Results 1 to 10 of about 28 (28)
Advanced Science, EarlyView.An open‐source, low‐cost 3D perfusion system integrating bioprinted scaffolds and live‐imaging overcomes 2D culture limitations. Modeling the cerebrospinal fluid‐filled subarachnoid space, it reveals flow‐dependent focal adhesion kinase activation in meningothelial cells, demonstrating a powerful platform for studying mechanobiology and creating ...
Subashree Srinivasan +7 more
wiley +1 more source
Advanced Science, EarlyView.The N1 peptide specifically targets neurons, enabling cytosolic delivery of fluorescent dyes and proteins for super‐resolution imaging and functional genetic modification. Abstract Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research.
Xiaoqian Ge +16 more
wiley +1 more source
Contrast Agent Clearance Dynamics and Diffusion in the Mouse Brain After Ventricular Administration
Advanced Science, EarlyView.Schematic representation of contrast agent clearance by convective bulk flow from the ventricular spaces to the subarachnoid space on the ventral aspect of the brain, or by diffusion into the parenchyma across the pia‐glia or through the semi‐permeable ependyma. Abstract Fluid and solute exchange between cerebrospinal fluid (CSF) spaces and the central
Yann Decker +2 more
wiley +1 more source
Exploring biomarkers of neurodegeneration in epilepsy: Critical insights
Epileptic Disorders, EarlyView.Abstract The advent of biofluid biomarkers for neurodegenerative disorders has precipitated a surge in recent evidence regarding their role in epilepsy. In this literature review, we examine the diagnostic, prognostic, and therapeutic potential of several biomarkers, including amyloid‐beta (Aβ) protein, total (t‐tau), phosphorylated tau (p‐tau) protein,
Rida Farhan +7 more
wiley +1 more source
The rise of 3D bioprinting advancements in modeling neurodegenerative diseases
Ibrain, EarlyView.Modeling neurodegenerative diseases: 3D bioprinting as a strategy for replicating the complexity of brain architecture. Recent findings have demonstrated that 3D bioprinting platforms can be exploited to recreate the complex neural pattern, giving the possibility of controlling cell density and scaffold stiffness.
Lucia Iafrate, Gianluca Cidonio
wiley +1 more source
MR‐Guidance of Gene Therapy for Brain Diseases: Moving From Palliative Treatment to Cures
Journal of Magnetic Resonance Imaging, EarlyView.ABSTRACT Regulatory bodies in the U.S. and Europe recently approved a gene therapy for aromatic L‐amino acid decarboxylase (AADC) deficiency, a rare neurologic disorder where a genetic mutation prevents dopamine production in the brain. Affected children fail to develop normal motor and cognitive functions.
Dalton H. Bermudez +2 more
wiley +1 more source
Journal of Magnetic Resonance Imaging, EarlyView.ABSTRACT Background Imaging biomarkers for neuropsychiatric systemic lupus erythematosus (NPSLE) are highly needed, and intracranial contrast‐enhanced vessel wall imaging (CE‐VWI) can potentially detect cerebral vessel wall abnormalities in lupus. Purpose To evaluate the diagnostic value of CE‐VWI in differentiating NPSLE from non‐NPSLE.
Satoru Ide +9 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background The pathophysiology of idiopathic normal pressure hydrocephalus (iNPH) and its association with neurodegenerative disorders is poorly understood. Objectives The aim was to determine the prevalence of α‐synuclein pathology in iNPH and its associations with clinical characteristics. Methods We used α‐synuclein seed amplification assay
Sandrina Weber +9 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background The aim was to investigate if glymphatic function is impaired in patients with Huntington's disease (HD) and its clinical relevance. Methods Forty‐nine subjects carrying mutant Huntingtin (mHTT), comprising 35 manifest (mHD) and 14 pre‐manifest (PreHD), and 35 healthy controls (HC) were recruited in this study.
Jin‐Hui Yin +3 more
wiley +1 more source
Exercise‐Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart
Aging Cell, EarlyView.Exercise improves cardiac lymphatic architecture and function in the aged mouse. Aged hearts show reduced lymphatic vascular density, more dilated vessels, and increased peri‐lymphatic inflammation and fibrosis. Exercise training of the aged mouse increases lymph vessel density and sprouting, reverses their dilation, reduces inflammation and fibrosis ...
Kangsan Roh +19 more
wiley +1 more source