Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
Science, 2012 DNA Sensing Is a (c)GAS DNA is normally localized to the nucleus, and so its cytoplasmic localization sends off alarm bells to the immune system because it indicates that a virus may have entered.
Lijun Sun +4 more
semanticscholar +1 more source
Bi-modal distribution of the second messenger c-di-GMP controls cell fate and asymmetry during the caulobacter cell cycle [PDF]
, 2013 Many bacteria mediate important life-style decisions by varying levels of the second messenger c-di-GMP. Behavioral transitions result from the coordination of complex cellular processes such as motility, surface adherence or the production of virulence ...
Abel, Sören +27 more
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Molecular Therapy: Methods & Clinical Development, 2023 The field of gene therapy has evolved and improved so that today the treatment of thousands of genetic diseases is now possible. An integral aspect of the drug development process is generating analytical methods to be used throughout clinical and ...
Emmanuel Blay +2 more
doaj +1 more source
Analysis of cyclic di-GMP signaling components in "caulobacter crescentus" behavior and cell cycle control [PDF]
, 2013 Cell cycle progression and polar morphogenesis in Caulobacter crescentus are coordinated by the interplay of multiple proteins in time and space. One major regulatory factor is the second messenger cyclic di-GMP (c-di-GMP) therefore especially the ...
Friedrich, Elvira
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AgriHealth, 2021 Tempeh had been recognized worldwide as a superfood. In Pengkok Village, Kedawung Sub-district, Sragen Regency, there were several traditional tempeh producers which supply fresh tempeh around Kedawung Sub-district.
Dwi Ishartani +4 more
doaj +1 more source
Novel cyclic di-GMP effectors of the YajQ protein family control bacterial virulence [PDF]
, 2014 Bis-(3',5') cyclic di-guanylate (cyclic di-GMP) is a key bacterial second messenger that is implicated in the regulation of many critical processes that include motility, biofilm formation and virulence. Cyclic di-GMP influences diverse functions through
Caly, Delphine L. +32 more
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Procesul de producție al produselor farmaceutice veterinare - Crida Pharm [PDF]
Medicamentul Veterinar, 2022 The presentation is a description of CridaPharm, a leading Romanian company where the latest achievements in compliance with European regulations, GMP, and ISO 9001-015 are presented. The stages of the manufacturing process in the six production sections
Gabriel Badic
doaj
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP
Nature, 2019 Infections by pathogens that contain DNA trigger the production of type-I interferons and inflammatory cytokines through cyclic GMP–AMP synthase, which produces 2′3′-cyclic GMP–AMP (cGAMP) that binds to and activates stimulator of interferon genes (STING;
G. Shang +4 more
semanticscholar +1 more source
Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator [PDF]
, 2014 Diguanylate cyclases (DGC) and phosphodiesterases (PDE) respectively synthesise and hydrolyse the secondary messenger cyclic dimeric GMP (c-di-GMP), and both activities are often found in a single protein.
Mikolajek, Halina +5 more
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Principles of c-di-GMP signaling : characterization of a second messenger system orchestrating bacterial life style [PDF]
, 2007 Bacteria are able to switch between two mutually exclusive lifestyles, motile single cells and sedentary multicellular communities, known as biofilms, that colonize surfaces.
Christen, Beat
core +1 more source