Results 61 to 70 of about 26,147 (300)

N-glycomic Complexity in Anatomical Simplicity: Caenorhabditis elegans as a Non-model Nematode?

Frontiers in Molecular Biosciences, 2019
Caenorhabditis elegans is a genetically well-studied model nematode or “worm”; however, its N-glycomic complexity is actually baffling and still not completely unraveled. Some features of its N-glycans are, to date, unique and include bisecting galactose
Katharina Paschinger, Shi Yan, Iain B. H. Wilson   +2 more
doaj   +1 more source

Protein O-Fucosyltransferase 1 Undergoes Interdomain Flexibility in Solution

Molecules, 2021
Protein O-fucosyltransferase 1 (PoFUT1) is a GT-B fold enzyme that fucosylates proteins containing EGF-like repeats. GT-B glycosyltransferases have shown a remarkable grade of plasticity adopting closed and open conformations as a way of tuning their ...
Erandi Lira-Navarrete, María Carmen Pallarés, Fabio Castello, Maria J. Ruedas-Rama, Angel Orte, Anabel Lostao, Ramón Hurtado-Guerrero   +6 more
doaj   +1 more source

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

Enzymatic Cascades for Tailored ¹³C₆ and ¹⁵N Enriched Human Milk Oligosaccharides

Molecules, 2019
Several health benefits, associated with human milk oligosaccharides (HMOS), have been revealed in the last decades. Further progress, however, requires not only the establishment of a simple “routine” method for absolute quantification of ...
Thomas Fischöder, Samanta Cajic, Valerian Grote, Raphael Heinzler, Udo Reichl, Matthias Franzreb, Erdmann Rapp, Lothar Elling   +7 more
doaj   +1 more source

Glycobiology of the Epithelial to Mesenchymal Transition

Biomedicines, 2021
Glycosylation consists in the covalent, enzyme mediated, attachment of sugar chains to proteins and lipids. A large proportion of membrane and secreted proteins are indeed glycoproteins, while glycolipids are fundamental component of cell membranes.
Michela Pucci, Nadia Malagolini, Fabio Dall’Olio   +2 more
doaj   +1 more source

Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development

, 2013
Background: Chondroitin/dermatan sulfate (CS/DS) proteoglycans present in the extracellular matrix have important structural and regulatory functions. Results: Six human genes have previously been shown to catalyze CS/DS polymerization. Here we show that
Inger Eriksson, Haitina, Tatjana,, Lena Kjellén, Filipek-Gorniok, Beata,, Ledin, Johan,, Eriksson, Inger,, Tatjana Haitina, Marta Bastos Oliveira, Holmborn, Katarina,, Charlotte Hellgren, Oliveira, Marta Bastos,, Judith Habicher, Habicher, Judith,, Katarina Holmborn, Johan Ledin, Beata Filipek‐Górniok, Hellgren, Charlotte,, Kreuger, Johan,, Johan Kreuger, Kjellén, Lena,   +19 more
core   +1 more source

Structures and mechanisms of glycosyltransferases [PDF]

Glycobiology, 2005
Glycosyltransferases (GTs) catalyze the transfer of a sugar moiety from an activated donor sugar onto saccharide and nonsaccharide acceptors. A sequence-based classification spreads GTs in many families thus reflecting the variety of molecules that can be used as acceptors.
Breton, C., Snajdrova, L., Jeanneau, C., Koca, J., Imberty, A.   +4 more
openaire   +2 more sources

35 Individuals With HUWE1‐Related Neurodevelopmental Disorder and Suggested Clinical Evaluations

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT HUWE1 (HECT, UBA, and WWE Domain Containing E3 Ubiquitin Protein Ligase1, OMIM 300697), located at Xp11.22, encodes a ubiquitin ligase that is highly conserved across species. Genetic variants in HUWE1 described in multiple independent studies cause X‐linked intellectual disability, including in the patients identified by Juberg, Marsidi, and ...
Mindy H. Li, Deziree L. Coleman, Kelsey Hogan, Danielle Luz, Lindsay Bhandari, Newell Belnap, Tiffany Busa, Charles Coutton, Klaus Dieterich, Svetlana Gorokhova, Clara Hildebrandt, Rachel Logan, Milena Mariani, Manuela Morleo, Vincenzo Nigro, John Pappas, Rachel Rabin, Kelly Schoch, Angelo Selicorni, Vandana Shashi, Rebecca Spillmann, Jennifer Sullivan, Charlotte Tardy, Samantha A. Schrier Vergano, Brock Grill, Kristin Baranano   +25 more
wiley   +1 more source

Cell wall modulation by drought and elevated CO2 in sugarcane leaves

Frontiers in Plant Science
Climate change poses significant challenges to global agriculture, with elevated atmospheric CO2 (eCO2) concentrations and increased frequency of droughts affecting crop productivity.
Alexandre Junio Borges Araujo, Amanda Pereira de Souza, Débora Pagliuso, Mauro de Medeiros Oliveira, Bruno Viana Navarro, Adriana Grandis, Marcos Silveira Buckeridge   +6 more
doaj   +1 more source

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source