Glaucoma: the retina and beyond [PDF]
, 2016 Over 60 million people worldwide are diagnosed with glaucomatous optic neuropathy, which is estimated to be responsible for 8.4 million cases of irreversible blindness globally.
Cordeiro, MF +4 more
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Aquaporin-4 Functionality and Virchow-Robin Space Water Dynamics: Physiological Model for Neurovascular Coupling and Glymphatic Flow. [PDF]
, 2017 The unique properties of brain capillary endothelium, critical in maintaining the blood-brain barrier (BBB) and restricting water permeability across the BBB, have important consequences on fluid hydrodynamics inside the BBB hereto inadequately ...
Igarashi, Hironaka +3 more
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Impaired brain glymphatic flow in experimental hepatic encephalopathy [PDF]
, 2018 Background & Aims: Neuronal function is exquisitely sensitive to alterations in the extracellular environment. In patients with hepatic encephalopathy (HE), accumulation of metabolic waste products and noxious substances in the interstitial fluid of the ...
Arias, Natalia +13 more
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Imaging glymphatic response to glioblastoma
Cancer Imaging, 2023 Background The glymphatic system actively exchanges cerebrospinal fluid (CSF) and interstitial fluid (ISF) to eliminate toxic interstitial waste solutes from the brain parenchyma.
Jasleen Kaur +11 more
doaj +1 more source
What Is the “Glymphatic System”?
Magnetic Resonance in Medical Sciences, 2023 Although the glymphatic system hypothesis is highly popular, it also lacks certain details. In this paper, an attempt was made to present a more clearly defined hypothesis, which is consistent with the past experiment results. The new hypothesis consists of (1) water flux in the brain parenchyma, (2) water and solutes pathway of the perivascular space,
openaire +4 more sources
MRI-Based Demonstration of the Normal Glymphatic System in a Human Population: A Systematic Review
Frontiers in Neurology, 2022 BackgroundThe glymphatic system has been described as one that facilitates the exchange between the cerebrospinal fluid (CSF) and interstitial fluid, and many recent studies have demonstrated glymphatic flow based on magnetic resonance imaging (MRI).
Min Kyoung Lee +3 more
doaj +1 more source
Astrocytic Ion Dynamics: Implications for Potassium Buffering and Liquid Flow [PDF]
, 2019 We review modeling of astrocyte ion dynamics with a specific focus on the implications of so-called spatial potassium buffering, where excess potassium in the extracellular space (ECS) is transported away to prevent pathological neural spiking.
A Destexhe +76 more
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MRI and glymphatic system [PDF]
Stroke and Vascular Neurology, 2019 Glymphatic system is newly discovered pseudolymphatic system in brain and it plays an important role in the removal of interstitial metabolic waste products. We discuss and review the role of glymphatic system in neurological diseases, especially focus on the potential of MRI modelling and its associated challenges to obtain useful new information ...
openaire +3 more sources
The Role of Glymphatic System in Alzheimer’s and Parkinson’s Disease Pathogenesis
Biomedicines, 2022 Alzheimer’s disease (AD) is the most common cause of neurodegenerative dementia, whilst Parkinson’s disease (PD) is a neurodegenerative movement disorder.
Francesca R. Buccellato +4 more
doaj +1 more source
Convective infux/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways [PDF]
, 2018 Tracers injected into CSF pass into the brain alongside arteries and out again. This has been recently termed the "glymphatic system" that proposes tracers enter the brain along periarterial "spaces" and leave the brain along the walls of veins.
Albargothy, Nazira J. +6 more
core +1 more source