Results 21 to 30 of about 1,170 (199)
Mass Spectrometry Reviews, Volume 42, Issue 5, Page 1984-2206, September/October 2023., 2023 Abstract This review is the tenth update of the original article published in 1999 on the application of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2020.
David J. Harvey
wiley +1 more source
Comprehensive Reviews in Food Science and Food Safety, Volume 22, Issue 4, Page 2611-2651, July 2023., 2023 Abstract Prebiotics have long been used to modulate the gut microbiota and improve host health. Most established prebiotics are nondigestible carbohydrates, especially short‐chain oligosaccharides. Recently, gluco‐oligosaccharides (GlcOS) with 2–10 glucose residues and one or more O‐glycosidic linkage(s) have been found to exert prebiotic potentials ...
Meijun Zeng +2 more
wiley +1 more source
Hijacking the Peptidoglycan Recycling Pathway of Escherichia coli to Produce Muropeptides
Chemistry – A European Journal, Volume 29, Issue 6, January 27, 2023., 2023 A straightforward access to Gram‐negative and Gram‐positive muropeptides was developed by a chemo‐enzymatic strategy based on metabolically engineered E.coli cells. Abstract Soluble fragments of peptidoglycan called muropeptides are released from the cell wall of bacteria as part of their metabolism or as a result of biological stresses.
Antoine Rousseau +6 more
wiley +1 more source
Biotechnology and Bioengineering, Volume 119, Issue 6, Page 1343-1358, June 2022., 2022 Upstream and downstream processing strategies to control antibody glycosylation are reviewed. Edwards et al. have presented various approaches in both upstream and downstream processing to direct antibody glycosylation towards certain profiles.
Elizabeth Edwards +6 more
wiley +1 more source
Enzymatic Late‐Stage Modifications: Better Late Than Never
Angewandte Chemie International Edition, Volume 60, Issue 31, Page 16824-16855, July 26, 2021., 2021 Late‐stage modification is an indispensable approach for compound diversification in synthesis. Since enzymes offer particularly powerful means for mild, catalyst‐controlled functionalisations, in recent years several novel biocatalytic methods have emerged enabling a broad array of orthogonal reactions.
Elvira Romero +7 more
wiley +1 more source
Biocatalysis: Enzymatic Synthesis for Industrial Applications
Angewandte Chemie International Edition, Volume 60, Issue 1, Page 88-119, January 4, 2021., 2021 Biocatalysis has developed into a mature technology for chemical and pharmaceutical synthesis as well as other areas where high selectivity and mild reaction conditions are required. This Review highlights recent achievements with a special focus on industrialized applications including the introduction of key performance indicators (KPIs) to judge the
Shuke Wu +4 more
wiley +1 more source
Enzymatic Building‐Block Synthesis for Solid‐Phase Automated Glycan Assembly
Angewandte Chemie, Volume 132, Issue 50, Page 22642-22645, December 7, 2020., 2020 In a chemoenzymatic approach to oligosaccharide synthesis, the scalability potential of enzymatic synthesis was exploited for the preparative synthesis of a relevant N‐acetyllactosamine disaccharide building block. This disaccharide was then applied successfully to the automated synthesis of a target oligosaccharide using the glycan synthesizer ...
Andrea Marchesi +7 more
wiley +2 more sources
Design and applications of bifunctional small molecules: Why two heads are better than one [PDF]
, 2008 Induction of protein−protein interactions is a daunting challenge, but recent studies show promise for small molecules that specifically bring two or more protein molecules together for enhanced or novel biological effect.
Aberle, Nicholas +2 more
core +1 more source
Catalytic Promiscuity of Transaminases : Preparation of Enantioenriched β-Fluoroamines by Formal Tandem Hydrodefluorination/Deamination [PDF]
, 2016 Transaminases are valuable enzymes for industrial biocatalysis and enable the preparation of optically pure amines. For these transformations they require either an amine donor (amination of ketones) or an amine acceptor (deamination of racemic amines ...
Ahrens +47 more
core +3 more sources
Conversion of a cyclodextrin glucanotransferase into an alpha-amylase:Assessment of directed evolution strategies [PDF]
, 2007 Glycoside hydrolase family 13 (GH13) members have evolved to possess various distinct reaction specificities despite the overall structural similarity.
Dijkhuizen, Lubbert +2 more
core +2 more sources