Results 171 to 180 of about 44,908 (222)
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Properties of Antisera to Ganglioside GM1 and Asialo GM1
The Journal of Immunology, 1974Abstract The object of this study is to prepare antisera to purified glycosphingolipids for immunocytochemical studies. Rabbits were immunized with ganglioside GM1 complexed either to methylated BSA or to a glycoprotein isolated from human erythrocytes, and to asialo GM1 complexed to the erythrocyte glycoprotein.
M, Naiki, D M, Marcus, R, Ledeen
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Carbohydrate Research, 1983
The 13C-n.m.r. spectra of asialo-GM1 and GM1-oligosaccharide are completely assigned and compared to those previously found for intact GM1 and for the series GM4, GM3, GM2, GM1, GD1a, GD1b, and GT1b. Removal of the ceramide residue from GM1 liberated a free, reducing aldehyde group, which was reflected in a doubling of the 13C-n.m.r. signals assignable
L O, Sillerud, R K, Yu
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The 13C-n.m.r. spectra of asialo-GM1 and GM1-oligosaccharide are completely assigned and compared to those previously found for intact GM1 and for the series GM4, GM3, GM2, GM1, GD1a, GD1b, and GT1b. Removal of the ceramide residue from GM1 liberated a free, reducing aldehyde group, which was reflected in a doubling of the 13C-n.m.r. signals assignable
L O, Sillerud, R K, Yu
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Hyperphosphatasemia in GM1 gangliosidosis
The Journal of Pediatrics, 1992info:eu-repo/semantics ...
Denis, Robert +5 more
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Neurochemical Research, 2012
Disruption of cholesterol metabolism has been hypothesized to contribute to dementia, possibly due to its role in maintaining membrane fluidity as well as the integrity of lipid rafts. Previously, we reported an apparent inverse relationship between membrane cholesterol levels and those of GM1, another lipid that can be found in rafts.
Cara-Lynne, Schengrund +2 more
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Disruption of cholesterol metabolism has been hypothesized to contribute to dementia, possibly due to its role in maintaining membrane fluidity as well as the integrity of lipid rafts. Previously, we reported an apparent inverse relationship between membrane cholesterol levels and those of GM1, another lipid that can be found in rafts.
Cara-Lynne, Schengrund +2 more
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Expression of the Gm1-Species, [NeuN]-GM1, in a Case of Human Glioma
Neurochemical Research, 1999Altered glycosylation is a common feature in tumors of various kind and particular interest has been focused on the expression of tumor-associated gangliosides. We have previously identified some human glioma-associated gangliosides and in this study yet another, not previously described, ganglioside has been isolated. The ganglioside was prepared from
P, Fredman +4 more
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Archives of Ophthalmology, 1971
THE PURPOSE of this paper is to present, for the first time, the ocular pathological manifestations of infantile or type 1 GM1-gangliosidosis (also known as generalized gangliosidosis). In addition, the clinical aspects of this disease will be discussed, since it has important ocular manifestations, but has received only one brief mention in the ...
J M, Emery +3 more
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THE PURPOSE of this paper is to present, for the first time, the ocular pathological manifestations of infantile or type 1 GM1-gangliosidosis (also known as generalized gangliosidosis). In addition, the clinical aspects of this disease will be discussed, since it has important ocular manifestations, but has received only one brief mention in the ...
J M, Emery +3 more
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Fuc-GM1 ganglioside mimics the receptor function of GM1 for cholera toxin
Biochemistry, 1992The ability of Fuc-GM1 ganglioside to mimic the receptor function of GM1 for cholera toxin (CT) has been investigated. For this purpose, rat glioma C6 cultured cells were enriched with Fuc-GM1 and the responsiveness to CT was compared with that of cells enriched with GM1 ganglioside.
MASSERINI, MASSIMO ERNESTO +4 more
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Genetic heterogeneity in GM1-gangliosidosis
Nature, 1975GM1-GANGLIOSIDOSIS is an inherited lysosomal storage disease which is due to a deficiency of the acid hydrolase GM1-β-galactosidase1. During the past few years several clinical variants have been described2–6 that differ in time of onset of symptoms, involvement of visceral organs or skeletal tissue and in the degree of neuronal and mental ...
H. GALJAARD +6 more
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GM1 gangliosidosis in shiba dogs
Veterinary Record, 2000A six‐month‐old shiba dog with a one‐month history of progressive motor dysfunction showed clinical signs of a cerebellar disorder, including ataxia, dysmetria and intention tremor of the head. Histopathological and ultrastructural studies revealed distended neurons packed with membranous cytoplasmic bodies throughout the central nervous system.
O, Yamato +8 more
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1989
GM1 gangliosidosis is an autosomal recessive disorder of GM1 metabolism, resulting in variable neural and visceral accumulation. Two forms can be distinguished: generalized or type 1 GM1 gangliosidosis and cerebral or type 2 GM1 gangliosidosis.
Marjo S. van der Knaap, Jacob Valk
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GM1 gangliosidosis is an autosomal recessive disorder of GM1 metabolism, resulting in variable neural and visceral accumulation. Two forms can be distinguished: generalized or type 1 GM1 gangliosidosis and cerebral or type 2 GM1 gangliosidosis.
Marjo S. van der Knaap, Jacob Valk
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