Results 101 to 110 of about 11,518 (273)
Neural Regeneration ResearchCerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels, often leading to stroke and dementia.
Yuhui Ma, Yan Han
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Impaired Glymphatic Transport in Spontaneously Hypertensive Rats [PDF]
, 2019 The glymphatic system is a brainwide CSF transport system that uses the perivascular space for fast inflow of CSF. Arterial pulsations are a major driver of glymphatic CSF inflow, and hypertension that causes vascular pathologies, such as arterial ...
Benveniste, Helene +8 more
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Magnetic Resonance in Medicine, EarlyView.Abstract Purpose The aim of this work is to make the DTI along the perivascular space (DTI‐ALPS‐index) more robust with respect to region selection and the orientation of the head and fibers. We propose to address this matter by using the principal diffusion directions and an automated, atlas‐based region of interest (ROI) placement.
Ali Ajouz +5 more
wiley +1 more source
Glymphatic System Pathology and Neuroinflammation as Two Risk Factors of Neurodegeneration
CellsThe key to the effective treatment of neurodegenerative disorders is a thorough understanding of their pathomechanism. Neurodegeneration and neuroinflammation are mutually propelling brain processes.
Stanisław Szlufik +3 more
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Brain Pathology, EarlyView.Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li +7 more
wiley +1 more source
Neural Regeneration ResearchParkinson's disease is a common neurodegenerative disorder that is associated with abnormal aggregation and accumulation of neurotoxic proteins, including α-synuclein, amyloid-β, and tau, in addition to the impaired elimination of these neurotoxic ...
Yumei Yue +4 more
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Methods to study glymphatic system in the rodent brain during physiological and pathological processes [PDF]
, 2022 Over the past decade, our understanding of brain-waste clearance underwent a revolution after the discovery of the so-called glymphatic system. The glia-lymphatic (abbreviated, glymphatic) system was first described in 2012 as a paravascular macrosystem ...
Battistella, Roberta
core
The “Glymphatic-Lymphatic System Pathology” and a New Categorization of Neurodegenerative Disorders [PDF]
, 2021 Pasquale Gallina +3 more
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Neurofluid Dynamics and the Glymphatic System: A Neuroimaging Perspective
Korean Journal of Radiology, 2020 The glymphatic system hypothesis is a concept describing the clearance of waste products from the brain. The term "glymphatic system" combines the glial and lymphatic systems and is typically described as follows. The perivascular space functions as a conduit that drains cerebrospinal fluid (CSF) into the brain parenchyma.
Toshiaki Taoka, Shinji Naganawa
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Novel neuropathological observations in an adult with Dravet syndrome
Epilepsia, EarlyView.Abstract Dravet syndrome (DS) is a developmental and epileptic encephalopathy associated with pathogenic variants in the SCN1A gene. The neuropathological features of adult DS remain poorly understood. We report the postmortem findings of a 55‐year‐old woman with DS due to a confirmed SCN1A pathogenic variant leading to Nav1.1 loss of function ...
Danielle M. Andrade +7 more
wiley +1 more source