Results 51 to 60 of about 22,975 (220)

Protein O-Fucosyltransferase 1 Undergoes Interdomain Flexibility in Solution

Molecules, 2021
Protein O-fucosyltransferase 1 (PoFUT1) is a GT-B fold enzyme that fucosylates proteins containing EGF-like repeats. GT-B glycosyltransferases have shown a remarkable grade of plasticity adopting closed and open conformations as a way of tuning their ...
Erandi Lira-Navarrete, María Carmen Pallarés, Fabio Castello, Maria J. Ruedas-Rama, Angel Orte, Anabel Lostao, Ramón Hurtado-Guerrero   +6 more
doaj   +1 more source

Cell wall modulation by drought and elevated CO2 in sugarcane leaves

Frontiers in Plant Science
Climate change poses significant challenges to global agriculture, with elevated atmospheric CO2 (eCO2) concentrations and increased frequency of droughts affecting crop productivity.
Alexandre Junio Borges Araujo, Amanda Pereira de Souza, Débora Pagliuso, Mauro de Medeiros Oliveira, Bruno Viana Navarro, Adriana Grandis, Marcos Silveira Buckeridge   +6 more
doaj   +1 more source

Enzymatic Cascades for Tailored ¹³C₆ and ¹⁵N Enriched Human Milk Oligosaccharides

Molecules, 2019
Several health benefits, associated with human milk oligosaccharides (HMOS), have been revealed in the last decades. Further progress, however, requires not only the establishment of a simple “routine” method for absolute quantification of ...
Thomas Fischöder, Samanta Cajic, Valerian Grote, Raphael Heinzler, Udo Reichl, Matthias Franzreb, Erdmann Rapp, Lothar Elling   +7 more
doaj   +1 more source

Glycobiology of the Epithelial to Mesenchymal Transition

Biomedicines, 2021
Glycosylation consists in the covalent, enzyme mediated, attachment of sugar chains to proteins and lipids. A large proportion of membrane and secreted proteins are indeed glycoproteins, while glycolipids are fundamental component of cell membranes.
Michela Pucci, Nadia Malagolini, Fabio Dall’Olio   +2 more
doaj   +1 more source

Progress on Synthetic Biology for Steviol Glycosides Biosynthesis

Shipin gongye ke-ji
Stevioside, also known as stevia, is a class of diterpenoids extracted from stevia with high sweetness, low calories, safety and non-toxicity, hypoglycemic, hypotensive, and other physiological characteristics.
Mengyu LIU, Hailin HE, Ting MA, Xiaochun SU, Yifei DING, Jinxuan WANG, Yinfeng LEI, Shubo LI   +7 more
doaj   +1 more source

Engineering a Function into a Glycosyltransferase

Chemistry & Biology, 2009
As glycosyltransferases found in nature often show distinct substrate specificity, glycosyltransferase engineering is an important research field. In this work, we were able to introduce an activity into a glycosyltransferase involved in natural product (landomycin E) biosynthesis.
Krauth, Christine, Fedoryshyn, Marta, Schleberger, Christian, Luzhetskyy, Andriy, Bechthold, Andreas   +4 more
openaire   +3 more sources

Deciphering glycosylation-driven prognostic insights and therapeutic prospects in glioblastoma through a comprehensive regulatory model

Frontiers in Oncology
The oncogenesis and development of glioblastoma multiforme have been linked to glycosylation modifications, which are common post-translational protein modifications.
Xingyi Jin, Zhuo Chen, Hang Zhao
doaj   +1 more source

High Expression of the Sd^a Synthase B4GALNT2 Associates with Good Prognosis and Attenuates Stemness in Colon Cancer

Cells, 2020
Background: The carbohydrate antigen Sda and its biosynthetic enzyme B4GALNT2 are highly expressed in normal colonic mucosa but are down-regulated to a variable degree in colon cancer tissues.
Michela Pucci, Inês Gomes Ferreira, Martina Orlandani, Nadia Malagolini, Manuela Ferracin, Fabio Dall’Olio   +5 more
doaj   +1 more source

Ganglioside biosynthesis. Characterization of uridine diphosphate galactose: GM2 galactosyltransferase in Golgiapparatus from rat liver

Journal of Lipid Research, 1976
An enzyme that transfers galactose from UDP-Gal to ganglioside GM2 (Tay-Sachs ganglioside) was concentrated 50 times in Golgi apparatus from rat liver relative to total homogenates.
F E Wilkinson, D J Morré, T W Keenan
doaj   +1 more source

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source