High‐Mobility Group Box 1–Signaling Inhibition With Glycyrrhizin Prevents Cerebral T‐Cell Infiltration After Cardiac Arrest [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background High‐mobility group box 1 (HMGB1) is a major promotor of ischemic injuries and aseptic inflammatory responses. We tested its inhibition on neurological outcome and systemic immune response after cardiac arrest (CA) in rabbits.
Emilie Boissady +10 more
doaj +2 more sources
Glycyrrhizin alleviates contrast-induced acute kidney injury via inhibiting HMGB1-mediated renal tubular epithelial cells ferroptosis [PDF]
Renal FailureContrast-induced acute kidney injury (CI-AKI) is the third leading cause of AKI, but there are no effective preventive or therapeutic measures in clinical practice. Glycyrrhizin, a bioactive compound isolated from the Glycyrrhiza glabra L., exhibits anti-
Fang-yuan Tian +9 more
doaj +2 more sources
Glycyrrhizin Inhibits SARS-CoV-2 Entry into Cells by Targeting ACE2 [PDF]
Life, 2022 Coronavirus Disease 2019 (COVID-19) is a highly infectious and pathogenic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Ming-Feng He +11 more
doaj +2 more sources
The potential of glycyrrhizin and licorice extract in combating COVID-19 and associated conditions
Phytomedicine Plus, 2021 Background: Several recent studies have stated that glycyrrhizin and licorice extract are present in most traditional Chinese medicine formulas used against SARS-CoV-2 in China.
Adel A Gomaa
exaly +3 more sources
Glycyrrhizin Effectively Inhibits SARS-CoV-2 Replication by Inhibiting the Viral Main Protease
Viruses, 2021 The outbreak of SARS-CoV-2 developed into a global pandemic affecting millions of people worldwide. Despite one year of intensive research, the current treatment options for SARS-CoV-2 infected people are still limited. Clearly, novel antiviral compounds
Lukas van de Sand +2 more
exaly +3 more sources
Glycyrrhizin as a potential disease-modifying therapy for epilepsy: insights into targeting pyroptosis to exert neuroprotective and anticonvulsant effects [PDF]
Frontiers in PharmacologyBackgroundFor patients with epilepsy, antiseizure medication remains the primary treatment; however, it is ineffective in approximately 30% of cases. These patients experience progressive neuronal damage and poor outcomes.
Lei Wei +6 more
doaj +2 more sources
Exogenous ethanol treatment promotes glycyrrhizin accumulation in aseptically grown Glycyrrhiza uralensis seedlings [PDF]
Plant Signaling & BehaviorLicorice, the dried roots and rhizomes of Glycyrrhiza uralensis Fisch., is one of the most popular herbal medicines used globally. Glycyrrhizin is the primary bioactive component of licorice, exhibiting various pharmacological activities. Herein, we grew
Yuto Nishidono, Ken Tanaka
doaj +2 more sources
Glycyrrhizin protects against porcine endotoxemia through modulation of systemic inflammatory response [PDF]
, 2013 Wei Wang +6 more
core +3 more sources
Glycyrrhizin exerts antioxidative effects in H5N1 influenza A virus-infected cells and inhibits virus replication and pro-inflammatory gene expression. [PDF]
PLoS ONE, 2011 Glycyrrhizin is known to exert antiviral and anti-inflammatory effects. Here, the effects of an approved parenteral glycyrrhizin preparation (Stronger Neo-Minophafen C) were investigated on highly pathogenic influenza A H5N1 virus replication, H5N1 ...
Martin Michaelis +6 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Asthma is a common chronic respiratory disease, which causes inflammation and airway stenosis, leading to dyspnea, wheezing and chest tightness. Using transgelin-2 as a target, we virtually screened the lead compound glycyrrhizin from the self-built ...
Jian-Hong Qi +7 more
doaj +1 more source