Results 71 to 80 of about 136,588 (299)

Rational Design of an Aryl-C-Glycoside Catalyst from a Natural Product O-Glycosyltransferase [PDF]

, 2011
SummaryBecause the sugar moieties of natural products are primarily O-linked, the hydrolytic sensitivity of the glycosidic linkage limits their therapeutic application.
Benjamin Lauinger, Lauinger, Benjamin, Andriy Luzhetskyy, Andreas Bechthold, Weber, Monika, Johannes Härle, Bernd Kammerer, Stefan Günther, Zechel, David L., Härle, Johannes, Kammerer, Bernd, Luzhetskyy, Andriy, Monika Weber, David L. Zechel, Günther, Stefan, Bechthold, Andreas   +15 more
core   +1 more source

Design of glycosyltransferase inhibitors : serine analogues as pyrophosphate surrogates ?

, 2015
International audienceMimicking the diphosphate moiety of nucleotide diphosphate sugars with serine analogues provided modest glycosyltransferase inhibitors.
Shuai Wang, Sébastien Vidal, Striebeck, Alexander, Lafont, Dominique, Dominique Lafont, Jose A. Cuesta‐Seijo, Vidal, Sébastien, Alexander Striebeck, Monica M. Palcic, Wang, Shuai, Cuesta-Seijo, José A., Palcic, Monica M.   +11 more
core   +1 more source

A New Helical Binding Domain Mediates a Glycosyltransferase Activity of a Bifunctional Protein [PDF]

, 2016
Serine-rich repeat glycoproteins (SRRPs) conserved in streptococci and staphylococci are important for bacterial colonization and pathogenesis. Fap1, a well studied SRRP is a major surface constituent of Streptococcus parasanguinis and is required for ...
Yang, T, Haslam, SM, Dell, A, Wu, H, Zhang, H, Zhou, M   +5 more
core   +1 more source

Baikalomycins A-C, New Aquayamycin-Type Angucyclines Isolated from Lake Baikal Derived Streptomyces sp. IB201691-2A

Microorganisms, 2020
Natural products produced by bacteria found in unusual and poorly studied ecosystems, such as Lake Baikal, represent a promising source of new valuable drug leads. Here we report the isolation of a new Streptomyces sp.
Irina Voitsekhovskaia, Constanze Paulus, Charlotte Dahlem, Yuriy Rebets, Suvd Nadmid, Josef Zapp, Denis Axenov-Gribanov, Christian Rückert, Maxim Timofeyev, Jörn Kalinowski, Alexandra K. Kiemer, Andriy Luzhetskyy   +11 more
doaj   +1 more source

Notch signaling: Fringe really is a glycosyltransferase [PDF]

, 2000
Fringe modifies the ligand-selectivity of Notch in ways that are crucial for a number of Notch’s developmental functions. Recent results have confirmed the suspicion that Fringe is a glycosyltransferase that works in the Golgi complex by modifying Notch ...
Blair, Seth S.
core   +1 more source

Overexpression of Brucella putative glycosyltransferase WbkA in B. abortus RB51 leads to production of exopolysaccharide

Frontiers in Cellular and Infection Microbiology, 2015
Brucella spp. are Gram-negative, facultative intracellular bacteria that cause brucellosis in mammals. Brucella strains containing the O-polysaccharide in their cell wall structure exhibit a smooth phenotype whereas the strains devoid of the ...
Neha eDabral, Neeta eJain-Gupta, Mohamed Naguieb Seleem, Nammalwar eSriranganathan, Ramesh eVemulapalli   +4 more
doaj   +1 more source

Tracking down biotransformation to the genetic level: identification of a highly flexible glycosyltransferase from Saccharothrix espanaensis. [PDF]

, 2013
Saccharothrix espanaensis is a member of the order Actinomycetales. The genome of the strain has been sequenced recently, revealing 106 glycosyltransferase genes.
Stasevych, Maryna, Stanko, Oleg, Brötz, Elke, Luzhetskyy, Andriy N, Luzhetska, Marta, Linnenbrink, Anton, Luzhetskyy, Andriy, Strobel, Tina, Paululat, Thomas, Schmidt, Yvonne, Novikov, Volodymyr, Taguchi, Takaaki, Bechthold, Andreas   +12 more
core   +1 more source

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source

Comprehensive analysis of the triterpenoid saponins biosynthetic pathway in Anemone flaccida by transcriptome and proteome profiling

Frontiers in Plant Science, 2016
In this study, we conducted the tandem transcriptome and proteome profiling of a non-model medicinal plant, A. flaccida. Using Illumina HiSeq 2000 sequencing platform and iTRAQ technique, a total of 46,962 high-quality unigenes were obtained with an ...
Xuebo Hu
doaj   +1 more source

The C. elegans glycosyltransferase BUS-8 has two distinct and essential roles in epidermal morphogenesis.

, 2008
Ventral enclosure in Caenorhabditis elegans involves migration of epidermal cells over a neuroblast substrate and subsequent adhesion at the ventral midline.
Gravato-Nobre, M.J., Hodgkin, J., Partridge, F.A., Schafer, W.R., Tearle, A.W.   +4 more
core   +1 more source