Results 21 to 30 of about 602 (161)
Comprehensive Reviews in Food Science and Food Safety, Volume 22, Issue 4, Page 2611-2651, July 2023., 2023 Abstract Prebiotics have long been used to modulate the gut microbiota and improve host health. Most established prebiotics are nondigestible carbohydrates, especially short‐chain oligosaccharides. Recently, gluco‐oligosaccharides (GlcOS) with 2–10 glucose residues and one or more O‐glycosidic linkage(s) have been found to exert prebiotic potentials ...
Meijun Zeng +2 more
wiley +1 more source
Chemo‐Enzymatic Synthesis of Long‐Chain Oligosaccharides for Studying Xylan‐Modifying Enzymes
Chemistry – A European Journal, Volume 29, Issue 26, May 8, 2023., 2023 Xylan biosynthesis: Starting from dixylosides, chemo‐enzymatic syntheses of xylan dodecasaccharides using glycosynthase‐mediated coupling reactions between glycosyl fluoride donors and thioglycoside acceptors were performed. These long‐chain xylan oligosaccharides were incubated with xylan‐modifying enzymes from plants, i.
Ignacio Álvarez‐Martínez +5 more
wiley +1 more source
Hijacking the Peptidoglycan Recycling Pathway of Escherichia coli to Produce Muropeptides
Chemistry – A European Journal, Volume 29, Issue 6, January 27, 2023., 2023 A straightforward access to Gram‐negative and Gram‐positive muropeptides was developed by a chemo‐enzymatic strategy based on metabolically engineered E.coli cells. Abstract Soluble fragments of peptidoglycan called muropeptides are released from the cell wall of bacteria as part of their metabolism or as a result of biological stresses.
Antoine Rousseau +6 more
wiley +1 more source
Biotechnology and Bioengineering, Volume 119, Issue 6, Page 1343-1358, June 2022., 2022 Upstream and downstream processing strategies to control antibody glycosylation are reviewed. Edwards et al. have presented various approaches in both upstream and downstream processing to direct antibody glycosylation towards certain profiles.
Elizabeth Edwards +6 more
wiley +1 more source
Enzymatic Late‐Stage Modifications: Better Late Than Never
Angewandte Chemie International Edition, Volume 60, Issue 31, Page 16824-16855, July 26, 2021., 2021 Late‐stage modification is an indispensable approach for compound diversification in synthesis. Since enzymes offer particularly powerful means for mild, catalyst‐controlled functionalisations, in recent years several novel biocatalytic methods have emerged enabling a broad array of orthogonal reactions.
Elvira Romero +7 more
wiley +1 more source
Biocatalysis: Enzymatic Synthesis for Industrial Applications
Angewandte Chemie International Edition, Volume 60, Issue 1, Page 88-119, January 4, 2021., 2021 Biocatalysis has developed into a mature technology for chemical and pharmaceutical synthesis as well as other areas where high selectivity and mild reaction conditions are required. This Review highlights recent achievements with a special focus on industrialized applications including the introduction of key performance indicators (KPIs) to judge the
Shuke Wu +4 more
wiley +1 more source
Enzymatic Building‐Block Synthesis for Solid‐Phase Automated Glycan Assembly
Angewandte Chemie, Volume 132, Issue 50, Page 22642-22645, December 7, 2020., 2020 In a chemoenzymatic approach to oligosaccharide synthesis, the scalability potential of enzymatic synthesis was exploited for the preparative synthesis of a relevant N‐acetyllactosamine disaccharide building block. This disaccharide was then applied successfully to the automated synthesis of a target oligosaccharide using the glycan synthesizer ...
Andrea Marchesi +7 more
wiley +2 more sources
Glycosidases in Carbohydrate Synthesis: When Organic Chemistry Falls Short
CHIMIA, 2011 Thanks to the stability, good availability, stereoselectivity and broad substrate specificity, oligosaccharide synthesis catalyzed by glycosidases represents an elegant way to complex carbohydrate structures.
Pavla Bojarová, Vladimír Kren
doaj +1 more source
, 2021 Engineering of carbohydrate-active enzymes such as glycosynthases to enable chemoenzymatic synthesis of bespoke oligosaccharides has been limited by the lack of suitable ultrahigh-throughput screening methods capable of robustly detecting either starting
Ayushi Agrawal +11 more
core +1 more source
Reagent Engineering for Group Transfer Biocatalysis
Angewandte Chemie, Volume 136, Issue 7, February 12, 2024.Biocatalytic group transfer reactions can efficiently generate highly complex molecules under mild and environmentally friendly conditions. This Minireview highlights inspiring examples of the development of non‐natural donor reagents to power such enzymatic transformations, while discussing the design aspects behind the choice of reagent.
John H. Reed, Florian P. Seebeck
wiley +2 more sources