Results 1 to 10 of about 136,588 (299)
A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering [PDF]
Current Research in Biotechnology, 2020 Glycosylated biopharmaceuticals are important in the global pharmaceutical market. Despite the importance of their glycan structures, our limited knowledge of the glycosylation machinery still hinders controllability of this critical quality attribute ...
Chenguang Liang +9 more
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Structural Basis for the Action Mechanism of Legionella Glycosyltransferase
Small Structures, 2023 Pathogenic bacterium Legionella pneumophila, the causative agent of Legionnaires’ disease, secretes hundreds of effectors into host cells that subvert cell pathways during pathogenesis.
Tao-Tao Chen +8 more
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Repurposing Avasimibe to Inhibit Bacterial Glycosyltransferases
Pathogens, 2022 We are interested in identifying and characterizing small molecule inhibitors of bacterial virulence factors for their potential use as anti-virulence inhibitors.
Md Kamrul Hasan +4 more
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Nature Communications, 2022 WbbB is a structurally unusual retaining glycosyltransferase. Here, the authors show that WbbB forms an Asp232-Kdo adduct prior to transfer to the saccharide acceptor.
Taylor J. B. Forrester +9 more
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Microbiology Spectrum, 2022 Staphylococcus aureus (S. aureus) can cause a broad spectrum of diseases ranging from skin infections to life-threatening diseases in both community and hospital settings.
Mengyuan Xiong +8 more
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Molecules, 2020 Steroidal glycosides are important sources of innovative drugs. The increased diversification of steroidal glycosides will expand the probability of discovering active molecules.
Yan-Li Xu, Jian-Qiang Kong
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Evolution of and horizontal gene transfer in the Endornavirus genus.
PLoS ONE, 2013 The transfer of genetic information between unrelated species is referred to as horizontal gene transfer. Previous studies have demonstrated that both retroviral and non-retroviral sequences have been integrated into eukaryotic genomes.
Dami Song +4 more
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Rethinking Biosynthesis of Aclacinomycin A
Molecules, 2023 Aclacinomycin A (ACM-A) is an anthracycline antitumor agent widely used in clinical practice. The current industrial production of ACM-A relies primarily on chemical synthesis and microbial fermentation.
Ziling Xu, Pingfang Tian
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Molecules, 2020 Isoflavones in soybeans are well-known phytoestrogens. Soy isoflavones present in conjugated forms are converted to aglycone forms during processing and storage.
Young Sung Jung +9 more
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Frontiers in Plant Science, 2020 Leaf senescence is a developmental process designed for nutrient recycling and relocation to maximize growth competence and reproductive capacity of plants.
Seulbee Lee +6 more
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