Results 41 to 50 of about 5,898,960 (197)
Glycyrrhetinic acid: a promising scaffold for the discovery of anticancer agents
Expert Opinion on Drug Discovery, 2021 Introduction Oleanane-type pentacyclic triterpenes named glycyrrhetinic acids (GAs) featuring a C-30 carboxylic acid group, are extracted from the licorice (Glycyrrhiza uralensis).
H. Hussain +10 more
semanticscholar +1 more source
Synthesis and Antiproliferative Activity of Novel A-Ring Cleaved Glycyrrhetinic Acid Derivatives
Molecules, 2019 A series of new glycyrrhetinic acid derivatives was synthesized via the opening of its ring A along with the coupling of an amino acid. The antiproliferative activity of the derivatives was evaluated against a panel of nine human cancer cell lines ...
Daniela P.S. Alho +3 more
doaj +1 more source
Advanced Science, EarlyView.This review elucidates URB design strategies, including genetic and physicochemical modifications, while dissecting the synergistic mechanisms governing spatiotemporal control. It further evaluates applications in targeted drug delivery, gene modulation, and immunotherapy, finally offering perspectives on overcoming translational barriers for clinical ...
Xueyao Wang +5 more
wiley +1 more source
The Scientific World Journal, 2013 The triblock 18β-glycyrrhetinic acid-poly(ethylene glycol)-18β-glycyrrhetinic acid conjugates (GA-PEG-GA) based self-assembled micelles were synthesized and characterized by FTIR, NMR, transmission electron microscopy, and particle size analysis.
Fengbo Wu +6 more
doaj +1 more source
Cell Death and Disease, 2021 Acute liver injury (ALI) has multiple causes and results in liver dysfunction. Severe or persistent liver injury eventually leads to liver failure and even death.
Shouyan Wu +8 more
semanticscholar +1 more source
ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.This study investigates Spanish broom (Spartium junceum) as a renewable source for electrospun composite membranes in sustainable water purification. MCC and biochar were functionalized with eco‐friendly precursors and nanomaterials (i.e., HNT, β‐CDs) to develop hybrid PVA nanofiber composites.
Giulia Rando +7 more
wiley +1 more source
Interdisciplinary Medicine, EarlyView.Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi +6 more
wiley +1 more source
Molecules, 2021 Glycyrrhetinic acid (GA) is one of many interesting pentacyclic triterpenoids showing significant anticancer activity by triggering apoptosis in tumor cell lines.
G. Moustafa +6 more
semanticscholar +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.Reusing organic waste materials, such as animal manure, as soil amendments reduces water and fertiliser demand, contributing to achieving the Sustainable Development Goals. However, organic wastes may contain contaminants of emerging concern (CECs), posing potential ecosystem and human health risks. Despite the importance of this issue, there is a lack
Felicity C. T. Elder +7 more
wiley +1 more source
Journal of Pharmacological Sciences, 2014 .: Septic shock and associated vascular hyporeactivity to vasoconstrictor agonists remain a major problem of critical care medicine. Here we report that glycyrrhetinic acid (GA), the active component of licorice, effectively restores vascular ...
Bernard Muller +3 more
doaj +1 more source