Glycyrrhizin as a potential disease-modifying therapy for epilepsy: insights into targeting pyroptosis to exert neuroprotective and anticonvulsant effects [PDF]
Frontiers in PharmacologyBackgroundFor patients with epilepsy, antiseizure medication remains the primary treatment; however, it is ineffective in approximately 30% of cases. These patients experience progressive neuronal damage and poor outcomes.
Lei Wei +6 more
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Glycyrrhizin's Potential to Modulate Feeding Behaviour by Neutralizing Reduced Feed Intake in Inflamed Arian Broilers [PDF]
Veterinary Medicine and ScienceBackground The Arian broiler, an important native Iranian breed, shows heightened sensitivity to metabolic disturbances caused by lipopolysaccharide (LPS). This study evaluated whether glycyrrhizin could mitigate LPS‐associated physiological disruptions.
Mitra Nowrouzpour +2 more
doaj +3 more sources
Glycyrrhizin Effectively Inhibits SARS-CoV-2 Replication by Inhibiting the Viral Main Protease
Viruses, 2021 The outbreak of SARS-CoV-2 developed into a global pandemic affecting millions of people worldwide. Despite one year of intensive research, the current treatment options for SARS-CoV-2 infected people are still limited. Clearly, novel antiviral compounds
Lukas van de Sand +2 more
exaly +4 more sources
The potential of glycyrrhizin and licorice extract in combating COVID-19 and associated conditions
Phytomedicine Plus, 2021 Background: Several recent studies have stated that glycyrrhizin and licorice extract are present in most traditional Chinese medicine formulas used against SARS-CoV-2 in China.
Adel A Gomaa
exaly +4 more sources
Protective effect of glycyrrhizin, a direct HMGB1 inhibitor, on post-contrast acute kidney injury [PDF]
Scientific Reports, 2021 Post contrast-acute kidney injury (PC-AKI) is defined as the deterioration of renal function after administration of iodinated contrast media. HMGB1 is known to play an important role in the development of acute kidney injury.
Hyewon Oh +5 more
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Glycyrrhizin alleviates contrast-induced acute kidney injury via inhibiting HMGB1-mediated renal tubular epithelial cells ferroptosis [PDF]
Renal FailureContrast-induced acute kidney injury (CI-AKI) is the third leading cause of AKI, but there are no effective preventive or therapeutic measures in clinical practice. Glycyrrhizin, a bioactive compound isolated from the Glycyrrhiza glabra L., exhibits anti-
Fang-yuan Tian +9 more
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Exogenous ethanol treatment promotes glycyrrhizin accumulation in aseptically grown Glycyrrhiza uralensis seedlings [PDF]
Plant Signaling & BehaviorLicorice, the dried roots and rhizomes of Glycyrrhiza uralensis Fisch., is one of the most popular herbal medicines used globally. Glycyrrhizin is the primary bioactive component of licorice, exhibiting various pharmacological activities. Herein, we grew
Yuto Nishidono, Ken Tanaka
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Investigating the efficacy of dipotassium glycyrrhizin emollients in adult atopic dermatitis: A focused randomized parallel-controlled clinical study. [PDF]
Pak J Med SciXia J, Liu X, Wang Z, Zhang Y, Jiang G.
europepmc +2 more sources
Dietary glycyrrhizin enhances reproductive performance by improving intestinal microbiota, liver lipid metabolism and ovarian senescence in aged breeder hens. [PDF]
J Anim Sci BiotechnolHuang Z +7 more
europepmc +3 more sources
Compound Glycyrrhizin Promotes the Transformation of Neutrophils from Pro-Inflammatory to Anti-Inflammatory Effects in Psoriasis Vulgaris. [PDF]
Clin Cosmet Investig DermatolChen W, Zhang J.
europepmc +3 more sources