Results 31 to 40 of about 157,757 (356)

Differences in Expansion Potential of Naive Chimeric Antigen Receptor T Cells from Healthy Donors and Untreated Chronic Lymphocytic Leukemia Patients

open access: yesFrontiers in Immunology, 2018
IntroductionTherapy with chimeric antigen receptor T (CART) cells for hematological malignancies has shown promising results. Effectiveness of CART cells may depend on the ratio of naive (TN) vs.
Jean-Marc Hoffmann   +21 more
doaj   +1 more source

Local c-di-GMP Signaling in the Control of Synthesis of the E. coli Biofilm Exopolysaccharide pEtN-Cellulose

open access: yesJournal of Molecular Biology, 2020
In many bacteria, the biofilm-promoting second messenger c-di-GMP is produced and degraded by multiple diguanylate cyclases (DGC) and phosphodiesterases (PDE), respectively. High target specificity of some of these enzymes has led to theoretical concepts
A. M. Richter   +6 more
semanticscholar   +1 more source

Activation and polar sequestration of PopA, a c-di-GMP effector protein involved in Caulobacter crescentus cell cycle control [PDF]

open access: yes, 2014
When Caulobacter crescentus enters S-phase the replication initiation inhibitor CtrA dynamically positions to the old cell pole to be degraded by the polar ClpXP protease.
Ebbensgaard, Anna Elisabeth   +7 more
core   +1 more source

Table_2_Genome characterization of a uropathogenic Pseudomonas aeruginosa isolate PA_HN002 with cyclic di-GMP-dependent hyper-biofilm production.xlsx

open access: yes, 2022
Pseudomonas aeruginosa can cause various types of infections and is one of the most ubiquitous antibiotic-resistant pathogens found in healthcare settings.
Ting Li (117885)   +8 more
core   +1 more source

DataSheet_1_Genome characterization of a uropathogenic Pseudomonas aeruginosa isolate PA_HN002 with cyclic di-GMP-dependent hyper-biofilm production.pdf

open access: yes, 2022
Pseudomonas aeruginosa can cause various types of infections and is one of the most ubiquitous antibiotic-resistant pathogens found in healthcare settings.
Ting Li (117885)   +8 more
core   +1 more source

Low cost and open source purification apparatus for GMP [13N]ammonia production [PDF]

open access: yes, 2021
Nitrogen-13 labeled ammonia ([13N]NH3) has been used for myocardial perfusion imaging with Positron Emission Tomography for decades. Recent increases to regulatory oversight have led to stricter adherence Good Manufacturing Practice (GMP) to produce this
Farah, Kamar   +2 more
core   +1 more source

Controlling the Immune Suppressor: Transcription Factors and MicroRNAs Regulating CD73/NT5E

open access: yesFrontiers in Immunology, 2018
The NT5E (CD73) molecule represents an ecto-5′-nucleotidase expressed on the cell surface of various cell types. Hydrolyzing extracellular adenosine monophosphate into adenosine and inorganic phosphate, NT5E performs numerous homeostatic functions in ...
Theresa Kordaß   +3 more
doaj   +1 more source

Cyclic-GMP-AMP Is An Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

open access: yesScience, 2012
DNA Sensing Is a (c)GAS DNA is normally localized to the nucleus, and so its cytoplasmic localization sends off alarm bells to the immune system because it indicates that a virus may have entered.
Jiaxi Wu   +6 more
semanticscholar   +1 more source

Analysis of the c-di-GMP mediated cell fate determination in Caulobacter crescentus [PDF]

open access: yes, 2009
Cyclic-di-GMP (c-di-GMP) is a ubiquitous second messenger in bacteria, which has been recognized as a key regulator, antagonistically controlling the transition between motile, planktonic cells and surface attached, multicellular communities.
Abel, Sören
core   +1 more source

Table_1_Phenotypic and integrated analysis of a comprehensive Pseudomonas aeruginosa PAO1 library of mutants lacking cyclic-di-GMP-related genes.docx

open access: yes, 2022
Pseudomonas aeruginosa is a Gram-negative bacterium that is able to survive and adapt in a multitude of niches as well as thrive within many different hosts. This versatility lies within its large genome of ca. 6 Mbp and a tight control in the expression
Joey Kuok Hoong Yam (6295388)   +9 more
core   +1 more source

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