Results 21 to 30 of about 13,136 (253)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background High‐mobility group box 1 (HMGB1) is a major promotor of ischemic injuries and aseptic inflammatory responses. We tested its inhibition on neurological outcome and systemic immune response after cardiac arrest (CA) in rabbits.
Emilie Boissady +10 more
doaj +1 more source
Biomaterials Research, 2023 Background High-mobility group box-1 (HMGB1) released from the tumor microenvironment plays a pivotal role in the tumor progression. HMGB1 serves as a damaged-associated molecular pattern (DAMP) that induces tumor angiogenesis and its development ...
Hyung Shik Kim +3 more
semanticscholar +1 more source
Glycyrrhizin Inhibits PEDV Infection and Proinflammatory Cytokine Secretion via the HMGB1/TLR4-MAPK p38 Pathway [PDF]
International Journal of Molecular Sciences, 2020 Our previous study showed that glycyrrhizin (GLY) inhibited porcine epidemic diarrhea virus (PEDV) infection, but the mechanisms of GLY anti-PEDV action remain unclear.
Ruyi Gao +6 more
openalex +2 more sources
Glycyrrhizin inhibits LPS-induced inflammatory responses in goat ruminal epithelial cells in vitro
BMC Molecular and Cell Biology, 2023 Inflammation plays a crucial role in the progression of Subacute Ruminal Acidosis (SARA). The experiment was designed to investigate anti-inflammatory effects of glycyrrhizin on goats ruminal epithelial cells (GREC) which were induced SARA by ...
Junfeng Liu +6 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Asthma is a common chronic respiratory disease, which causes inflammation and airway stenosis, leading to dyspnea, wheezing and chest tightness. Using transgelin-2 as a target, we virtually screened the lead compound glycyrrhizin from the self-built ...
Jian-Hong Qi +7 more
doaj +1 more source
Glycyrrhizin suppresses epithelial-mesenchymal transition by inhibiting high-mobility group box1 via the TGF-β1/Smad2/3 pathway in lung epithelial cells [PDF]
PeerJ, 2020 Background Epithelial-mesenchymal transition (EMT) plays an important role in fibrosis, chronic inflammation, tumor metastasis, etc. Glycyrrhizin, an active component extracted from licorice plant, has been reported to treat a variety of inflammatory ...
Yanni Gui +5 more
doaj +2 more sources
Plant and Cell Physiology, 2023 Glycyrrhizin, a type of the triterpenoid saponin, is a major active ingredient contained in the roots of the medicinal plant licorice (Glycyrrhiza uralensis, G. glabra and G.
Naoki Chiyo +5 more
semanticscholar +1 more source
Pharmacology Research & Perspectives, 2021 Coronary microembolization (CME)‐induced inflammation and cardiomyocyte apoptosis are two key factors contributing to CME‐induced myocardial dysfunction.
Yonggang Yuan +3 more
doaj +1 more source
Cardioprotective Effect of Glycyrrhizin on Myocardial Remodeling in Diabetic Rats [PDF]
Biomolecules, 2021 Myocardial fibrosis is one of the major complications of long-term diabetes. Hyperglycemia induced cardiomyocyte atrophy is a frequent pathophysiological indicator of diabetic heart.
Vikram Thakur +4 more
openalex +2 more sources
Journal of Cosmetic Dermatology, 2023 Compound glycyrrhizin has achieved outstanding results in the treatment of various skin diseases. However, the use of mesotherapy to inject compound glycyrrhizin into the skin to treat acne is still understudied.
Yuxiang Chen +7 more
semanticscholar +1 more source