Results 101 to 110 of about 332,782 (345)

MDSCs are involved in the protumorigenic potentials of GM-CSF in colitis-associated cancer

International Journal of Immunopathology and Pharmacology, 2017
Chronic inflammation is thought to be a major driving force for the development of colitis-associated colorectal cancer (CAC). As one member of proinflammatory cytokine family, granulocyte macrophage colony-stimulating factor (GM-CSF) has been identified
Ning Ma, Qilin Liu, Lin Hou, Yalin Wang, Ziling Liu   +4 more
doaj   +1 more source

Increased Frequency of Peripheral B and T Cells Expressing Granulocyte Monocyte Colony-Stimulating Factor in Rheumatoid Arthritis Patients

Frontiers in Immunology, 2018
ObjectivesGranulocyte monocyte colony-stimulating factor (GM-CSF) is currently considered a crucial inflammatory mediator and a novel therapeutic target in rheumatoid arthritis (RA), despite the fact that its precise cellular sources remain uncertain. We
Anastasia Makris, Sofia Adamidi, Christos Koutsianas, Christina Tsalapaki, Emilia Hadziyannis, Dimitrios Vassilopoulos   +5 more
doaj   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Image_1_Cxxc Finger Protein 1 Positively Regulates GM-CSF-Derived Macrophage Phagocytosis Through Csf2rα-Mediated Signaling.tif

, 2018
Macrophages have a defensive function against bacteria through phagocytosis and the secretion of cytokines. Histone modifications play an essential role in macrophage functions.
Wei Li (7081), Zhaoyuan Hui (117333), Xia Liu (117318), Shenghui Hong (5625899), Linrong Lu (830352), Jianli Wang (1305390), Zhonghui Xue (5625890), Lina Zhou (473857), Di Wang (329735), Lingfeng Zhou (5625893), Lie Wang (117337), Feng Lin (23861), Yikai Luo (5625896)   +12 more
core   +1 more source

Neutrophil GM-CSF receptor dynamics in acute lung injury. [PDF]

, 2019
GM-CSF is important in regulating acute, persistent neutrophilic inflammation in certain settings, including lung injury. Ligand binding induces rapid internalization of the GM-CSF receptor (GM-CSFRα) complex, a process essential for signaling.
Cohen, E.S., Corkill, D.J., Devaprasad, Abhinandan, Sleeman, Matthew A., Pandit, A., De Alessandris, Silvia, Pandit, Aridaman, Wyatt, O., Finch, Donna K, Cowburn, Andrew S., Juss, Jatinder K, Ferguson, G John, Finch, Donna K., Cohen, E. Suzanne, Cowburn, Andrew S, Chilvers, E.R., Chilvers, Edwin R, Finch, D.K., Simmonds, Rosalind, Cowburn, A.S., Dodd, A.J., Chilvers, Edwin R., Radstake, T.R.D.J., Sleeman, M.A., Killick, Helen, Sleeman, Matthew A, Cohen, E Suzanne, Condliffe, Alison M., De Alessandris, S., Condliffe, A.M., Corkill, Dominic J, Radstake, Timothy RDJ, Juss, Jatinder K., Juss, J.K., Corkill, Dominic J., Dodd, Alison J., Wyatt, Owen, Dodd, Alison J, Radstake, Timothy R.D.J., Condliffe, Alison M, Ferguson, G.J., Devaprasad, A., Killick, H., Piper, Siân, Piper, S., Simmonds, R., Ferguson, G. John   +46 more
core   +1 more source

Data from Phase I/II Study of Oncolytic HSV^GM-CSF in Combination with Radiotherapy and Cisplatin in Untreated Stage III/IV Squamous Cell Cancer of the Head and Neck

, 2023
Kevin J. Harrington, Mohan Hingorani, Mary Anne Tanay, Jennifer Hickey, Shreerang Bhide, Peter Clarke, Louise C. Renouf, Khin Thway, Amen Sibtain, Iain A. McNeish, Kate Newbold, Howard Goldsweig, Robert S. Coffin, Christopher M. Nutting   +13 more
openalex   +1 more source

Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b

Frontiers in Immunology, 2018
Genome-wide association studies as well as lymphatic expression analyses have linked both Cbl-b and GM-CSF to human multiple sclerosis as well as other autoimmune diseases. Both Cbl-b and GM-CSF have been shown to play a prominent role in the development
Sebastian Peer, Giuseppe Cappellano, Giuseppe Cappellano, Natascha Hermann-Kleiter, Karin Albrecht-Schgoer, Reinhard Hinterleitner, Reinhard Hinterleitner, Gottfried Baier, Thomas Gruber   +8 more
doaj   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Hydrogel-Delivered GM-CSF Overcomes Nonresponsiveness to Hepatitis B Vaccine through the Recruitment and Activation of Dendritic Cells [PDF]

, 2010
Ho-Yuan Chou, Xi-Zhang Lin, Wen-Yu Pan, Ping-Yi Wu, Chia‐Ming Chang, Tsai‐Yu Lin, Hsin-Hsin Shen, Mi‐Hua Tao   +7 more
openalex   +1 more source

A Review of GM-CSF Therapy in Sepsis

Medicine, 2015
Determine what clinical role, if any, GM-CSF may have in the clinical treatment of sepsis in the adult patient. Advancements in the management of sepsis have led to significant decreases in early mortality; however, sepsis remains a significant source of long-term mortality and disability which places strain on healthcare resources with a substantial ...
Mathias, Brittany, Szpila, Benjamin E., Moore, Frederick A., Efron, Philip A., Moldawer, Lyle L.   +4 more
openaire   +2 more sources