Results 91 to 100 of about 11,518 (273)

Age- and time-of-day dependence of glymphatic function in the human brain measured via two diffusion MRI methods

Frontiers in Aging Neuroscience, 2023
Advanced age, accompanied by impaired glymphatic function, is a key risk factor for many neurodegenerative diseases. To study age-related differences in the human glymphatic system, we measured the influx and efflux activities of the glymphatic system ...
Guangxu Han, Guangxu Han, Ying Zhou, Kemeng Zhang, Bingjie Jiao, Bingjie Jiao, Junwen Hu, Junwen Hu, Yifan Zhang, Yifan Zhang, Zejun Wang, Zejun Wang, Min Lou, Ruiliang Bai, Ruiliang Bai, Ruiliang Bai   +15 more
doaj   +1 more source

Functional abnormalities of the glymphatic system in cognitive disorders. [PDF]

Neural Regen Res
Various pathological mechanisms represent distinct therapeutic targets for cognitive disorders, but a balance between clearance and production is essential for maintaining the stability of the brain’s internal environment. Thus, the glymphatic system may represent a common pathway by which to address cognitive disorders.
Shentu W, Kong Q, Zhang Y, Li W, Chen Q, Yan S, Wang J, Lai Q, Xu Q, Qiao S.   +9 more
europepmc   +4 more sources

Investigation of the Determinants of Disease Severity in Patients with Idiopathic Normal Pressure Hydrocephalus

Movement Disorders Clinical Practice, EarlyView.
Background The determinants of the severity of idiopathic normal pressure hydrocephalus (iNPH) have not been examined previously. Objective To reveal the clinical determinants of the clinical severity of iNPH in detail. To provide some clinical remarks and contributions to the understanding of the pathophysiology.
Halil Onder, Ahmet Gunaydin, Nursu Erdogan, Selcuk Comoglu   +3 more
wiley   +1 more source

A Holistic Wellness Prescription for Parkinson's Disease: Evidence‐Based Perspectives and Unmet Needs

Movement Disorders Clinical Practice, EarlyView.
Abstract Background In modern medicine the concept of wellness is often accompanied by various misconceptions arising from several factors, including a lack of clear definitions, the commercialization of wellness, and prevailing biases and stereotypes.
Indu Subramanian, Lucia Ricciardi, Anette Schrag, Silke Appel‐Cresswell, Sushma Kola, Josefa M. Domingos, Barbara A. Pickut, Nabila Dahodwala, Abdoulaye Bocoum, Cristian Falup‐Pecurariu, Gila Bronner, Gregory M. Pontone, Laurie K. Mischley, Nélida S. Garretto, Nicola Modugno, Rachel Dolhun, Tissa Wijeratne, Victoria Tull, Bradley McDaniels, K. Ray Chaudhuri, the International Parkinson, Movement Disorder Society Task Force on Wellness, Indu Subramanian, Lucia Ricciardi, Anette Schrag, Silke Appel‐Cresswell, Sushma Kola, Josefa M. Domingos, Barbara A. Pickut, Nabila Dahodwala, Abdoulaye Bocoum, Cristian Falup‐Pecurariu, Gila Bronner, Gregory M. Pontone, Laurie K. Mischley, Nélida S. Garretto, Nicola Modugno, Rachel Dolhun, Tissa Wijeratne, Victoria Tull, K. Ray Chaudhuri   +40 more
wiley   +1 more source

The structure, functions and clinical significance of the glymphatic system [PDF]

Eurasian Journal of Veterinary Sciences, 2021
The glymphatic system is a newly discovered waste cleaning system. It provides active removal of metabolites and soluble proteins from the central nervous system (CNS).
Tansu Kuşat, Emrah Sur
doaj  

The choroid plexus in health and in disease: dialogues into and out of the brain [PDF]

, 2017
This article brings the choroid plexus into the context of health and disease. It is remarkable that the choroid plexus, composed by a monolayer of epithelial cells that lie in a highly vascularized stroma, floating within the brain ventricles, gets so ...
Brito, Maria Alexandra, Marques, Fernanda, Neves, Margarida Correia, Pahnke, Jens, Palha, Joana Almeida, Santos, Cecilia, Sousa, João Carlos   +6 more
core   +1 more source

Glymphatic imaging using MRI [PDF]

, 2020
In recent years, the existence of a mass transport system in the brain via cerebrospinal fluid (CSF) or interstitial fluid (ISF) has been suggested by many studies.
101203, 101204, Naganawa, Shinji, Taoka, Toshiaki   +3 more
core   +1 more source

Impaired Glymphatic Clearance, Measured Using Diffusion Tensor Image Analysis Along the Perivascular Space (DTI‐ALPS), is Linked to Poor Cognitive Outcomes in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Impaired glymphatic clearance may contribute to pathological accumulations in Parkinson's (PD), but how it interacts with other processes causing dementia remains unclear. Diffusion tensor image analysis along the perivascular space (DTI‐ALPS) has been proposed as an indirect proxy for glymphatic clearance. Objectives To clarify DTI‐
Angeliki Zarkali, George Thomas, Ross Paterson, Naomi Hannaway, Ivelina Dobreva, Amanda J. Heslegrave, Elena Veleva, Henrik Zetterberg, Rimona S. Weil   +8 more
wiley   +1 more source

Poroelastic Modelling of CSF circulation via the incorporation of experimentally derived microscale water transport properties [PDF]

, 2017
We outline how multicompartmental poroelasticity is applied to the study of dementia. We utilize a 3D version of our poroelastic code to investigate the effects within parenchymal tissue.
Chou, D, Guo, L, Jensen, V, Nagelhus, EA, Omholt, SW, Ottersen, OP, Pettersen, KH, Thoren, AE, Tully, BJ, Vardakis, IC, Ventikos, Y, Vindedal, GF   +11 more
core  

Distinct AQP4 Alterations in Movement Disorders with Primary Synucleinopathy

Movement Disorders, EarlyView.
Abstract Background Aquaporin‐4 (AQP4) is involved in clearing amyloidogenic proteins, but it remains unexplored how it is comparatively altered in neuron‐ and oligodendrocyte‐predominant synucleinopathies. Objective The aim was to assess AQP4 protein localization and abundance in Parkinson's disease (PD) and multiple system atrophy (MSA).
Lingbing Wang, Onur Tanglay, Feifei Su, Hongyun Li, Jun Liu, Woojin S. Kim, Glenda M. Halliday, YuHong Fu   +7 more
wiley   +1 more source