Results 21 to 30 of about 101,384 (314)

A PROPOSAL OF PROCESS VALIDATION IN THE IMPLEMENTATION OF GOOD MANUFACTURING PRACTICES IN BRACHYTHERAPY SOURCES PRODUCTION

open access: yesBrazilian Journal of Radiation Sciences, 2021
New laboratories for brachytherapy sources production are being implemented in our facility at IPEN, in São Paulo. A great challenge implementing a production laboratory is to comply with the Good Manufacturing Practices (GMPs), which involves process ...
Tatyana Spinosa Baptista   +5 more
doaj   +1 more source

Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking [PDF]

open access: yes, 2016
Histidine kinases are key components of regulatory networks in bacteria. Although many of these enzymes are bifunctional, mediating both phosphorylation and dephosphorylation of downstream targets, the molecular details of this central regulatory switch ...
Fucile, Geoffrey   +6 more
core   +1 more source

Preliminary Study on Effect of Chemical Composition Alteration on Elastic Recovery and Stress Recovery of Nitrile Gloves

open access: yesMATEC Web of Conferences, 2018
Nitrile gloves are widely used in the medical and automobile field due to its superiority in hypo-allergic component and chemical resistance over natural latex gloves.
Tan Kai Yang   +6 more
doaj   +1 more source

Food Safety Programs that should be Implemented in Slaughterhouses: Review [PDF]

open access: yesJournal of Applied Veterinary Sciences, 2023
Fresh meat and poultry meat are easily contaminated with various contaminants especially if it is not properly handled and preserved, leading to loss of quality and potential public health problems.Food safety addresses the accidental contamination of ...
Ahmed Ahmed, Omar Al-Mahmood
doaj   +1 more source

Principles of c-di-GMP signaling : characterization of a second messenger system orchestrating bacterial life style [PDF]

open access: yes, 2007
Bacteria are able to switch between two mutually exclusive lifestyles, motile single cells and sedentary multicellular communities, known as biofilms, that colonize surfaces.
Christen, Beat
core   +1 more source

Mechanisms of cyclic-di-GMP signaling : insight into the biochemistry, signal transduction and regulation of the bacterial second messenger cyclic-di-GMP [PDF]

open access: yes, 2007
Bacteria are able to switch between two mutually exclusive lifestyles, motile single cells and sedentary multicellular communities that colonize surfaces.
Christen, Matthias
core   +1 more source

PCR-based analytics of gene therapies using adeno-associated virus vectors: Considerations for cGMP method development

open access: yesMolecular Therapy: Methods & Clinical Development, 2023
The field of gene therapy has evolved and improved so that today the treatment of thousands of genetic diseases is now possible. An integral aspect of the drug development process is generating analytical methods to be used throughout clinical and ...
Emmanuel Blay   +2 more
doaj   +1 more source

Insights into the activation mechanism of PopA, a cyclic di-GMP effector protein involved in cell cycle and development of "Caulobacter Crescentus" [PDF]

open access: yes, 2012
In Caulobacter crescentus, a complex network integrating cyclic di-GMP and Phosphorylation-dependent signals controls the proteolysis of key regulatory proteins to drive cell cycle and polar morphogenesis.
Schalch-Moser, Annina Larissa
core   +1 more source

Folding of the transcription factor Brinker and interactions of the bacterial second messenger c-di-GMP studied by NMR [PDF]

open access: yes, 2013
Nuclear magnetic resonance (NMR) spectroscopy is a technique, which allows the non-invasive investigation of structures, dynamics and interactions of biomolecules.
Gentner, Martin
core   +1 more source

Differences in Expansion Potential of Naive Chimeric Antigen Receptor T Cells from Healthy Donors and Untreated Chronic Lymphocytic Leukemia Patients

open access: yesFrontiers in Immunology, 2018
IntroductionTherapy with chimeric antigen receptor T (CART) cells for hematological malignancies has shown promising results. Effectiveness of CART cells may depend on the ratio of naive (TN) vs.
Jean-Marc Hoffmann   +21 more
doaj   +1 more source

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