Results 21 to 30 of about 122,634 (261)

Cloning and eukaryotic expression of chicken granulocyte macrophage colony stimulating factor gene

浙江大学学报. 农业与生命科学版, 2009
In order to study the biological characteristics of chicken granulocyte macrophage colony stimulating factor (GM-CSF), Sichuan shandi black-bone chicken GM-CSF was amplified from ConA stimulated peripheral blood lymphocytes using RT-PCR.
TAN Bing, WANG Hong-ning, ZHANG Yi, FAN Wen-qiao   +3 more
doaj   +1 more source

The Pleiotropic Effects of the GM-CSF Rheostat on Myeloid Cell Differentiation and Function: More Than a Numbers Game

Frontiers in Immunology, 2019
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is a myelopoietic growth factor that has pleiotropic effects not only in promoting the differentiation of immature precursors into polymorphonuclear neutrophils (PMNs), monocytes/macrophages (MØs)
Yifan Zhan, Yifan Zhan, Andrew M. Lew, Andrew M. Lew, Andrew M. Lew, Michael Chopin, Michael Chopin   +6 more
doaj   +1 more source

Studying the Effects of Granulocyte-Macrophage Colony-Stimulating Factor on Fetal Lung Macrophages During the Perinatal Period Using the Mouse Model

Frontiers in Pediatrics, 2021
Background: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pro-inflammatory cytokine that is increased in the amniotic fluid in chorioamnionitis and elevated in the fetal lung with endotoxin exposure. Although GM-CSF has a pivotal role in
Fook-Choe Cheah, Pietro Presicce, Pietro Presicce, Tian-Lee Tan, Brenna C. Carey, Suhas G. Kallapur, Suhas G. Kallapur   +6 more
doaj   +1 more source

Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies

Frontiers in Immunology, 2020
COVID-19 is a clinical syndrome ranging from mild symptoms to severe pneumonia that often leads to respiratory failure, need for mechanical ventilation, and death.
Aldo Bonaventura, Aldo Bonaventura, Aldo Bonaventura, Alessandra Vecchié, Alessandra Vecchié, Tisha S. Wang, Elinor Lee, Paul C. Cremer, Brenna Carey, Prabalini Rajendram, Kristin M. Hudock, Kristin M. Hudock, Leslie Korbee, Benjamin W. Van Tassell, Lorenzo Dagna, Antonio Abbate, Antonio Abbate   +16 more
doaj   +1 more source

Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes

Cell Reports, 2019
Summary: In recent years, the macrophage colony-stimulating factor (M-CSF) and granulocyte-macrophage CSF (GM-CSF) cytokines have been identified as opposing regulators of the inflammatory program. However, the two cytokines are simultaneously present in
Ramon M. Rodriguez, Beatriz Suarez-Alvarez, Jose L. Lavín, Alex M. Ascensión, Monika Gonzalez, Juan J. Lozano, Aroa B. Raneros, Paula D. Bulnes, Jose R. Vidal-Castiñeira, Covadonga Huidobro, Cristina Martin-Martin, Ana B. Sanz, Marta Ruiz-Ortega, Amaya Puig-Kröger, Angel L. Corbí, Marcos J. Araúzo-Bravo, Ana M. Aransay, Carlos Lopez-Larrea   +17 more
doaj   +1 more source

Enlarged, activated alveolar macrophages as quantitative surrogates of disease activity in pulmonary sarcoidosis

Frontiers in Medicine
BackgroundIn pulmonary sarcoidosis, alveolar macrophages (AMs) undergo epithelioid transformation, but their quantitative morphologic characteristics and association with systemic disease markers remain incompletely defined.Research questionDo ...
Manabu Ishida, Takeshi Saraya, Nobutaka Kitamura, Koh Nakata, Haruyuki Ishii   +4 more
doaj   +1 more source

GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function

Frontiers in Immunology, 2018
GM-CSF promotes myeloid differentiation of cultured bone marrow cells into cells of the granulocytic and monocytic lineage; the latter can further differentiate into monocytes/macrophages and dendritic cells.
Li Sun, Jai Rautela, Jai Rautela, Rebecca B. Delconte, Rebecca B. Delconte, Fernando Souza-Fonseca-Guimaraes, Fernando Souza-Fonseca-Guimaraes, Emma M. Carrington, Emma M. Carrington, Robyn L. Schenk, Robyn L. Schenk, Marco J. Herold, Marco J. Herold, Nicholas D. Huntington, Nicholas D. Huntington, Andrew M. Lew, Andrew M. Lew, Andrew M. Lew, Yuekang Xu, Yifan Zhan, Yifan Zhan, Yifan Zhan   +21 more
doaj   +1 more source

Neutralizing GM-CSF autoantibodies in pulmonary alveolar proteinosis, cryptococcal meningitis and severe nocardiosis

Respiratory Research, 2022
Background Anti GM-CSF autoantibodies (aAb) have been related to acquired pulmonary alveolar proteinosis (PAP) and described in cases of severe infections such as cryptococcosis and nocardiosis in previously healthy subjects.
Hélène Salvator, Aristine Cheng, Lindsey B. Rosen, Peter R. Williamson, John E. Bennett, Anuj. Kashyap, Li Ding, Kyung J. Kwon-Chung, Ho Namkoong, Christa S. Zerbe, Steven M. Holland   +10 more
doaj   +1 more source

Functional Granulocyte–Macrophage Colony-Stimulating Factor (GM-CSF) Delivered by Canine Histiocytic Sarcoma Cells Persistently Infected with Engineered Attenuated Canine Distemper Virus

Pathogens, 2023
The immune response plays a key role in the treatment of malignant tumors. One important molecule promoting humoral and cellular immunity is granulocyte–macrophage colony-stimulating factor (GM-CSF). Numerous successful trials have led to the approval of
Katarzyna Marek, Federico Armando, Thanaporn Asawapattanakul, Vanessa Maria Nippold, Philippe Plattet, Gisa Gerold, Wolfgang Baumgärtner, Christina Puff   +7 more
doaj   +1 more source

Malaria Pigment Hemozoin Impairs GM-CSF Receptor Expression and Function by 4-Hydroxynonenal

Antioxidants, 2021
Malarial pigment hemozoin (HZ) generates the lipoperoxidation product 4-hydroxynonenal (4-HNE), which is known to cause dysregulation of the immune response in malaria. The inhibition of granulocyte macrophage colony-stimulating factor (GM-CSF)-dependent
Oleksii Skorokhod, Valentina Barrera, Giorgia Mandili, Federica Costanza, Elena Valente, Daniela Ulliers, Evelin Schwarzer   +6 more
doaj   +1 more source