Results 71 to 80 of about 4,568 (194)

Establishment and Characterization of MCA23, a Novel Mouse Intrahepatic Cholangiocarcinoma Cell Line

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Introduction Intrahepatic cholangiocarcinoma (ICC) is an aggressive type of malignancy. Recent advancements have highlighted the importance of the tumor immune microenvironment in therapeutic responses and prognosis. However, the lack of a mouse‐derived ICC cell line and current mouse models limit explorations of the TME in ICC.
Yuchao He, Yi Luo, Liwei Chen, Yu Wang, Bei Liu, Mengting Sun, Wenchen Gong, Xiangdong Tian, Lin Guo, Qin Zhang, Qiang Wu, Lu Chen, Hua Guo   +12 more
wiley   +1 more source

Lactylation in colorectal cancer: Unveiling novel mechanisms in metabolism, progression and therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Lactate accumulation links metabolic reprogramming to epigenetic regulation via protein lactylation. Lactylation drives colorectal cancer proliferation, metastasis, immune escape and chemoresistance. Microbiota‐derived lactate shapes a tumour‐specific lactylation landscape in colorectal cancer.
Ming Liu, Weiwei Li, Yi Ji, Yanqing Chen, Guoli Wei, Jiege Huo, Tao Gui   +6 more
wiley   +1 more source

Myasthenia Gravis With Acetylcholine Receptor Antibodies in the Very Old: Treatment Challenges and Diagnostic Pitfalls

European Journal of Neurology, Volume 33, Issue 2, February 2026.
Myasthenia gravis in the very old and with debut after age 65 years increases in incidence and prevalence. Early, active symptomatic and immunosuppressive treatment is needed with the aim of obtaining pharmacological remission or minimal manifestations only. Myasthenic crisis with respiratory failure remains a threat.
Nils Erik Gilhus
wiley   +1 more source

Multidimensional analyses of the pathomechanism caused by the non-catalytic GNE variant, c.620A>T, in patients with GNE myopathy [PDF]

, 2022
Wakako Yoshioka, Aritoshi Iida, Kyuto Sonehara, Kazuki Yamamoto, Yasushi Oya, Madoka Mori‐Yoshimura, Takashi Kurashige, Mariko Okubo, Megumu Ogawa, Fumihiko Matsuda, Koichiro Higasa, Shinichiro Hayashi, Harumasa Nakamura, Masakazu Sekijima, Yukinori Okada, S. Noguchi, Ichizo Nishino   +16 more
openalex   +1 more source

Temporomandibular disorders and neck disability in individuals with cervical disc herniation

European Journal of Oral Sciences, Volume 134, Issue 1, February 2026.
Abstract The primary aim of this study was to investigate the prevalence and severity of temporomandibular disorders (TMDs), and temporomandibular joint (TMJ) pain in patients with cervical disc herniation. The secondary aim was to investigate the relationship between neck disability, neck pain, sociodemographic factors, TMD, and TMJ pain.
Turgay Altunalan, Esin Geçgil Nazli, İlayda Gür, Nurhayat Korkmaz Üçüncü   +3 more
wiley   +1 more source

Pregnancy in GNE myopathy patients: a nationwide repository survey in Japan

Orphanet Journal of Rare Diseases, 2020
Background GNE myopathy is an autosomal recessive adult-onset distal myopathy. While a few case reports have described the progression of GNE myopathy during pregnancy, to our knowledge, none have examined disease progression after delivery or obstetric ...
Wakako Yoshioka, Naoyuki Miyasaka, Ryo Okubo, Reiko Shimizu, Yuji Takahashi, Yuriko Oda, Ichizo Nishino, Harumasa Nakamura, Madoka Mori-Yoshimura   +8 more
doaj   +1 more source

Integrative Analysis of Cytotoxic Lymphocytes‐Mediated Tumour Killing Related Genes Reveals LDHA as a Novel Glioblastoma Therapeutic Target

Journal of Cellular and Molecular Medicine, Volume 30, Issue 4, February 2026.
ABSTRACT Glioblastoma (GBM) features profound immunosuppression and metabolic reprogramming that undermine immunotherapy. We sought biomarkers that capture cytotoxic lymphocyte activity and nominate tractable targets. Using TCGA, we quantified NK/CD8+ T‐cell infiltration (CIBERSORTx), identified differentially expressed genes and derived a three‐gene ...
Shaojie Yu, Xudong Li, Ji Wu, Minjie Wang, Zihan Gong, Baowen Zhang, Haojun Shi, Xuan Wang, Wei Xiang   +8 more
wiley   +1 more source

An inexact-penalty method for GNE seeking in games with dynamic agents [PDF]

, 2021
Andrew R. Romano, Lacra Pavel
openalex   +1 more source

Epigenetic reprogramming in multiple myeloma—Challenges and opportunities

International Journal of Cancer, Volume 158, Issue 2, Page 423-432, 15 January 2026.
Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar, Lev M. Kats, Emily Gruber   +2 more
wiley   +1 more source

Reassessing Electrolyte Design for Non‐Aqueous Magnesium Batteries: Atomistic Structures and Performance Optimization

Advanced Materials, Volume 38, Issue 5, 22 January 2026.
This review systematically examines recent advances in non‐aqueous electrolytes for rechargeable magnesium batteries, focusing on chlorine‐containing and chlorine‐free systems. It highlights the interdependent relationship between electrolyte compositions, atomistic structures, and electrochemical performance.
Hao Xu, Xiaoqian He, Yue Li, Quanquan Guo, Xinyu Sun, Xinlong Xie, Lingyue Liu, Richard M. Laine, Jianxin Zou, Xinliang Feng, Minghao Yu   +10 more
wiley   +1 more source