Results 51 to 60 of about 101,384 (314)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

GD2: hopes and challenges for the treatment of pediatric patients with tumors of the central nervous system

open access: yesnpj Precision Oncology
Pediatric Central Nervous System (CNS) tumors are the leading cause of cancer-related death in children, yet effective treatment options remain limited.
Alba Clara Fernández-Rilo   +9 more
doaj   +1 more source

Structural biology of bacterial response regulator proteins and their complexes with cognate ligands [PDF]

open access: yes, 2009
Two bacterial response regulator systems were studied in this thesis. NMR spectroscopy and X-ray crystallography were used to determine the structures of both domains of the antibiotic sensor TipAL, as well as of the c-di-GMP receptor PA4608, in ...
Allan, Martin Georg
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Simulation: A Powerful Tool for Training Professional Skills in Cleanrooms

open access: yesPharmaceutical Technology in Hospital Pharmacy, 2016
This study presents the conception of a simulator for training and evaluating workers that are going to enter and operate in a cleanroom. First, this article explains the pedagogical engineering process developed in order to conceive this pedagogical ...
Denami Maria
doaj   +1 more source

IMPLEMENTASI GMP BERDASAR PADA ISO/TS 22002-1 TERHADAP PRODUKSI IKAN TERI NASI (Stolepherus sp.) DI PT MARINAL INDOPRIMA

open access: yesAgrointek, 2021
ISO / TS 22002-1 is an excellent document to use as a requirement program in the application of a food safety management system for any food producer or processor. This guideline can be applied at PT.
Sri Handayani   +2 more
doaj   +1 more source

The rate and variability of curli induction for the wild-type and for the c-di-GMP-regulation disabled strain.

open access: yes, 2023
(A) Median curli expression, (B) production rate, and (C) number of cells for traces from both microfluidics experiments (r1 and r2) aligned by the time at which they exceeded a threshold of 103 fluorescence units.
Victor Sourjik (195604)   +9 more
core   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

IMPLEMENTASI ASPEK GMP, SSOP, DAN SISTEM HACCP PADA UMKM ONCOM DAWUAN

open access: yesAgrointek, 2021
Dawuan is a sub-district in Subang Regency, West Java, which is famous for its special food, Oncom. Oncom is one of the typical foods from Java which is a fermented product from the substrate of peanut meal or tofu pulp which has been inoculated with red
Rita Purwasih
doaj   +1 more source

The regulation of alginate biosynthesis via cyclic di-GMP signaling

open access: yes, 2020
Bacterial alginates are anionic exopolysaccharides, which are produced by Pseudomonas and Azotobacter species. Bacterial cells embedded in extracellular polymeric substances such as alginates have a survival advantage as they are protected against ...
Rehm, BHA, Moradali, MF
core   +1 more source

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