Results 31 to 40 of about 332,782 (345)

Role of Granulocyte-Macrophage Colony-Stimulating Factor in Acute Myeloid Leukemia/Myelodysplastic Syndromes

Journal of Global Oncology, 2017
Purpose: Granulocyte-macrophage colony-stimulating factor (GM-CSF) cytokine stimulates growth, differentiation, and function of myeloid progenitors. We aimed to study the role of GM-CSF gene expression, its protein, and antibodies in patients with acute ...
Neemat M. Kassem, Alya M. Ayad, Noha M. El Husseiny, Doaa M. El-Demerdash, Hebatallah A. Kassem, Mervat M. Mattar   +5 more
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GM-CSF-Producing Th Cells in Rats Sensitive and Resistant to Experimental Autoimmune Encephalomyelitis. [PDF]

, 2016
Given that granulocyte macrophage colony-stimulating factor (GM-CSF) is identified as the key factor to endow auto-reactive Th cells with the potential to induce neuroinflammation in experimental autoimmune encephalomyelitis (EAE) models, the frequency ...
Mirjana Nacka-Aleksić (3342095), Zorica Stojić-Vukanić, Petrović Raisa, Ivan Pilipović, Petrović, Raisa, Nevena Arsenović-Ranin (3342104), Leposavić, Gordana, Leposavić Gordana, Vujnović, Ivana, Pilipović, Ivan, Zorica Stojić-Vukanić (3342101), Gordana Leposavić, Raisa Petrović, Gordana Leposavić (3342092), Arsenović-Ranin Nevena, Stojić-Vukanić, Zorica, Vujnović Ivana, Stojić-Vukanić Zorica, Raisa Petrović (3342089), Nacka-Aleksić Mirjana, Nevena Arsenović-Ranin, Mirjana Dimitrijević, Dimitrijević Mirjana, Mirjana Dimitrijević (3342086), Mirjana Nacka-Aleksić, Nacka-Aleksić, Mirjana, Ivana Vujnović (3342098), Arsenović-Ranin, Nevena, Pilipović Ivan, Ivana Vujnović, Ivan Pilipović (3342107), Dimitrijević, Mirjana   +31 more
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The Pleiotropic Effects of the GM-CSF Rheostat on Myeloid Cell Differentiation and Function: More Than a Numbers Game

Frontiers in Immunology, 2019
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is a myelopoietic growth factor that has pleiotropic effects not only in promoting the differentiation of immature precursors into polymorphonuclear neutrophils (PMNs), monocytes/macrophages (MØs)
Yifan Zhan, Yifan Zhan, Andrew M. Lew, Andrew M. Lew, Andrew M. Lew, Michael Chopin, Michael Chopin   +6 more
doaj   +1 more source

Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies

Frontiers in Immunology, 2020
COVID-19 is a clinical syndrome ranging from mild symptoms to severe pneumonia that often leads to respiratory failure, need for mechanical ventilation, and death.
Aldo Bonaventura, Aldo Bonaventura, Aldo Bonaventura, Alessandra Vecchié, Alessandra Vecchié, Tisha S. Wang, Elinor Lee, Paul C. Cremer, Brenna Carey, Prabalini Rajendram, Kristin M. Hudock, Kristin M. Hudock, Leslie Korbee, Benjamin W. Van Tassell, Lorenzo Dagna, Antonio Abbate, Antonio Abbate   +16 more
doaj   +1 more source

Studying the Effects of Granulocyte-Macrophage Colony-Stimulating Factor on Fetal Lung Macrophages During the Perinatal Period Using the Mouse Model

Frontiers in Pediatrics, 2021
Background: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pro-inflammatory cytokine that is increased in the amniotic fluid in chorioamnionitis and elevated in the fetal lung with endotoxin exposure. Although GM-CSF has a pivotal role in
Fook-Choe Cheah, Pietro Presicce, Pietro Presicce, Tian-Lee Tan, Brenna C. Carey, Suhas G. Kallapur, Suhas G. Kallapur   +6 more
doaj   +1 more source

Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes

Cell Reports, 2019
Summary: In recent years, the macrophage colony-stimulating factor (M-CSF) and granulocyte-macrophage CSF (GM-CSF) cytokines have been identified as opposing regulators of the inflammatory program. However, the two cytokines are simultaneously present in
Ramon M. Rodriguez, Beatriz Suarez-Alvarez, Jose L. Lavín, Alex M. Ascensión, Monika Gonzalez, Juan J. Lozano, Aroa B. Raneros, Paula D. Bulnes, Jose R. Vidal-Castiñeira, Covadonga Huidobro, Cristina Martin-Martin, Ana B. Sanz, Marta Ruiz-Ortega, Amaya Puig-Kröger, Angel L. Corbí, Marcos J. Araúzo-Bravo, Ana M. Aransay, Carlos Lopez-Larrea   +17 more
doaj   +1 more source

DataSheet_1_Recombinant GM-CSF for diseases of GM-CSF insufficiency: Correcting dysfunctional mononuclear phagocyte disorders.docx

, 2023
IntroductionEndogenous granulocyte-macrophage colony-stimulating factor (GM-CSF), identified by its ability to support differentiation of hematopoietic cells into several types of myeloid cells, is now known to support maturation and maintain the ...
Elizabeth Buchbinder (3526103), Michael Dougan (803043), David G. Armstrong (7433114), Robert Paine (807826), Elinor Lee (9082499), Carolyn E. Ragsdale (11280711), Hillard M. Lazarus (8553216), Tisha Wang (9909825), Edwin P. Rock (14317506), Robert Peter Gale (10333389), Katherine Pitts (14331309), Timothy Boyd (14331312)   +11 more
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Enlarged, activated alveolar macrophages as quantitative surrogates of disease activity in pulmonary sarcoidosis

Frontiers in Medicine
BackgroundIn pulmonary sarcoidosis, alveolar macrophages (AMs) undergo epithelioid transformation, but their quantitative morphologic characteristics and association with systemic disease markers remain incompletely defined.Research questionDo ...
Manabu Ishida, Takeshi Saraya, Nobutaka Kitamura, Koh Nakata, Haruyuki Ishii   +4 more
doaj   +1 more source

Neutralizing GM-CSF autoantibodies in pulmonary alveolar proteinosis, cryptococcal meningitis and severe nocardiosis

Respiratory Research, 2022
Background Anti GM-CSF autoantibodies (aAb) have been related to acquired pulmonary alveolar proteinosis (PAP) and described in cases of severe infections such as cryptococcosis and nocardiosis in previously healthy subjects.
Hélène Salvator, Aristine Cheng, Lindsey B. Rosen, Peter R. Williamson, John E. Bennett, Anuj. Kashyap, Li Ding, Kyung J. Kwon-Chung, Ho Namkoong, Christa S. Zerbe, Steven M. Holland   +10 more
doaj   +1 more source

GM-CSF as a novel inducer of NLRP2 expression

, 2021
thesis is about NRP2 proteins, which is one of the member of the intracellular PRR receptors. As our investigation showed, GM-CSF induces NLRP2 expression in monocytes and this process is dependent on STAT5/AKT but ERK signal transduction pathway has no ...
Trapaidze, Lizi
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