Engineering a Function into a Glycosyltransferase [PDF]
Chemistry & Biology, 2009 SummaryAs glycosyltransferases found in nature often show distinct substrate specificity, glycosyltransferase engineering is an important research field.
Krauth, Christine +9 more
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Seroprevalence and Identification of Brucella melitensis Based on a Glycosyltransferase Gene among Ruminants in Rafha, Saudi Arabia [PDF]
, 2023 Brucellosis is a zoonotic disease with veterinary, public health, and economic implications. The study aimed to estimate the seroprevalence of Brucella spp.
Hussam Hassan Arafat +2 more
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Effector Glycosyltransferases in Legionella [PDF]
Frontiers in Microbiology, 2011 Legionella causes severe pneumonia in humans. The pathogen produces an array of effectors, which interfere with host cell functions. Among them are the glucosyltransferases Lgt1, Lgt2 and Lgt3 from L. pneumophila. Lgt1 and Lgt2 are produced predominately in the post-exponential phase of bacterial growth, while synthesis of Lgt3 is induced mainly in the
Belyi, Yury +2 more
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Predicting the substrate specificity of a glycosyltransferase implicated in the production of phenolic volatiles in tomato fruit [PDF]
, 2010 The volatile compounds that constitute the fruit aroma of ripe tomato (Solanum lycopersicum) are often sequestered in glycosylated form. A homology-based screen was used to identify the gene SlUGT5, which is a member of UDP-glycosyltransferase 72 family ...
Chervin, Christian +15 more
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The retaining Pse5Ac7Ac pseudaminyltransferase KpsS1 defines a new glycosyltransferase family (GTXXX) [PDF]
, 2023 Cell surface sugar 5,7-diacetyl pseudaminic acid (Pse5Ac7Ac) is a bacterial analogue of the ubiquitous sialic acid, Neu5Ac, and contributes to the virulence of a number of multidrug resistant bacteria, including ESKAPE pathogens Pseudomonas aeruginosa ...
Natasha, Hatton +8 more
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Enzymatic activity of glycosyltransferase GLT8D1 promotes human glioblastoma cell migration. [PDF]
, 2022 peer reviewedGlioblastoma (GBM) is the most aggressive primary brain tumor characterized by infiltrative growth of malignant glioma cells into the surrounding brain parenchyma.
GERLOFF, Dietlind +17 more
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Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei [PDF]
, 2014 Trypanosoma brucei expresses a diverse repertoire of N-glycans, ranging from oligomannose and paucimannose structures to exceptionally large complex N-glycans.
Damerow, Manuela +5 more
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Structural Characterization and Ligand-Induced Conformational Changes of SenB, a Se-Glycosyltransferase Involved in Selenoneine Biosynthesis [PDF]
, 2023 Selenium (Se) is an essential micronutrient that is found naturally in proteins, nucleic acids, and natural products. Unlike selenoproteins and selenonucleic acids, little is known about the structures of the biosynthetic enzymes that incorporate Se into
Jonathan, Huang +4 more
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Mechanistic evidence for a front-side, SNi-type reaction in a retaining glycosyltransferase [PDF]
, 2011 A previously determined crystal structure of the ternary complex of trehalose-6-phosphate synthase identified a putative transition state–like arrangement based on validoxylamine A 6?-O-phosphate and uridine diphosphate in the active site.
Errey, James C. +18 more
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TbGT8 is a bifunctional glycosyltransferase that elaborates N-linked glycans on a protein phosphatase AcP115 and a GPI-anchor modifying glycan in Trypanosoma brucei [PDF]
, 2014 The procyclic form of Trypanosoma brucei expresses procyclin surface glycoproteins with unusual glycosylphosphatidylinositol-anchor side chain structures that contain branched N-acetyllactosamine and lacto-N-biose units.
Hashida, Kazunori +7 more
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