Results 51 to 60 of about 192,172 (285)

Innate immune modulation by GM-CSF and IL-3 in health and disease [PDF]

, 2019
Granulocyte-macrophage colony-stimulating factor (GM-CSF) and inteleukin-3 (IL-3) have long been known as mediators of emergency myelopoiesis, but recent evidence has highlighted their critical role in modulating innate immune effector functions in mice ...
Borriello F., Galdiero M. R., Loffredo S., Marone G., Spadaro G., Varricchi G.   +5 more
core   +1 more source

Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation [PDF]

, 2014
T(H)1 and T(H)17 cells mediate neuroinflammation in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. Pathogenic T(H) cells in EAE must produce the pro-inflammatory cytokine granulocyte-macrophage colony stimulating ...
Bradstreet, Tara R, Carrero, Javier A, Chou, Chun, Cook, Lindsey E, Edelson, Brian T, Egawa, Takeshi, Lin, Chih-Chung, Murphy, Theresa L, Russell, John H, Schwarzkopf, Elizabeth A, Sim, Julia, Taneja, Reshma   +11 more
core   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Clinical and biological heterogeneity in children with moderate asthma [PDF]

, 2003
To evaluate the relationship between inflammatory markers and severity of asthma in children, the amount of interleukin-8 (IL-8) and granulocyte/macrophage colony-stimulating factor (GM-CSF) released by peripheral blood mononuclear cells, exhaled nitric ...
Bellia, V, Bonsignore, G, Bousquet, J, Gagliardo, R, LA GRUTTA, Stefania, Mirabella, F, Pajno, G, Vignola, A.   +7 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Liver fibrosis and CD206+ macrophage accumulation are suppressed by anti-GM-CSF therapy

JHEP Reports, 2020
Background & Aims: Chronic liver inflammation leads to fibrosis and cirrhosis and is associated with an accumulation of intrahepatic TNFα-secreting CD206+ macrophages, which may participate in maintaining chronic liver disease in a GM-CSF-dependent ...
Alfonso Tan-Garcia, Fritz Lai, Joe Poh Sheng Yeong, Sergio E. Irac, Pei Y. Ng, Rasha Msallam, Jeffrey Chun Tatt Lim, Lu-En Wai, Christine Y.L. Tham, Su P. Choo, Tony Lim, Dan Y. Young, Roberta D'Ambrosio, Elisabetta Degasperi, Riccardo Perbellini, Evan Newell, Nina Le Bert, Florent Ginhoux, Antonio Bertoletti, Qingfeng Chen, Charles-Antoine Dutertre   +20 more
doaj   +1 more source

Racial Differences in the Effect of Granulocyte Macrophage Colony-Stimulating Factor on Improved Walking Distance in Peripheral Artery Disease: The PROPEL Randomized Clinical Trial. [PDF]

, 2019
Background The effects of race on response to medical therapy in people with peripheral artery disease ( PAD ) are unknown. Methods and Results In the PROPEL (Progenitor Cell Release Plus Exercise to Improve Functional Performance in PAD) Trial, PAD ...
Criqui, Michael H, Domanchuk, Kathryn, Ferrucci, Luigi, Guralnik, Jack M, Kibbe, Melina R, Li, Lingyu, McDermott, Mary M, Polonsky, Tamar S, Stein, James, Taylor, Doris A, Tian, Lu, Zhao, Lihui   +11 more
core   +1 more source

Gene rearrangements in bone marrow cells of patients with acute myelogenous leukemia [PDF]

, 2000
At diagnosis, clonal gene rearrangement probes {[}retinoic acid receptor (RAR)-alpha, major breakpoint cluster region (M-bcr), immunoglobulin (Ig)-JH, T cell receptor (TcR)-beta, myeloid lymphoid leukemia (MLL) or cytokine genes (GM-CSF, G-CSF, IL-3 ...
Braun, S., Duell, T., Gerhartz, Helmut Heinrich, Mittermueller, J., Schmetzer, Helga Maria, Wiesner, D.   +5 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

CREB regulates TNF-α-induced GM-CSF secretion via p38 MAPK in human lung fibroblasts

Allergology International, 2016
Background: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that mediates eosinophilic differentiation, migration and survival, causing respiratory tract inflammation.
Yasuhiko Koga, Takeshi Hisada, Tamotsu Ishizuka, Mitsuyoshi Utsugi, Akihiro Ono, Masakiyo Yatomi, Yosuke Kamide, Haruka Aoki-Saito, Hiroaki Tsurumaki, Kunio Dobashi, Masanobu Yamada   +10 more
doaj   +1 more source