Results 81 to 90 of about 11,518 (273)

Nanoscopic Mapping of the Extracellular Space in Amyloid Plaque‐rich Cortex

Advanced Science, EarlyView.
The extracellular space and diffusion around amyloid plaques are examined using shadow imaging and single‐particle tracking. Increased diffusivity is found near plaques, extracellular matrix alterations, and plaque core penetrability that varies with amyloid phenotype.
Juan Estaún‐Panzano, Yulia Dembitskaya, Ivo Calaresu, Somen Nandi, Quentin Gresil, Evelyne Doudnikoff, Thierry Leste‐Laserre, Thierry Amédée, Laurent Cognet, Laurent Groc, Urs Valentin Nägerl, Erwan Bezard   +11 more
wiley   +1 more source

NIR-II nanoprobes for investigating the glymphatic system function under anesthesia and stroke injury

Journal of Nanobiotechnology
The glymphatic system plays an important role in the transportation of cerebrospinal fluid (CSF) and the clearance of metabolite waste in brain. However, current imaging modalities for studying the glymphatic system are limited.
Bin Sun, Danlan Fang, Wenzhong Li, Mengfei Li, Shoujun Zhu   +4 more
doaj   +1 more source

A mixed finite element method for nearly incompressible multiple-network poroelasticity

, 2018
In this paper, we present and analyze a new mixed finite element formulation of a general family of quasi-static multiple-network poroelasticity (MPET) equations.
Lee, Jeonghun J., Mardal, Kent-Andre, Piersanti, Eleonora, Rognes, Marie E.   +3 more
core   +1 more source

The effects of peripheral and central high insulin on brain insulin signaling and amyloid-β in young and old APP/PS1 mice [PDF]

, 2016
Hyperinsulinemia is a risk factor for late-onset Alzheimer's disease (AD). In vitro experiments describe potential connections between insulin, insulin signaling, and amyloid-β (Aβ), but in vivo experiments are needed to validate these relationships ...
Caesar, Emily E, Holtzman, David M, Jiang, Hong, Keyser, Jennifer, Koscal, Lauren J, Macauley, Shannon L, Moritz, Will, Robinson, Grace O, Roh, Joseph, Stanley, Molly   +9 more
core   +2 more sources

Integrating Astrocytes in the Sleep–Wake Cycle: The Time Is Now

BioEssays, EarlyView.
Astrocytes actively regulate sleep homeostatic and circadian rheostatic processes, underpinning the sleep–wake cycle. By acting as context‐dependent integrators of internal state and rhythmic environmental inputs, they modulate the encoding properties of neuronal circuitries and contribute to salient temporal representations in the brain.
Marco Brancaccio
wiley   +1 more source

Targeting the glymphatic system to promote α-synuclein clearance: a novel therapeutic strategy for Parkinson’s disease

Neural Regeneration Research
The excessive buildup of neurotoxic α-synuclein plays a pivotal role in the pathogenesis of Parkinson’s disease, highlighting the urgent need for innovative therapeutic strategies to promote α-synuclein clearance, particularly given the current lack of ...
Xiaoyue Lian, Zhenghao Liu, Zuobin Gan, Qingshan Yan, Luyao Tong, Linan Qiu, Yuntao Liu, Jiang-fan Chen, Zhihui Li   +8 more
doaj   +1 more source

Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function [PDF]

, 2018
Prolonged intake of excessive amounts of ethanol is known to have adverse effects on the central nervous system (CNS). Here we investigated the effects of acute and chronic ethanol exposure and withdrawal from chronic ethanol exposure on glymphatic ...
Eberhardt, Allison, Hussain, Rashad, Lou, Nanhong, Lundgaard, Iben, Nedergaard, Maiken, Peng, Sisi, Reeves, Benjamin Cameron, Vinitsky, Hanna Sophia, Wang, Wei   +8 more
core   +2 more sources

Differential glymphatic dysfunction and memory correlation in temporal lobe epilepsy subtypes

Epilepsia Open, EarlyView.
Abstract Objective This study aims to evaluate the glymphatic system (GS) in different temporal lobe epilepsy (TLE) subtypes using diffusion tensor imaging analysis along the perivascular space (DTI‐ALPS) and to explore its correlation with clinical factors and memory performance.
Ruotong Chen, Hong Li, Pu Miao, Hongyi Ye, Xiao Chen, Yuyu Yang, Jinqi Zhou, Yihe Chen, Yi Ge, Chenmin He, Xiaotong Shao, Zijian Wang, Yuting Gong, Cong Chen, Shan Wang, Lingli Hu, Lingqi Ye, Yao Ding, Shuang Wang, Linglin Yang   +19 more
wiley   +1 more source

Tea and Blood–Brain Barrier Homeostasis: Potential Mechanisms and Improvement Strategies

Food Frontiers, EarlyView.
Abstract The blood–brain barrier (BBB), a selective interface regulating cerebral substance exchange, plays a crucial role in maintaining cognitive function and metabolic balance. While tea consumption has been traditionally associated with health benefits, its specific effects on BBB integrity warrant systematic investigation. This review demonstrates
Rongbosen Yue, Haitao Wen, Lian He, Yan Liu, Zeng Liang, Liyong Luo   +5 more
wiley   +1 more source

Exploring neurodegenerative disorders using advanced magnetic resonance imaging of the glymphatic system

Frontiers in Psychiatry
The glymphatic system, a macroscopic waste clearance system in the brain, is crucial for maintaining neural health. It facilitates the exchange of cerebrospinal and interstitial fluid, aiding the clearance of soluble proteins and metabolites and ...
Jannik Prasuhn, Jannik Prasuhn, Jannik Prasuhn, Jannik Prasuhn, Jannik Prasuhn, Jiadi Xu, Jiadi Xu, Jun Hua, Jun Hua, Peter van Zijl, Peter van Zijl, Linda Knutsson, Linda Knutsson, Linda Knutsson   +13 more
doaj   +1 more source