Results 11 to 20 of about 13,136 (253)

Glycyrrhizin, an inhibitor of HMGB1 induces autolysosomal degradation function and inhibits Helicobacter pylori infection

Molecular Medicine, 2023
Background Helicobacter pylori is a key agent for causing gastric complications linked with gastric disorders. In response to infection, host cells stimulate autophagy to maintain cellular homeostasis. However, H. pylori have evolved the ability to usurp
Uzma Khan, Bipul Chandra Karmakar, Priyanka Basak, Sangita Paul, Animesh Gope, Deotima Sarkar, Asish Kumar Mukhopadhyay, Shanta Dutta, Sushmita Bhattacharya   +8 more
doaj   +2 more sources

Clinical Risk Factors of Licorice-Induced Pseudoaldosteronism Based on Glycyrrhizin-Metabolite Concentrations: A Narrative Review

Frontiers in Nutrition, 2021
Licorice, the dried root or stolon of Glycyrrhiza glabra or G. ularensis, is commonly used worldwide as a food sweetener or crude drug. Its major ingredient is glycyrrhizin.
Tetsuhiro Yoshino, Saori Shimada, Masato Homma, Toshiaki Makino, Masaru Mimura, Masaru Mimura, Kenji Watanabe   +6 more
doaj   +2 more sources

Glycyrrhizin-Based Hydrogels Accelerate Wound Healing of Normoglycemic and Diabetic Mouse Skin

Pharmaceutics, 2022
Efficient wound repair is crucial for mammalian survival. Healing of skin wounds is severely hampered in diabetic patients, resulting in chronic non-healing wounds that are difficult to treat.
Maarten A. Mees, Fleur Boone, Thomas Bouwen, Frederik Vanaerschot, Charlotte Titeca, Hanna-Kaisa Vikkula, Leen Catrysse, Anja Vananroye, Erin Koos, Stelios Alexandris, Sabine Rosenfeldt, Samuel Eyley, Joachim Koetz, Geert van Loo, Wim Thielemans, Esther Hoste   +15 more
doaj   +2 more sources

Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis

BMC Immunology, 2021
Background The anti-inflammatory effect of glycyrrhizin has been widely recognized, while the specific mechanism of glycyrrhizin in psoriasis remains poorly understood.
Huang Qiong, Ling Han, Nanxue Zhang, Huyan Chen, Kexiang Yan, Zhenghua Zhang, Ying Ma, Jinhua Xu   +7 more
doaj   +2 more sources

Network pharmacology and in vitro experimental verification unveil glycyrrhizin from glycyrrhiza glabra alleviates acute pancreatitis via modulation of MAPK and STAT3 signaling pathways

BMC Complementary Medicine and Therapies
Acute pancreatitis (AP) is a severe gastrointestinal inflammatory disease with increasing mortality and morbidity. Glycyrrhiza glabra, commonly known as Liquorice, is a widely used plant containing bioactive compounds like Glycyrrhizin, which possesses ...
Rui Zhang, Aiminuer Asikaer, Qi Chen, Fang Wang, Junjie Lan, Yang Liu, Linfang Hu, Huaye Zhao, Hongtao Duan   +8 more
doaj   +2 more sources

Glycyrrhizin Inhibits SARS-CoV-2 Entry into Cells by Targeting ACE2

Life, 2022
Coronavirus Disease 2019 (COVID-19) is a highly infectious and pathogenic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Ming-Feng He, Jian-Hui Liang, Yan-Ni Shen, Jin-Wen Zhang, Ying Liu, Kuang-Yang Yang, Li-Chu Liu, Junyi Wang, Qian Xie, Chun Hu, Xun Song, Yan Wang   +11 more
doaj   +2 more sources

Computational and In Vitro Experimental Investigations Reveal Anti-Viral Activity of Licorice and Glycyrrhizin against Severe Acute Respiratory Syndrome Coronavirus 2

Pharmaceuticals, 2021
Without effective antivirals, the COVID-19 pandemic will likely continue to substantially affect public health. Medicinal plants and phytochemicals are attractive therapeutic options, particularly those targeting viral proteins essential for replication ...
Ahmed M. Tolah, Lamya M. Altayeb, Thamir A. Alandijany, Vivek Dhar Dwivedi, Sherif A. El-Kafrawy, Esam I. Azhar   +5 more
doaj   +2 more sources

Acrolein Promotes Retinal Inflammation Through Macrophage Chemotaxis by Inducing CCL2 Production From Müller Cells. [PDF]

FASEB J
Patients with proliferative diabetic retinopathy show elevated vitreous levels of the acrolein adduct FDP‐lys and CCL2. In rat Müller glial cells (TR‐MUL5), acrolein increases Ccl2 gene expression and CCL2 secretion and promotes macrophage migration.
Fukutsu K, Murata M, Kikuchi K, Noda K, Ishida S.   +4 more
europepmc   +2 more sources

Glycyrrhizin exerts antioxidative effects in H5N1 influenza A virus-infected cells and inhibits virus replication and pro-inflammatory gene expression. [PDF]

PLoS ONE, 2011
Glycyrrhizin is known to exert antiviral and anti-inflammatory effects. Here, the effects of an approved parenteral glycyrrhizin preparation (Stronger Neo-Minophafen C) were investigated on highly pathogenic influenza A H5N1 virus replication, H5N1 ...
Martin Michaelis, Janina Geiler, Patrizia Naczk, Patchima Sithisarn, Anke Leutz, Hans Wilhelm Doerr, Jindrich Cinatl   +6 more
doaj   +1 more source

Glycyrrhizin [PDF]

Archiv der Pharmazie, 2020
A saponin-like compound that provides the main sweet flavor for Glycyrrhiza glabra (licorice), with potential immunomodulating, anti-inflammatory, hepato- and neuro-protective, and antineoplastic activities.
semanticscholar   +4 more sources