Results 81 to 90 of about 4,568 (194)

The BET PROTAC inhibitor GNE-987 displays anti-tumor effects by targeting super-enhancers regulated gene in osteosarcoma

BMC Cancer
Background Osteosarcoma (OS) is one of the most common primary malignant tumors of bone in children, which develops from osteoblasts and typically occurs during the rapid growth phase of the bone.
Di Wu, Hongli Yin, Chun Yang, Zimu Zhang, Fang Fang, Jianwei Wang, Xiaolu Li, Yi Xie, Xiaohan Hu, Ran Zhuo, Yanling Chen, Juanjuan Yu, Tiandan Li, Gen Li, Jian Pan   +14 more
doaj   +1 more source

Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Overview of Sructure, Multienzyme‐mimicking Activity and Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase. Abstract Redox dysregulation is recognized as a key driver in the pathophysiology of numerous refractory diseases, contributing significantly to the progression and poor prognosis.
Kai Song, Yu Wei, Peng Jia, Shan He, Qian Wang, Manman Xu, Hongzhi Liu, Pengtao Bao, Shanyue Guan, Xiaozhong Qu   +9 more
wiley   +1 more source

Estimation of the Internal Temperature of High-Capacity Li-Ion Cells Using Embedded Impedancemetry

IEEE Open Journal of Vehicular Technology
The internal temperature of electrochemical accumulators is a crucial parameter that significantly impacts their aging and safety. In particular, the phenomenon of thermal runaway must be detected early due to its rapid progression and potentially ...
Charles Bechara, Guy Friedrich, Christophe Forgez, Samuel Cregut   +3 more
doaj   +1 more source

Safety and efficacy of N-acetylmannosamine (ManNAc) in patients with GNE myopathy: an open-label phase 2 study

, 2021
Nuria Carrillo, May Christine V. Malicdan, Petcharat Leoyklang, Joseph A. Shrader, Galen O. Joe, Christina Slota, John Perreault, John D. Heiss, Bradley Class, Chia‐Ying Liu, Kennan Bradley, Colleen Jodarski, Carla Ciccone, Claire T. Driscoll, Rebecca Parks, Scott Van Wart, Levent Bayman, Christopher S. Coffey, Melanie Quintana, Scott Berry, Marjan Huizing, William A. Gahl   +21 more
openalex   +1 more source

Identification of biomarkers for GNE myopathy

The FASEB Journal, 2012
GNE‐myopathy is an autosomal recessive disorder characterized by muscle atrophy and weakness, and accumulation of amyloid proteins and rimmed vacuoles in myofibers. This disease is secondary to mutations in the GNE gene, which encodes an essential enzyme in sialic acid biosynthesis. Recently,
May Christine Malicdan, Kazunari Momma, Ichizo Nishino, Satoru Noguchi   +3 more
openaire   +1 more source

Supplementation of Nicotinic Acid with NAMPT Inhibitors Results in Loss of In Vivo Efficacy in NAPRT1-Deficient Tumor Models

Neoplasia: An International Journal for Oncology Research, 2013
Nicotinamide adenine dinucleotide (NAD) is a metabolite essential for cell survival and generated de novo from tryptophan or recycled from nicotinamide (NAM) through the nicotinamide phosphoribosyltransferase (NAMPT)-dependent salvage pathway ...
Thomas O'Brien, Jason Oeh, Yang Xiao, Xiaorong Liang, Alexander Vanderbilt, Ann Qin, Lulu Yang, Leslie B. Lee, Justin Ly, Ely Cosino, Jennifer A. LaCap, Annie Ogasawara, Simon Williams, Michelle Nannini, Bianca M. Liederer, Peter Jackson, Peter S. Dragovich, Deepak Sampath   +17 more
doaj   +1 more source

miR-550a-5p promotes the proliferation and migration of hepatocellular carcinoma by targeting GNE via the Wnt/β-catenin signaling pathway

, 2022
Chunming Li, Wu Wu, Zhu Zhu, Pei-Lin Lu, Jianping Gong, Rong Ma   +5 more
openalex   +2 more sources

Distributed GNE Seeking Under Partial-Decision Information Over Networks via a Doubly-Augmented Operator Splitting Approach [PDF]

, 2019
Lacra Pavel
openalex   +1 more source

578. Manufacturing and Stability Testing of a GNE-Lipoplex for a Clinical Trial for the Treatment of Hereditary Inclusion Body Myopathy Type (HIBM) [PDF]

, 2010

openalex   +1 more source

GNE миопатия: проспективно клинично проучване на прогресията на мускулната слаБост и серумните нива на креатинкиназа

Българска неврология, 2021
GNE миопатия е наследствено невромускулно заболяване, което протича с прогресираща слабост в дисталните отдели на долни крайници, а в последствие ангажира и проксималните мускули на ръцете и краката и води до загуба на самостоятелната походка.
Kristina Kastreva, T. Chamova, K. Chobanov, T. Dimitrova, I. Tournev   +4 more
doaj