Results 21 to 30 of about 332,782 (345)
mBio, 2017 Mice deficient for granulocyte-macrophage colony-stimulating factor (GM-CSF−/−) are highly susceptible to infection with Mycobacterium tuberculosis, and clinical data have shown that anti-GM-CSF neutralizing antibodies can lead to increased ...
Alissa C. Rothchild +10 more
doaj +1 more source
, 2023 Macrophages play a critical role in the inflammatory response and tumor development. Macrophages are primarily divided into pro-inflammatory M1-like and anti-inflammatory M2-like macrophages based on their activation status and functions.
Qiaoling Song (365087) +10 more
core +1 more source
GM-CSF impairs erythropoiesis by disrupting erythroblastic island formation via macrophages
Journal of Translational Medicine, 2022 Anemia is a significant complication of chronic inflammation and may be related to dysregulated activities among erythroblastic island (EBI) macrophages.
Weijie Cao +13 more
doaj +1 more source
Cloning and eukaryotic expression of chicken granulocyte macrophage colony stimulating factor gene
浙江大学学报. 农业与生命科学版, 2009 In order to study the biological characteristics of chicken granulocyte macrophage colony stimulating factor (GM-CSF), Sichuan shandi black-bone chicken GM-CSF was amplified from ConA stimulated peripheral blood lymphocytes using RT-PCR.
TAN Bing +3 more
doaj +1 more source
The Role of Granulocyte-Macrophage Colony-Stimulating Factor in Murine Models of Multiple Sclerosis
Cells, 2020 Multiple sclerosis (MS) is an immune-mediated disease that predominantly impacts the central nervous system (CNS). Animal models have been used to elucidate the underpinnings of MS pathology.
Kelly L. Monaghan, Edwin C.K. Wan
doaj +1 more source
GM-CSF signalling boosts dramatically IL-1 production. [PDF]
PLoS ONE, 2011 GM-CSF is mostly known for its capacity to promote bone marrow progenitor differentiation, to mobilize and mature myeloid cells as well as to enhance host immune responses. However the molecular actions of GM-CSF are still poorly characterized.
Hanif Javanmard Khameneh +4 more
doaj +1 more source
GM‐CSF enhances tumor invasion by elevated MMP‐2, ‐9, and ‐26 expression
Cancer Medicine, 2013 Granulocyte–macrophage colony‐stimulating factor (GM‐CSF) promotes tumor progression in different tumor models in an autocrine and paracrine manner. However, at the same time GM‐CSF is used in cancer therapies to ameliorate neutropenia.
Claudia M. Gutschalk +5 more
doaj +1 more source
PLoS ONE, 2017 Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic, Th17-derived cytokine thought to critically contribute to the pathogenesis of diverse autoimmune diseases, including rheumatoid arthritis and psoriasis. Treatment with monoclonal
Tatjana Scholz +5 more
doaj +1 more source
GM-CSF activates HIF-1α to restrict M. tuberculosis in peritoneal macrophages.
, 2022 (A) CFU fold-change at d 4 postinfection for BMDMs and peritoneal macrophages treated with IFN-γ or 10 or 100 ng/mL GM-CSF. (B) CFU fold-change at d 5 postinfection for Ifngr-/- BMDMs co-cultured with wild-type or Csf2-/- lung CD4 T cells and GM-CSF. (C)
Sarah A. Stanley (525257) +8 more
core +1 more source
A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: outcomes at 2 years [PDF]
, 2012 The authors performed a randomised trial in very preterm small-for-gestational age (SGA) babies to determine if prophylaxis with granulocyte-macrophage colony-stimulating factor (GM-CSF) improves outcomes (the PROGRAMS trial).
Carr, R. +39 more
core +1 more source