Results 111 to 120 of about 11,518 (273)

Neurosurgery and the glymphatic system

Acta Neurochirurgica
Abstract The discovery of the glymphatic system has fundamentally altered our comprehension of cerebrospinal fluid transport and the removal of waste from brain metabolism. In the past decade, since its initial characterization, research on the glymphatic system has surged exponentially.
openaire   +2 more sources

The diabetic brain and cognition [PDF]

, 2017
The prevalence of both Alzheimer’s disease (AD) and vascular dementia (VaD) is increasing with the aging of the population. Studies from the last several years have shown that people with diabetes have an increased risk for dementia and cognitive ...
Ali Sameh S., Bajenaru Ovidiu, Choi Mun Seong, Chopp Michael, Dermanovic-Dobrota Vesna, Grünblatt Edna, Jellinger Kurt A., Kamal Mohammad Amjad, Kamal Warda, Korczyn Amos D., Riederer Peter, Vécsei László, Wojszel Zyta Beata, Yaman Hakan, Zhang Zheng G.   +14 more
core   +1 more source

How About Glymphatic System Function in Patients With Migraine? [PDF]

, 2021
Dong Ah Lee, Bong Soo Park, Junghae Ko, Il Hwan Kim, Jin Han Park, Sihyung Park, Yoo Jin Lee, Kang Min Park   +7 more
openalex   +1 more source

Association between enlarged perivascular space (ePVS) density and stereo‐electroencephalography (SEEG) biomarkers of epileptogenicity

Epilepsia, EarlyView.
Abstract Objective We aim to explore the association between enlarged perivascular space (ePVS) density and stereo‐electroencephalography (SEEG) biomarkers of epileptogenicity. Methods We retrospectively analyzed consecutive SEEG patients from an Australian site.
Jacob Bunyamin, Benjamin Sinclair, Thanomporn Wittayacharoenpong, Parveen Sagar, William Pham, Zhibin Chen, Noam Bosak, Joshua Laing, Matthew Gutman, Martin Hunn, Patrick Kwan, Terence J. O'Brien, Meng Law, Andrew Neal   +13 more
wiley   +1 more source

Targeting TRPV4 to restore glymphatic system function and alleviate cerebral edema in ischemic stroke. [PDF]

Brain Pathol
After ischemic stroke, TRPV4 activation induces cerebral edema through the TRPV4‐RhoA‐MMP9 axis: RhoA upregulates MMP9, which cleaves β‐DG to impair membrane anchoring. Subsequent β‐DG loss triggers AQP4 depolarization, disrupting GS‐mediated water homeostasis.
Li Y, Zhou H, Xie J, Yu M, Ye G, Zhang Y, Li Z, Zhang K, Wu J, Xiao S, Zeng S, Chang Y, Huang K, Pan S.   +13 more
europepmc   +2 more sources

36 Literature review on the effects of acute and chronic alcohol use on the glymphatic transport system [PDF]

, 2021
Anne M. Bonnici-Mallia, Vidya Girishankar   +1 more
openalex   +1 more source

The glymphatic system and its role in cerebral homeostasis

Journal of Applied Physiology, 2020
The brain’s high bioenergetic state is paralleled by high metabolic waste production. Authentic lymphatic vasculature is lacking in brain parenchyma. Cerebrospinal fluid (CSF) flow has long been thought to facilitate central nervous system detoxification in place of lymphatics, but the exact processes involved in toxic waste clearance from the brain ...
Benveniste, Helene, Elkin, Rena, Heerdt, Paul, Koundal, Sunil, Xue, Yuechuan, Lee, Hedok, Wardlaw, Joanna, Tannenbaum, Allen   +7 more
openaire   +5 more sources

C1q neutralization during epileptogenesis attenuates complement‐mediated synaptic elimination and epileptiform activity

Epilepsia, EarlyView.
Abstract Objective Accumulating evidence indicates that aberrant C1q‐C3 complement signaling in microglia and astrocytes drives synaptic dysfunction and neuronal loss. C1q‐mediated synaptic dysfunction disrupts neuronal circuitry balance and can lead to network hyperexcitability in epilepsy.
Yoonyi Jeong, Hyun‐Kyoung Lim, Hayeon Kim, Juheon Lee, Siyoon Lee, Minah Suh   +5 more
wiley   +1 more source

Unchanged Early Diffusion Tensor Imaging Along Perivascular Space Index After Amyloid‐Targeting Disease‐Modifying Therapy in Alzheimer's Disease: A Preliminary Study

Journal of Magnetic Resonance Imaging, EarlyView.
Tatsushi Oura, Hiroyuki Tatekawa, Akitoshi Takeda, Ayako Omori, Natsuko Atsukawa, Shu Matsushita, Daisuke Horiuchi, Hirotaka Takita, Taro Shimono, Daiju Ueda, Yoshiaki Itoh, Yukio Miki   +11 more
wiley   +1 more source

The potential role of sleep quality in the relationship between glymphatic function and migraine frequency: Insights from a cross‐sectional study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study aimed to explore the association between glymphatic function, as assessed by the diffusion tensor imaging along perivascular space (DTI‐ALPS) index, and headache frequency in individuals with migraine. Additionally, it evaluated whether sleep quality modulates this relationship.
Raffaele Ornello, Federico Salfi, Maria Grazia Vittorini, Antonio Innocenzi, Federico De Santis, Federico Bruno, Francesca Pistoia, Michele Ferrara, Alessandra Splendiani, Simona Sacco   +9 more
wiley   +1 more source