Results 121 to 130 of about 12,498 (256)

Sleep, circadian rhythms, and the pathogenesis of Alzheimer Disease [PDF]

, 2015
Disturbances in the sleep–wake cycle and circadian rhythms are common symptoms of Alzheimer Disease (AD), and they have generally been considered as late consequences of the neurodegenerative processes.
Holtzman, David M, Musiek, Erik S, Xiong, David D   +2 more
core   +2 more sources

Choroid Plexus Aquaporins in CSF Homeostasis and the Glymphatic System: Their Relevance for Alzheimer’s Disease [PDF]

, 2023
Cristina Municio, Laura Carrero, Desireé Antequera, Eva Carro   +3 more
openalex   +1 more source

Neurosurgery and the glymphatic system

Acta Neurochirurgica
Abstract The discovery of the glymphatic system has fundamentally altered our comprehension of cerebrospinal fluid transport and the removal of waste from brain metabolism. In the past decade, since its initial characterization, research on the glymphatic system has surged exponentially.
openaire   +2 more sources

C1q neutralization during epileptogenesis attenuates complement‐mediated synaptic elimination and epileptiform activity

Epilepsia, EarlyView.
Abstract Objective Accumulating evidence indicates that aberrant C1q‐C3 complement signaling in microglia and astrocytes drives synaptic dysfunction and neuronal loss. C1q‐mediated synaptic dysfunction disrupts neuronal circuitry balance and can lead to network hyperexcitability in epilepsy.
Yoonyi Jeong, Hyun‐Kyoung Lim, Hayeon Kim, Juheon Lee, Siyoon Lee, Minah Suh   +5 more
wiley   +1 more source

Exploring the association between Alzheimer’s disease, oral health, microbial endocrinology and nutrition [PDF]

, 2017
Longitudinal monitoring of patients suggests a causal link between chronic periodontitis and the development of Alzheimer’s disease (AD). However, the explanation of how periodontitis can lead to dementia remains unclear.
Ahmed, Al-Qutub, Alice Harding, Bakarcic, Barr, Bawadi, Bazzano, Bergström, Bhattacharjee, Bonfim, Borrell, Brandscheid, Bravo, Brayne, Bredesen, Bredesen, Bredesen, Brown, Calder, Cannizzo, Carrasco-Benso, Carter, Cekici, Chen, Chen, Clark, Clarke, Courchesne-Loyer, Craft, Crane, Cunnane, Cunnane, Cunnane, Cunnane, Darveau, Daulatzai, Dehghan, Diaz Heijtz, Ding, Dodington, Dunn, Ebrahim, Emery, Engelhart, Estruch, Eussen, Evers, Foster, Galland, Genco, Grant, Greiner, Grossi, Górska, Hamasaki, Hara, Harcombe, Harding, Heo, Herath, Hession, Holmes, Hsu, Ide, Iliff, Jayaram, Joshipura, Kamer, Kamer, Kamma, Kaushik, Kerti, Kim, Kim, Kondo, Krasse, Krueger, Kullmann, Köbe, Larsen, LeRoith, Libby, Lin, Loesche, Loos, Luo, Lyte, Lyte, Marden, Martínez-Lapiscina, McDade, Miklossy, Miklossy, Miranda, Morris, Morris, Newport, Nonaka, Olsen, Olsen, O’Brien, Paganini-Hill, Park, Peedikayil, Persson, Peuhkuri, Pigeon, Pistollato, Poole, Poole, Poulose, Quinn, Ravnskov, Reger, Reid, Reife, Remington, Riccia, Rincon, Riviere, Rosenberg, Russ, Salas-Salvadó, Sarita J. Robinson, Schmidt, Schwingshackl, Schätzel, Selhub, Shai, Ship, Sim K. Singhrao, Singh, Singh, Singhrao, Slawik, Sparks Stein, Sprecher, Stein, StJohn Crean, Sudo, Taafe, Taguchi, Takahashi, Takayama, Tawse-Smith, Tezal, Thevenet, Toffanello, Toffanello, Ulrike Gonder, Varela-López, Volek, Waddington, Wang, Yao, Yesavage, Yurko-Mauro, Zambon, Zhan, Zhang, Zhao   +160 more
core   +2 more sources

The potential role of sleep quality in the relationship between glymphatic function and migraine frequency: Insights from a cross‐sectional study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study aimed to explore the association between glymphatic function, as assessed by the diffusion tensor imaging along perivascular space (DTI‐ALPS) index, and headache frequency in individuals with migraine. Additionally, it evaluated whether sleep quality modulates this relationship.
Raffaele Ornello, Federico Salfi, Maria Grazia Vittorini, Antonio Innocenzi, Federico De Santis, Federico Bruno, Francesca Pistoia, Michele Ferrara, Alessandra Splendiani, Simona Sacco   +9 more
wiley   +1 more source

Anatomy of spinal CSF loss in the American alligator (Alligator mississippiensis)

Journal of Anatomy, Volume 246, Issue 4, Page 575-584, April 2025.
India ink introduced into the cranial cerebrospinal fluid (CSF) compartment of Alligator diffuses along the spinal cord and exits the spinal compartment using perineural flow, resulting in a prominent “ink cuff” forming at the base of the spinal nerve. In Alligator, the region of the ink cuff is drained by a small lymphatic vessel.
Hadyn DeLeeuw, Michael Cramberg, Matthew Dille, Emily Pick, Mary Thompson, Bruce A. Young   +5 more
wiley   +1 more source

Microglia synchronizes with the circadian rhythm of the glymphatic system and modulates glymphatic system function

IUBMB Life
AbstractMicroglia, as immune cells in the central nervous system, possess the ability to adapt morphologically and functionally to their environment. Glymphatic system, the principal waste clearance system in the brain, exhibits circadian rhythms. However, the impact of microglia on the glymphatic system function remains unknown.
Ting Yang, Yan Tang, Xinghua Liu, Song Gong, Ensheng Yao   +4 more
openaire   +2 more sources

Sympathetic innervation of human cervical lymph nodes: A potential neuroimmunomodulatory target for the treatment of T‐cell‐driven autoimmune diseases like MS?

Journal of Anatomy, EarlyView.
Recent animal studies have shown that the sympathetic nervous system (SNS) prevents disease activity of EAE (Experimental autoimmune encephalomyelitis, animal model of Multiple Sclerosis [MS]), presumably through adrenergic activity in the deep cervical lymph nodes (DCLNs).
Christopher Kremer, Claire Mackaaij, Suzanne A. M. W. Verlinde‐Schellekens, Ronald L. A. W. Bleys, Cindy G. J. Cleypool   +4 more
wiley   +1 more source

Impediment of Cerebrospinal Fluid Drainage Through Glymphatic System in Glioma

, 2022
Dan Xu, Jie Zhou, Hao Mei, Huan Li, Wenbo Sun, Haibo Xu   +5 more
openalex   +1 more source