Results 11 to 20 of about 332,782 (345)
Recombinant GM-CSF for diseases of GM-CSF insufficiency: Correcting dysfunctional mononuclear phagocyte disorders [PDF]
Frontiers in Immunology, 2023 IntroductionEndogenous granulocyte-macrophage colony-stimulating factor (GM-CSF), identified by its ability to support differentiation of hematopoietic cells into several types of myeloid cells, is now known to support maturation and maintain the ...
Hillard M. Lazarus +15 more
doaj +4 more sources
GM-CSF Primes Proinflammatory Monocyte Responses in Ankylosing Spondylitis
Frontiers in Immunology, 2020 Objectives: GM-CSF is a pro-inflammatory cytokine with multiple actions predominantly on myeloid cells. Enhanced GM-CSF expression by lymphocytes from patients with Ankylosing Spondylitis (AS) has recently been described, however, its potential ...
Hui Shi +7 more
doaj +3 more sources
M-CSF and GM-CSF Regulation of STAT5 Activation and DNA Binding in Myeloid Cell Differentiation is Disrupted in Nonobese Diabetic Mice [PDF]
Clinical and Developmental Immunology, 2008 Defects in macrophage colony-stimulating factor (M-CSF) signaling disrupt myeloid cell differentiation in nonobese diabetic (NOD) mice, blocking myeloid maturation into tolerogenic antigen-presenting cells (APCs).
B. Rumore-Maton +6 more
openalex +2 more sources
Chimeric HIV-1 Envelope Glycoproteins with Potent Intrinsic Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Activity* [PDF]
PLoS ONE, 2013 HIV-1 acquisition can be prevented by broadly neutralizing antibodies (BrNAbs) that target the envelope glycoprotein complex (Env). An ideal vaccine should therefore be able to induce BrNAbs that can provide immunity over a prolonged period of time, but ...
Gözde Isik +5 more
openalex +3 more sources
Frontiers in Immunology, 2022 GM-CSF is an important cytokine that regulates the proliferation of monocytes/macrophages and its various functions during health and disease. Although growing evidences support the notion that GM-CSF could play a major role in immunity against ...
Abhishek Mishra +6 more
doaj +1 more source
Dense GM-CSFRα-expressing immune infiltration is allied with longer survival of intrahepatic cholangiocarcinoma patients [PDF]
PeerJ, 2023 Background Intrahepatic cholangiocarcinoma (iCCA) is a cancer arising from intrahepatic bile duct epithelium. An iCCA incidence is increasing worldwide; however, the outcome of the disease is dismal.
Paksiree Saranaruk +9 more
doaj +2 more sources
Indian Journal of Transplantation, 2021 Introduction: Hemorrhagic cystitis (HC) is a well-known complication in patients undergoing hematopoeitic stem cell transplantation (HSCT), contributing considerably to morbidity and prolonged hospital stay.
Akanksha Garg +4 more
doaj +1 more source
Adverse prognosis of GM-CSF expression in human cutaneous melanoma. [PDF]
NeoplasiaBackground: GM-CSF, a myeloid-priming cytokine, exhibits context-dependent effects on tumor growth and, despite its clinical use, its role in human melanoma remains undefined.
García-Martínez E +8 more
europepmc +2 more sources
Generation and utilization of a HEK-293T murine GM-CSF expressing cell line.
PLoS ONE, 2021 Macrophages and dendritic cells (DCs) are innate immune cells that play a key role in defense against pathogens. In vitro cultures of bone marrow-derived macrophages (BMDMs) and dendritic cells (BMDCs) are well-established and valuable methods for ...
Elektra Kantzari Robinson +3 more
doaj +1 more source
Respiratory Research, 2018 Background Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare pulmonary disease caused by functional deficiency of granulocyte-macrophage colony-stimulating factor (GM-CSF). GM-CSF therapy in aPAP has been reported effective in some studies. This
Gaohong Sheng +5 more
doaj +1 more source