Results 131 to 140 of about 12,498 (256)

Decrease of excessive daytime sleepiness after shunt treatment for normal pressure hydrocephalus

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Sleepiness and apathy are often reported in patients with normal pressure hydrocephalus. However, research on outcomes after shunt surgery has mainly focused on the classical triad symptoms, that is, gait, cognition, and bladder dysfunction. This study aimed to describe the effects of shunt treatment on excessive daytime sleepiness and whether ...
Simon Lidén, Anna Lindam, Dan Farahmand, Anne‐Marie Landtblom, Katarina Laurell   +4 more
wiley   +1 more source

Cerebral and Peripheral Hemodynamics Across Wakefulness and NREM Sleep

Journal of Sleep Research, EarlyView.
ABSTRACT Wake/sleep‐related changes in cerebral hemodynamic oscillations are well established, but similar changes in peripheral hemodynamics remain largely understudied. Moreover, how the relationship between cerebral and peripheral hemodynamics varies across sleep–wake states is not well understood, despite evidence that these oscillations in the low‐
Vidhya V. Nair, Brianna R. Kish, Hideyuki Oshima, Qiuting Wen, Yunjie Tong, A. J. Schwichtenberg   +5 more
wiley   +1 more source

Confined spaces in space: Cerebral implications of chronic elevations of inspired carbon dioxide and implications for long‐duration space travel

Experimental Physiology, EarlyView.
Abstract Cerebrovascular regulation is critically dependent upon the arterial partial pressure of carbon dioxide (PaCO2${P_{{\mathrm{aC}}{{\mathrm{O}}_{\mathrm{2}}}}}$), owing to its effect on cerebral blood flow, tissue PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_{\mathrm{2}}}}}$, tissue proton concentration, cerebral metabolism and cognitive and neuronal ...
Jay M. J. R. Carr, Philip N. Ainslie, Trevor Day   +2 more
wiley   +1 more source

40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice

Cell Discovery
The glymphatic-lymphatic system is increasingly recognized as fundamental for the homeostasis of the brain milieu since it defines cerebral spinal fluid flow in the brain parenchyma and eliminates metabolic waste.
Xiaoting Sun, Liliana Dias, Chenlei Peng, Ziyi Zhang, Haoting Ge, Zejun Wang, Jiayi Jin, Manli Jia, Tao Xu, Wei Guo, Wu Zheng, Yan He, Youru Wu, Xiaohong Cai, Paula Agostinho, Jia Qu, Rodrigo A. Cunha, Xuzhao Zhou, Ruiliang Bai, Jiang-fan Chen   +19 more
doaj   +1 more source

Impaired Windkessel function and proximal aortic stiffness: Linking vascular ageing to cognitive decline

Experimental Physiology, EarlyView.
Abstract Central arterial stiffening, particularly of the proximal aorta, is increasingly recognised as a pivotal contributor to cardiovascular disease, dementia, and mild cognitive impairment. Loss of Windkessel function amplifies pulsatile pressure, reduces diastolic perfusion and accelerates microvascular damage in the brain.
Jun Sugawara, Hirofumi Tanaka
wiley   +1 more source

Physiological cerebrospinal fluid interactions between brain and eye structures are altered after long‐duration spaceflight

Experimental Physiology, EarlyView.
Abstract Long‐duration spaceflight represents an extreme challenge, triggering adaptive responses including spaceflight‐associated neuro‐ocular syndrome, characterized by diminished visual acuity and ocular changes, which is a significant health risk for Mars missions.
Ge Tang, Steven Jillings, Ben Jeurissen, Elena Tomilovskaya, Inna Nosikova, Alexandra Ryabova, Ekaterina Pechenkova, Viktor Petrovichev, Ilya Rukavishnikov, Stefan Sunaert, Paul M. Parizel, Lyudmila Makovskaya, Valentin Sinitsyn, Jan Sijbers, Jitka Annen, Steven Laureys, Angelique Van Ombergen, Seyed‐Ahmad Ahmadi, Floris L. Wuyts, Peter zu Eulenburg   +19 more
wiley   +1 more source

Dysfunctional Glymphatic System with Disrupted Aquaporin 4 Expression Pattern on Astrocytes Causes Bacterial Product Accumulation in the CSF during Pneumococcal Meningitis

, 2022
Jaqueline S. Generoso, Sigrun Thorsdottir, Allan Collodel, Diogo Dominguini, Roberta R. E. Santo, Fabrícia Petronilho, Tatiana Barichello, Federico Iovino   +7 more
openalex   +1 more source

Foreign body responses in central nervous system mimic natural wound responses and alter biomaterial functions [PDF]

, 2019
Biomaterials hold promise for diverse therapeutic applications in the central nervous system (CNS). Little is known about molecular factors that determine CNS foreign body responses (FBRs) in vivo , or about how such responses influence biomaterial ...
Ao, Yan, Deming, Timothy, Kim, Jae, O’Shea, Timothy, Sofroniew, Michael, Wollenberg, Alexander   +5 more
core   +1 more source

“Glymphatic” Neurodegeneration: Is Sleep the Missing Key?

Clinical and Translational Neuroscience
Robust evidence suggests that the glymphatic system plays a key role in preserving brain health. Indeed, its activity in maintaining homeostasis by clearing neurotoxic proteins such as beta-amyloid from the human brain is essential.
Luigi Ferini-Strambi, Maria Salsone
doaj   +1 more source

Ultrastructure of astrocytes using volume electron microscopy: A scoping review

The Journal of Physiology, EarlyView.
Abstract figure legend A complete overview on astrocyte ultrastructure with volume electron microscopy. The morphology of astrocytes under physiological and pathological conditions plays a role in brain homeostasis, synaptic activity and structural support, but their morphological complexity and heterogeneity are still poorly quantified.
Vanessa Chiappini, Maria Fernanda Veloz Castillo, Francesco Biancardi, Ferdinando Di Cunto, Pierre J. Magistretti, Alessandro Vercelli, Marco Agus, Corrado Calì   +7 more
wiley   +1 more source