Results 91 to 100 of about 332,782 (345)

Osteoclastic potential of human CFU-GM: biphasic effect of GM-CSF

, 2004
UNLABELLED: Human osteoclasts can be efficiently generated in vitro from cord blood mononuclear cells and derived CFU-GM colonies. However, CFU-M colonies are poorly osteoclastogenic.
DE Myers (14652437), CM Lopez (7766096), GC Nicholson (14448297), JM Hodge (14447907), BE Adams (15885266), MA Kirkland (14448294), CJ Aitken (14652431), CM Waugh (15885263)   +7 more
core  

GM-CSF Treatment Schedule.

, 2013
GM-CSF Treatment Schedule.
Joris Veltman (431438), Jordan Dimitrakoff (431442), Adam P. Fagin (147181), Theo S. Plantinga (164719), Emeric F. Bojarski (431436), Mihai G. Netea (105648), Alexander Hoischen (195016), Adam C. Strauss (431437), Victor J. Anciano Granadillo (431440), Stephen A. Allsop (431439), Arsani William (431441)   +10 more
core   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Image_3_Cxxc Finger Protein 1 Positively Regulates GM-CSF-Derived Macrophage Phagocytosis Through Csf2rα-Mediated Signaling.tif

, 2018
Macrophages have a defensive function against bacteria through phagocytosis and the secretion of cytokines. Histone modifications play an essential role in macrophage functions.
Wei Li (7081), Zhaoyuan Hui (117333), Xia Liu (117318), Shenghui Hong (5625899), Linrong Lu (830352), Jianli Wang (1305390), Zhonghui Xue (5625890), Lina Zhou (473857), Di Wang (329735), Lingfeng Zhou (5625893), Lie Wang (117337), Feng Lin (23861), Yikai Luo (5625896)   +12 more
core   +1 more source

GM-CSF promotes pro-inflammatory macrophage activation associated with Akt/mTOR signaling during experimental colitis

Frontiers in Immunology
BackgroundUlcerative colitis (UC) is an intestinal immune disorder of unknown etiology. Mounting evidence reveals a central role of macrophages in the hemostatic balance of gut immunity, and dysfunctional macrophages are associated with UC pathogenesis ...
Silan Shen, Silan Shen, Silan Shen, Kexin Chen, Kexin Chen, Kexin Chen, Lili Li, Lili Li, Lili Li, Mingshan Jiang, Mingshan Jiang, Mingshan Jiang, Yongbin Jia, Xiufeng Bai, Xiufeng Bai, Zhen Zeng, Zhen Zeng, Zhen Zeng, Chunxiang Ma, Chunxiang Ma, Chunxiang Ma, Yuan Dang, Yuan Dang, Yuan Dang, Kehan Hu, Kehan Hu, Kehan Hu, Yanqiong Chen, Yanqiong Chen, Wenting Zhang, Wenting Zhang, Zhiyong Miao, Zhiyong Miao, Linlin Chen, Hu Zhang, Hu Zhang, Hu Zhang   +36 more
doaj   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Image_2_Cxxc Finger Protein 1 Positively Regulates GM-CSF-Derived Macrophage Phagocytosis Through Csf2rα-Mediated Signaling.tif

, 2018
Macrophages have a defensive function against bacteria through phagocytosis and the secretion of cytokines. Histone modifications play an essential role in macrophage functions.
Wei Li (7081), Zhaoyuan Hui (117333), Xia Liu (117318), Shenghui Hong (5625899), Linrong Lu (830352), Jianli Wang (1305390), Zhonghui Xue (5625890), Lina Zhou (473857), Di Wang (329735), Lingfeng Zhou (5625893), Lie Wang (117337), Feng Lin (23861), Yikai Luo (5625896)   +12 more
core   +1 more source

Tofacitinib inhibits granulocyte–macrophage colony-stimulating factor-induced NLRP3 inflammasome activation in human neutrophils

Arthritis Research & Therapy, 2018
Background Granulocyte–macrophage colony-stimulating factor (GM-CSF) has emerged as a crucial cytokine that activates myeloid cells to initiate tissue inflammation.
Makiko Yashiro Furuya, Tomoyuki Asano, Yuya Sumichika, Shuzo Sato, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Hideko Kozuru, Hiroshi Yatsuhashi, Tomohiro Koga, Hiromasa Ohira, Hideharu Sekine, Atsushi Kawakami, Kiyoshi Migita   +13 more
doaj   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

GM-CSF-secreting melanoma vaccines [PDF]

Oncogene, 2003
The development of biochemical and genetic schemes to characterize cancer antigens led to the recognition that malignant melanoma frequently evokes a host response. While the generation of brisk T-cell infiltrates in early stage disease is correlated with prolonged survival, host reactions in most cases are insufficient to impede tumor progression. One
openaire   +2 more sources