Results 1 to 10 of about 126,565 (168)
Nature Communications, 2022 WbbB is a structurally unusual retaining glycosyltransferase. Here, the authors show that WbbB forms an Asp232-Kdo adduct prior to transfer to the saccharide acceptor.
Taylor J. B. Forrester +9 more
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Repurposing Avasimibe to Inhibit Bacterial Glycosyltransferases
Pathogens, 2022 We are interested in identifying and characterizing small molecule inhibitors of bacterial virulence factors for their potential use as anti-virulence inhibitors.
Md Kamrul Hasan +4 more
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Current Research in Biotechnology, 2020 Glycosylated biopharmaceuticals are important in the global pharmaceutical market. Despite the importance of their glycan structures, our limited knowledge of the glycosylation machinery still hinders controllability of this critical quality attribute ...
Chenguang Liang +9 more
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Effector Glycosyltransferases in Legionella [PDF]
Frontiers in Microbiology, 2011 Legionella causes severe pneumonia in humans. The pathogen produces an array of effectors, which interfere with host cell functions. Among them are the glucosyltransferases Lgt1, Lgt2 and Lgt3 from L. pneumophila. Lgt1 and Lgt2 are produced predominately in the post-exponential phase of bacterial growth, while synthesis of Lgt3 is induced mainly in the
Belyi, Yury +2 more
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Structural Basis for the Action Mechanism of Legionella Glycosyltransferase
Small Structures, 2023 Pathogenic bacterium Legionella pneumophila, the causative agent of Legionnaires’ disease, secretes hundreds of effectors into host cells that subvert cell pathways during pathogenesis.
Tao-Tao Chen +8 more
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Microbiology Spectrum, 2022 Staphylococcus aureus (S. aureus) can cause a broad spectrum of diseases ranging from skin infections to life-threatening diseases in both community and hospital settings.
Mengyuan Xiong +8 more
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Evolution of and horizontal gene transfer in the Endornavirus genus.
PLoS ONE, 2013 The transfer of genetic information between unrelated species is referred to as horizontal gene transfer. Previous studies have demonstrated that both retroviral and non-retroviral sequences have been integrated into eukaryotic genomes.
Dami Song +4 more
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Molecules, 2020 Steroidal glycosides are important sources of innovative drugs. The increased diversification of steroidal glycosides will expand the probability of discovering active molecules.
Yan-Li Xu, Jian-Qiang Kong
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Rethinking Biosynthesis of Aclacinomycin A
Molecules, 2023 Aclacinomycin A (ACM-A) is an anthracycline antitumor agent widely used in clinical practice. The current industrial production of ACM-A relies primarily on chemical synthesis and microbial fermentation.
Ziling Xu, Pingfang Tian
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Czech Journal of Food Sciences, 2014 The properties of a previously unknown enzyme, denominated cyclodextrin glycosyltransferase, produced from Bacillus lehensis, were evaluated using affinity chromatography for protein purification.
Kate Cristina Blanco +5 more
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