Results 11 to 20 of about 122,634 (261)
Adverse prognosis of GM-CSF expression in human cutaneous melanoma [PDF]
Neoplasia: An International Journal for Oncology ResearchBackground: GM-CSF, a myeloid-priming cytokine, exhibits context-dependent effects on tumor growth and, despite its clinical use, its role in human melanoma remains undefined.
Elena García-Martínez +8 more
doaj +2 more sources
GM-CSF production by immune cells in steady state and autoimmune neuroinflammation mapped using fate reporting mice [PDF]
Frontiers in ImmunologyIntroductionGM-CSF is a pro-inflammatory cytokine that promotes an inflammatory phenotype in myeloid cells. The extent and pattern of GM-CSF expression in immune cells have not been fully elucidated.
Gholamreza Azizi +7 more
doaj +2 more sources
The Journal of Immunology, 2017 With the cloning of the cDNA encoding murine GM-CSF in 1984, Dunn and colleagues ([1][1]) ushered the power of recombinant DNA technology into the exploration of the biology of this multifaceted cytokine.
openaire +2 more sources
Respiratory Research, 2018 Background Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare pulmonary disease caused by functional deficiency of granulocyte-macrophage colony-stimulating factor (GM-CSF). GM-CSF therapy in aPAP has been reported effective in some studies. This
Gaohong Sheng +5 more
doaj +1 more source
GM-CSF signalling boosts dramatically IL-1 production. [PDF]
PLoS ONE, 2011 GM-CSF is mostly known for its capacity to promote bone marrow progenitor differentiation, to mobilize and mature myeloid cells as well as to enhance host immune responses. However the molecular actions of GM-CSF are still poorly characterized.
Hanif Javanmard Khameneh +4 more
doaj +1 more source
PLoS ONE, 2017 Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic, Th17-derived cytokine thought to critically contribute to the pathogenesis of diverse autoimmune diseases, including rheumatoid arthritis and psoriasis. Treatment with monoclonal
Tatjana Scholz +5 more
doaj +1 more source
The Role of Granulocyte-Macrophage Colony-Stimulating Factor in Murine Models of Multiple Sclerosis
Cells, 2020 Multiple sclerosis (MS) is an immune-mediated disease that predominantly impacts the central nervous system (CNS). Animal models have been used to elucidate the underpinnings of MS pathology.
Kelly L. Monaghan, Edwin C.K. Wan
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GM‐CSF enhances tumor invasion by elevated MMP‐2, ‐9, and ‐26 expression
Cancer Medicine, 2013 Granulocyte–macrophage colony‐stimulating factor (GM‐CSF) promotes tumor progression in different tumor models in an autocrine and paracrine manner. However, at the same time GM‐CSF is used in cancer therapies to ameliorate neutropenia.
Claudia M. Gutschalk +5 more
doaj +1 more source
Journal of Global Oncology, 2017 Purpose: Granulocyte-macrophage colony-stimulating factor (GM-CSF) cytokine stimulates growth, differentiation, and function of myeloid progenitors. We aimed to study the role of GM-CSF gene expression, its protein, and antibodies in patients with acute ...
Neemat M. Kassem +5 more
doaj +1 more source
GM-CSF impairs erythropoiesis by disrupting erythroblastic island formation via macrophages
Journal of Translational Medicine, 2022 Anemia is a significant complication of chronic inflammation and may be related to dysregulated activities among erythroblastic island (EBI) macrophages.
Weijie Cao +13 more
doaj +1 more source