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Current Approaches to the Abnormal Toxicity Test

Регуляторные исследования и экспертиза лекарственных средств, 2020
For over 60 years, the Abnormal Toxicity Test (ATT) has been used as an important tool in safety control of some parenteral and veterinary products made from biological materials.
N. P. Neugodova, E. O. Stepanyuk, G. A. Sapozhnikova, E. I. Sakanyan, M. S. Ryabtseva   +4 more
doaj   +1 more source

HUBUNGAN SIKAP PENJAMAH MAKANAN DENGAN CARA PRODUKSI PANGAN YANG BAIK PADA INDUSTRI RUMAH TANGGA PANGAN DI KAMPUNG KUE SURABAYA
[Correlation of Food Handlers Attitude with Good Manufacturing Practice in the Household Food Industry in Kampung Kue Surabaya]

Media Gizi Indonesia, 2019
The application of Good Manufacturing Practice (GMP) can improve quality of products. Good manufacturing practice aim to make a safe product to be consumed. Attitude of food handlers can affect practice of food handlers on production process. The purpose
Maya Amelia, Annis Adi
doaj   +1 more source

To be GMP or not to be– a radionuclide’s question

EJNMMI Radiopharmacy and Chemistry
Radionuclides are the essential component of radiopharmaceuticals, their production needs to consider pharmaceutical regulations and guidelines, also for clinical research applications.In this paper we reflect on the pharmaceutical regulatory landscape for radionuclide production in Europe, with a focus on Good Manufacturing Practices (GMP).
Clemens Decristoforo, Renata Mikolajczak, Clive Naidoo, Suzanne Lapi, Ferid Haddad, David Emmanuel Schmid, Lurdes Gano, Ulli Köster, Thierry Stora   +8 more
openaire   +4 more sources

A c-di-GMP signaling module controls responses to iron in Pseudomonas aeruginosa

Nature Communications
Cyclic dimeric guanosine monophosphate (c-di-GMP) serves as a bacterial second messenger that modulates various processes including biofilm formation, motility, and host-microbe symbiosis.
Xueliang Zhan, Kuo Zhang, Chenchen Wang, Qiao Fan, Xiu-Shan Tang, Xi Zhang, Ke Wang, Yang Fu, Haihua Liang   +8 more
semanticscholar   +1 more source

A Hybrid Model of Integrating Sentiment Analysis and Key Market Indicators for IPO Listing Trend Prediction [PDF]

International Journal of Mathematical, Engineering and Management Sciences
Initial Public Offerings (IPOs) provide great opportunities for companies to grow and expand, and they allow investors to invest their money wisely to get a decent Return on Investment (ROI) in the short term.
Ashish Garg, Kamal Kumar Ghanshala, Sachin Sharma   +2 more
doaj   +1 more source

MicroRNAs affecting the susceptibility of melanoma cells to CD8+ T cell‐mediated cytolysis

Clinical and Translational Medicine, 2023
Background The regulatory functions of microRNAs (miRNAs) in anti‐tumour immunity have been mainly described in immune effector cells. Since little is known about miRNA effects on the susceptibility of target cells during T cell—target cell interaction ...
Antonino A. Pane, Theresa Kordaß, Agnes Hotz‐Wagenblatt, Elke Dickes, Annette Kopp‐Schneider, Rainer Will, Barbara Seliger, Wolfram Osen, Stefan B. Eichmüller   +8 more
doaj   +1 more source

Inner-gMP and gMP-inner inverses

Hacettepe Journal of Mathematics and Statistics
Solving some systems of operator equations, new kinds of generalized inverses are introduced. Since these new inverses can be expressed by inner and gMP inverses, they are called inner-gMP and gMP-inner inverses. In this way, the concepts of gMP, 1MP and MP1 inverses are generalized.
Dunja Stojanovic, Dijana Mosic
openaire   +2 more sources

The exopolysaccharide gene cluster Bcam1330-Bcam1341 is involved in Burkholderia cenocepacia biofilm formation, and its expression is regulated by c-di-GMP and Bcam1349 [PDF]

, 2013
In Burkholderia cenocepacia, the second messenger cyclic diguanosine monophosphate (c-di-GMP) has previously been shown to positively regulate biofilm formation and the expression of cellulose and type-I fimbriae genes through binding to the ...
Ryan, Robert P, Givskov, Michael, Fazli, Mustafa, Tolker-Nielsen, Tim, McCarthy, Yvonne   +4 more
core   +1 more source

STING is a direct innate immune sensor of cyclic-di-GMP

Nature, 2011
The innate immune system detects infection by using germline-encoded receptors that are specific for conserved microbial molecules. The recognition of microbial ligands leads to the production of cytokines, such as type I interferons (IFNs), that are ...
Dara L. Burdette, K. Monroe, Katia Sotelo-Troha, J. Iwig, B. Eckert, M. Hyodo, Y. Hayakawa, Russell E. Vance   +7 more
semanticscholar   +1 more source

Structural biology of bacterial response regulator proteins and their complexes with cognate ligands [PDF]

, 2009
Two bacterial response regulator systems were studied in this thesis. NMR spectroscopy and X-ray crystallography were used to determine the structures of both domains of the antibiotic sensor TipAL, as well as of the c-di-GMP receptor PA4608, in ...
Allan, Martin Georg
core   +1 more source