothened (Smo) is the requisite signal transducer of the evolutionarily conserved Hedgehog (Hh) pathway. Although aspects of Smo signaling are conserved from Drosophila to vertebrates, significant differences have ...
A Helenius, A Ruiz i Altaba, AG Soto, AG Soto, AH Polizio, AH Polizio, AJ Petrescu, AJ Zhu, AM Wilbanks, Angela M. Arensdorf, Ashley Truong, B Sivertsen, BJ Arey, BR Myers, C Torroja, C Wang, C Wang, CE Carroll, D Maier, D Nedelcu, D Rendie, D Shi, Daniel P. Stewart, David J. Robbins, DJ Casso, DJ Robbins, DM Stone, Edgar Angelats, F Landomiel, F Shen, G Navarro, Gemma Navarro, H Sasaki, J Alcedo, J Bischof, J Briscoe, J He, J Taipale, J Taipale, JD Violin, JJ Kovacs, JK Chen, JK Chen, Joseph T. Opferman, JP Incardona, KC Corbit, L Zhou, LW McGinnes, M Murone, M van den Heuvel, M Wheatley, MF Tansky, MT Barakat, N Denef, NA Riobo, Peter J. McCormick, PM Lanctot, PW Ingham, R Rana, R Rohatgi, R Rohatgi, R Schroder, R Schroder, R Teperino, R Xia, Rajat Rohatgi, RT Strachan, S Li, S Marada, S Mukhopadhyay, S Nachtergaele, S Nachtergaele, S Rajagopal, S Yao, Sigrid Nachtergaele, SK Ogden, Stacey K. Ogden, Suresh Marada, T Von Ohlen, V Marigo, X Lu, Y Nakano, Y Zhao, YH Belgacem   +83 more
core   +3 more sources

Glyco-biomarkers: Potential determinants of cellular physiology and pathology [PDF]

, 2008
Once dismissed as just the icing on the cake, sugar molecules are emerging as vital components in life’s intricate machinery. Our understanding of their function within the context of the proteins and lipids to which they are attached has matured rapidly,
Alavi, A, Axford, JS
core   +2 more sources

New insight into protein glycosylation in the development of Alzheimer’s disease

Cell Death Discovery, 2023
Alzheimer’s disease (AD) is a chronic neurodegenerative disease that seriously endangers the physical and mental health of patients, however, there are still no effective drugs or methods to cure this disease up to now.
Jingwei Zhao, Minglin Lang
doaj   +1 more source

Getting Sugar Coating Right! The Role of the Golgi Trafficking Machinery in Glycosylation

Cells, 2021
The Golgi is the central organelle of the secretory pathway and it houses the majority of the glycosylation machinery, which includes glycosylation enzymes and sugar transporters. Correct compartmentalization of the glycosylation machinery is achieved by
Zinia D’Souza, Farhana Taher Sumya, Amrita Khakurel, Vladimir Lupashin   +3 more
doaj   +1 more source

Mass Spectrometry in the Elucidation of the Glycoproteome of Bacterial Pathogens [PDF]

, 2010
Presently some three hundred post-translational modifications are known to occur in bacteria in vivo. Many of these modifications play critical roles in the regulation of proteins and control key biological processes.
Graham, Robert L. J., Hess, Sonja
core   +1 more source

Research advances of protein N-glycosylation’s biological functions and analytical methods and its role in kidney disease

Linchuang shenzangbing zazhi, 2021
As one of the most important post-translational modifications, glycosylation plays a significant role in the functions of proteins.N-glycosylation exerts critical effects in different biological processes among various forms of glycosylation, whereas ...
任伟夫, 边琪
doaj  

Quantitative Analyses Reveal Novel Roles for N-Glycosylation in a Major Enteric Bacterial Pathogen

mBio, 2019
In eukaryotes, glycosylation plays a role in proteome stability, protein quality control, and modulating protein function; however, similar studies in bacteria are lacking.
Sherif Abouelhadid, Simon J. North, Paul Hitchen, Prerna Vohra, Cosmin Chintoan-Uta, Mark Stevens, Anne Dell, Jon Cuccui, Brendan W. Wren   +8 more
doaj   +1 more source

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism [PDF]

, 2012
Cancer cells must satisfy the metabolic demands of rapid cell growth within a continually changing microenvironment. We demonstrated that the dynamic posttranslational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a key ...
Clark, Peter M., Driggers, Edward M., Goddard, William A., III, Hill, Collin, Hsieh-Wilson, Linda C., Keenan, Marie C., Mason, Daniel E., Peters, Eric C., Yi, Wen   +8 more
core   +2 more sources

Glycosylation site alteration in the evolution of influenza A (H1N1) viruses. [PDF]

PLoS ONE, 2011
Influenza virus typically alters protein glycosylation in order to escape immune pressure from hosts and hence to facilitate survival in different host environments.
Shisheng Sun, Qinzhe Wang, Fei Zhao, Wentian Chen, Zheng Li   +4 more
doaj   +1 more source

Advances in Bacterial Oligosaccharyltransferase Structure Elucidation and Potential Application to Glycoconjugate Vaccine Design

Frontiers in Bioscience-Landmark, 2023
Glycosylation is one of the most common post-translational modifications of proteins across all kingdoms of life. Diverse monosaccharides and polysaccharides can be attached to a range of amino acid residues generating N-glycosylation, O-glycosylation, C-
Riye Lu, Pengwei Li, Li Zhu, Ming Xian Chang, Songying Ouyang   +4 more
doaj   +1 more source