Results 51 to 60 of about 157,757 (356)

Outer membrane vesicles induce the mussel plantigrade settlement via regulation of c-di-GMP

, 2023
Despite the importance of outer membrane vesicles (OMVs) in benthic animal settlement, the underlying molecular mechanism remains elusive. Here, the impact of OMVs and OMVs synthesis-related tolB gene in Mytilus coruscus plantigrade settlement was tested.
Guanju Wu (16248608), Xiao-Meng Hu (11538277), Li-Hua Peng (1543093), Jin-Long Yang (417341), Sergey Dobretsov (472223), Xiao Liang (185891), Wen Zhang (7555)   +6 more
core   +1 more source

SV-BR-1-GM, a Clinically Effective GM-CSF-Secreting Breast Cancer Cell Line, Expresses an Immune Signature and Directly Activates CD4+ T Lymphocytes

Frontiers in Immunology, 2018
Targeted cancer immunotherapy with irradiated, granulocyte–macrophage colony-stimulating factor (GM-CSF)-secreting, allogeneic cancer cell lines has been an effective approach to reduce tumor burden in several patients. It is generally assumed that to be
Markus D. Lacher, Gerhard Bauer, Brian Fury, Sanne Graeve, Emily L. Fledderman, Tye D. Petrie, Dane P. Coleal-Bergum, Tia Hackett, Nicholas H. Perotti, Ying Y. Kong, William W. Kwok, Joseph P. Wagner, Charles L. Wiseman, William V. Williams   +13 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

miR-155-5p drives coordinated tumor and macrophage reprogramming across multiple cancer entities

BMC Medicine
Background T cell-based immunotherapies have improved cancer treatment, however their efficacy is frequently limited by tumor-intrinsic resistance mechanisms and by the immune suppressive tumor microenvironment, counteracting tumor specific immune ...
Theresa Kordaß, Ann-Katrin Schlosser, Marijan Czygan, Luisa Vieira Codeco Marques, Melisa Wartusch, Eric Nerenz, Vincencia Stefanie Muliawan, Stephan Kersting, Wolfram Osen, Stefan B. Eichmüller   +9 more
doaj   +1 more source

Simulasi Distribusi Fluks dan Tegangan Generator Magnet Permanen Satu-Fasa Hasil Modifikasi Motor Induksi Rotor Sangkar Satu-Fasa

Jurnal Elkomika
ABSTRAK Modifikasi motor induksi rotor sangkar satu-fasa (MI) menjadi generator magnet permanen satu-fasa (GMP) memberi manfaat seperti re-use MI bekas serta aplikasinya untuk memanen potensi energi hidro sungai kecil berelevasi rendah.
I MADE WIWIT KASTAWAN, RAHMAT HIDAYAT
doaj   +1 more source

GOOD HYGIENE PRACTICES AS AN IMPORTANT PROGRAM FOR SAFETY OF FINAL PRODUCTS

Food and Environment Safety, 2021
In order to meet the requirements regarding food safety, in addition to the HACCP system, food operators are required to adopt, implement and document Good Hygiene Practice (GMP), Good Manufacturing Practice (GMP), Standard Operating Procedures (SOP) and
Ljubica TRAJKOSKA, Maja TRAJANOSKA, Biljana TRAJKOVSKA, Ljupche KOCHOSKI, Vesna KARAPETKOVA-HRISTOVA   +4 more
doaj  

Exosomes From Human Cardiac Progenitor Cells for Therapeutic Applications: Development of a GMP-Grade Manufacturing Method

Frontiers in Physiology, 2018
Exosomes, nanosized membrane vesicles secreted by cardiac progenitor cells (Exo-CPC), inhibit cardiomyocyte apoptosis under stress conditions, promote angiogenesis in vitro, and prevent the early decline in cardiac function after myocardial infarction in
G. Andriolo, Elena Provasi, Viviana Lo Cicero, A. Brambilla, Sabrina Soncin, T. Torre, G. Milano, V. Biemmi, G. Vassalli, L. Turchetto, L. Barile, M. Radrizzani   +11 more
semanticscholar   +1 more source

DataSheet_1_Intranasal Immunization With a c-di-GMP-Adjuvanted Acellular Pertussis Vaccine Provides Superior Immunity Against Bordetella pertussis in a Mouse Model.pdf

, 2022
Pertussis, caused by the gram-negative bacterium Bordetella pertussis, is a highly contagious respiratory disease. Intranasal vaccination is an ideal strategy to prevent pertussis, as the nasal mucosa represents the first-line barrier to B.
Yuhao Su (12409693), Mingbo Sun (6437429), Jiangli Liang (10741002), Wenwen Jiang (1758571), Qin Gu (499256), Li Shi (174141), Lukui Cai (11602006), Xiaoyu Wang (182979), Jingyan Li (1955116)   +8 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

GD2: hopes and challenges for the treatment of pediatric patients with tumors of the central nervous system

npj Precision Oncology
Pediatric Central Nervous System (CNS) tumors are the leading cause of cancer-related death in children, yet effective treatment options remain limited.
Alba Clara Fernández-Rilo, Emmanuel de Billy, Giada Del Baldo, Biagio De Angelis, Sabrina Rossi, Francesca Del Bufalo, Concetta Quintarelli, Franco Locatelli, Angela Mastronuzzi, Maria Vinci   +9 more
doaj   +1 more source