Results 81 to 90 of about 192,172 (285)

An epithelial-to-mesenchymal transition-inducing potential of granulocyte macrophage colony-stimulating factor in colon cancer

Scientific Reports, 2017
Growing evidence shows that granulocyte macrophage colony-stimulating factor (GM-CSF) has progression-promoting potentials in certain solid tumors, which is largely attributed to the immunomodulatory function of this cytokine in tumor niches.
Yaqiong Chen, Zhi Zhao, Yu Chen, Zhonglin Lv, Xin Ding, Renxi Wang, He Xiao, Chunmei Hou, Beifen Shen, Jiannan Feng, Renfeng Guo, Yan Li, Hui Peng, Gencheng Han, Guojiang Chen   +14 more
doaj   +1 more source

Evaluation of soluble expression of recombinant granulocyte macrophage stimulating factor (rGM-CSF) by three different E. coli strains

Research in Pharmaceutical Sciences, 2020
Background and purpose: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine with a wide range of therapeutic applications although expression of GM-CSF in Escherichia coli (E.
Sina Soheili, Ali Jahanian-Najafabadi, Vajihe Akbari   +2 more
doaj   +1 more source

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +8 more
wiley   +1 more source

Cytokine Production but Lack of Proliferation in Peripheral Blood Mononuclear Cells from Chronic Chagas' Disease Cardiomyopathy Patients in Response to T. cruzi Ribosomal P Proteins [PDF]

, 2014
Background:Trypanosoma cruzi ribosomal P proteins, P2β and P0, induce high levels of antibodies in patients with chronic Chagas' disease Cardiomyopathy (CCC).
A Moncayo, A Rassi Jr, AC Arnholdt, Alcinette Buying, ARL Teixeira, AS de Melo, Augusto Atienza, B Zingales, C Aznar, C Chen, C Junqueira, C Smulski, Carlos A. Buscaglia, Clemencia Pinilla, CR De Marchi, E Cunha-Neto, E Mahler, E Mahler, E Olivares Fontt, E Olivares Fontt, E Roffê, EA Mesri, EB Gomez, F Kierszenbaum, F Nagajyothi, GE Cánepa, Graciela Perez Prados, GV Levy, I Ferrari, J Scharfstein, J Zhu, JA Fiuza, JAS Gomes, JC Coura, JM Burgos, JM Di Noia, JR Coura, K Elkon, Karina A. Gómez, KM Bonney, Laura M. Tasso, LC Abel, M Juri Ayub, M Ribeirao, MA Zacks, Mauricio Martins Rodrigues, MB Rosenbaum, MJ Morato, MV Elizari, NA Giraldo, P Lopez Bergami, P Lopez-Bergami, PA Chiale, Pablo Chiale, Radleigh Santos, RCG Fares, Ricardo Bonato, S Brandariz, S de Barros-Mazon, S Muller, Silvia A. Longhi, SL Topalian, V Judkowski, V Michailowsky, V Schultena, Valeria A. Judkowski, Virginia Balouz, VMB Lorena, WO Dutra, WO Dutra, WO Dutra, WO Dutra, WR Cuna, Y Belkaid, Y Morán-Utrera, Y Shi   +75 more
core   +4 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Functional Redundancy of Class I Phosphoinositide 3-Kinase (PI3K) Isoforms in Signaling Growth Factor-Mediated Human Neutrophil Survival [PDF]

, 2012
We have investigated the contribution of individual phosphoinositide 3-kinase (PI3K) Class I isoforms to the regulation of neutrophil survival using (i) a panel of commercially available small molecule isoform-selective PI3K Class I inhibitors, (ii ...
Alison M. Condliffe, Andrew S. Cowburn, Charaf Benarafa, Charles E. Owen, Edwin R. Chilvers, Ian Bruce, Jatinder K. Juss, Keith B. Boyle, Len Stephens, Phillip T. Hawkins, Richard P. Hayhoe, Sarah R. Walmsley, Suhasini Kulkarni   +12 more
core   +3 more sources

GM-CSF and proteinosis [PDF]

Thorax, 2003
The use of recombinant GM-CSF in the treatment of pulmonary alveolar proteinosis (PAP) has been reported recently in Thorax 1,2 in cases with anti-GM-CSF antibodies. We report the successful use of GM-CSF in a patient with no GM-CSF antibodies, which provides further evidence for considering GM-CSF as a possible keystone to the treatment of PAP.
openaire   +1 more source

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah, Sangmee S. Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source

Spleen‐Targeting Biomimetic Hybrid Nanocarriers for Systemic Immune Reprogramming in Colitis: RBC Membrane Vesicle‐Fused Lipid Nanoparticles

Advanced Functional Materials, EarlyView.
A spleen‐targeting hybrid nanoplatform (RBCMV‐LNP‐RP) harnessing erythrophagocytosis mimics senescent red blood cell clearance to achieve spleen‐specific delivery of rapamycin. This biomimetic system enables selective accumulation in splenic macrophages, orchestrating systemic immune reprogramming and promoting mucosal healing in an inflammatory bowel ...
Jun Kwon, Hee Su Sohn, Jong Sang Yoon, So Won Jeon, Hee Gyeong Ko, Min‐Ho Kang, Jisun Lee, Jae‐Hwan Nam, Louis T. Merriam, Edy Y. Kim, Han Young Kim   +10 more
wiley   +1 more source

In vitro production of functional immune cells derived from human hematopoietic stem cells [PDF]

, 2015
Hematopoietic stem cells (HSC) from cord blood are potentially high sources for transplantation due to their low immunogenicity and the presence of the multipotent cells.
Chalermsaenyakorn, Panus, Charoenphon, Natthawut, Jaovisidha, Adithep, Panichakul, Tasanee, Payuhakrit, Witchuda, Udomsangpetch, Rachanee, Wongborisuth, Chokdee   +6 more
core   +1 more source