Results 31 to 40 of about 5,898,960 (197)

The therapeutic effect of glycyrrhizic acid compound ointment on imiquimod-induced psoriasis-like disease in mice.

PLoS ONE, 2023
Glycyrrhetinic acid, a drug with anti-inflammatory effects, enhanced the activity of antipsoriatic efficacy. In this research, an ointment with glycyrrhetinic acid was prepaired as the major component and several other herbal monomers (astilbin, osthole,
Yanwen Zhang, Qian Wang, Shuangyong Sun, Lingyan Jiang   +3 more
doaj   +1 more source

Glycyrrhetinic acid regulates impaired macrophage autophagic flux in the treatment of non-alcoholic fatty liver disease

Frontiers in Immunology, 2022
Macrophages are involved in hepatocyte steatosis and necroinflammation and play an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Impaired autophagy function (decreased autophagy or blocked autophagic flow) leads to cell
Yadong Fan, Wenjing Dong, Ying Wang, Shan-Ji Zhu, R. Chai, Zhe Xu, Xiaoyu Zhang, Yiqi Yan, Long Yang, Yuhong Bian   +9 more
semanticscholar   +1 more source

Analysis of the network pharmacology and the structure-activity relationship of glycyrrhizic acid and glycyrrhetinic acid

Frontiers in Pharmacology, 2022
Licorice, a herbal product derived from the root of Glycyrrhiza species, has been used as a sweetening agent and traditional herbal medicine for hundreds of years.
Qingqiang Ni, Yuxuan Gao, Xiuzhen Yang, Qing-meng Zhang, Baojian Guo, Jinxiang Han, Shaoru Chen   +6 more
semanticscholar   +1 more source

Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2

iScience, 2022
Summary Glycyrrhetinic acid (GA) is a natural product of licorice with mitochondria targeting properties and shows broad anticancer activities, but its targets and underlying mechanisms remain elusive.
Xiuxiu Jin, Li Li, Qin Peng, Chunmei Gan, Li Gao, Siyu He, Shuangyan Tan, Wenchen Pu, Yu Liu, Yanqiu Gong, Yuqin Yao, G. Wang, Xiaohui Liu, Meng Gong, Peng Lei, Huiyuan Zhang, Shiqian Qi, Heng Xu, Hongbo Hu, Biao Dong, Yong Peng, Dan Su, Lunzhi Dai   +22 more
semanticscholar   +1 more source

Development of Glycyrrhetinic Acid and Folate Modified Cantharidin Loaded Solid Lipid Nanoparticles for Targeting Hepatocellular Carcinoma

Molecules, 2022
Cantharidin (CTD) is the major component of anticancer drugs obtained from Mylabris Cichorii and has a good inhibitory effect on several cancers, including hepatocellular carcinoma (HCC) and breast cancer.
Yiling Xu, Min Wang, Shuangcheng Ning, Zhong Yang, Lili Zhou, Xinhua Xia   +5 more
semanticscholar   +1 more source

Anti-inflammatory and Pro-apoptotic Effects of 18beta-Glycyrrhetinic Acid In Vitro and In Vivo Models of Rheumatoid Arthritis

Frontiers in Pharmacology, 2021
18β-Glycyrrhetinic acid (18β-GA), an active component from Glycyrrhiza glabra L. root (licorice), has been demonstrated to be able to protect against inflammatory response and reduce methotrexate (MTX)-derived toxicity.
Yunhui Feng, Liyan Mei, Maojie Wang, Qingchun Huang, Runyue Huang   +4 more
semanticscholar   +1 more source

18β-Glycyrrhetinic acid suppresses allergic airway inflammation through NF-κB and Nrf2/HO-1 signaling pathways in asthma mice

Scientific Reports, 2021
18β-Glycyrrhetinic acid (18β-GA), the main bioactive component of Glycyrrhizae Radix, is considered a promising anti-inflammatory and antioxidant agent.
Jianming Liu, Yanqi Xu, Minyu Yan, Yin-Juan Yu, Yongmei Guo   +4 more
semanticscholar   +1 more source

Identification of potential anti-pneumonia pharmacological components of Glycyrrhizae Radix et Rhizoma after the treatment with Gan An He Ji oral liquid

Journal of Pharmaceutical Analysis, 2022
Glycyrrhizae Radix et Rhizoma, a traditional Chinese medicine also known as Gan Cao (GC), is frequently included in clinical prescriptions for the treatment of pneumonia.
Xiaojuan Jiang, Yihua Lin, Yunlong Wu, Caixia Yuan, Xuli Lang, Jiayun Chen, Chunyan Zhu, Xinyi Yang, Yu Huang, Hao Wang, Caisheng Wu   +10 more
doaj   +1 more source

Synthesis of glycyrrhetinic acid-modified liposomes to deliver Murrayafoline A for treatment of hepatocellular carcinoma

Journal of Materials Science: Materials in Medicine, 2022
Hepatocellular carcinoma is a common type of cancer associated with a high mortality rate. Among several bioactive compounds, Murrayafoline A (MuA) has been proved as a bio substance that exhibits great potentials in treating liver cancer.
C. T. Dinh, H. Vu, Q. H. T. Phan, L. Nguyen, Toan Quoc Tran, D. Van Tran, N. N. Quy, D. Pham, D. Nguyen   +8 more
semanticscholar   +1 more source

Evidence for Anti-Inflammatory Activity of Isoliquiritigenin, 18β Glycyrrhetinic Acid, Ursolic Acid, and the Traditional Chinese Medicine Plants Glycyrrhiza glabra and Eriobotrya japonica, at the Molecular Level

Medicines, 2019
Background: We investigated the effect of root extracts from the traditional Chinese medicine (TCM) plants Glycyrrhiza glabra L., Paeonia lactiflora Pall., and the leaf extract of Eriobotrya japonica (Thunb.) Lindl., and their six major secondary ...
Jun-Xian Zhou, Michael Wink
doaj   +1 more source