Results 121 to 130 of about 3,060 (210)

Cre/lox generation of a novel whole-body Kiss1r KO mouse line recapitulates a hypogonadal, obese, and metabolically-impaired phenotype. [PDF]

, 2019
Kisspeptin and its receptor, Kiss1r, act centrally to stimulate reproduction. Recent evidence indicates that kisspeptin is also important for body weight and metabolism, as whole-body Kiss1r KO mice, developed with gene trap technology, display obesity ...
Kauffman, Alexander S, Marooki, Nuha, Smith, Jeremy T, Tolson, Kristen P, Wolfe, Andrew   +4 more
core   +1 more source

Early menopause: A hazard to a woman's health [PDF]

, 2017
Early menopause or premature ovarian insufficiency (POI) is a common cause of infertility in women and affects about one per cent of young women. This disorder has significant psychological sequelae and major health implications.
Castelo-Branco Flores, Camil, Hernández Angeles, Claudio   +1 more
core   +1 more source

A simple integrative electrophysiological model of bursting GnRH neurons [PDF]

, 2012
In this paper a modular model of the GnRH neuron is presented. For the aim of simplicity, the currents corresponding to fast time scales and action potential generation are described by an impulsive system, while the slower currents and calcium dynamics ...
Csercsik, Dávid, Farkas, Imre, Hrabovszky, Erik, Liposits, Zsolt   +3 more
core   +1 more source

POMC neurons control fertility through differential signaling of MC4R in kisspeptin neurons

eLife
Inactivating mutations in the melanocortin 4 receptor (MC4R) gene cause monogenic obesity. Interestingly, female patients also display various degrees of reproductive disorders, in line with the subfertile phenotype of Mc4r KO female mice.
Rajae Talbi, Todd L Stincic, Kaitlin Ferrari, Choi Ji Hae, Karol Walec, Elizabeth Medve, Achi Gerutshang, Silvia Leon, Elizabeth A McCarthy, Oline K Rønnekleiv, Martin J Kelly, Victor M Navarro   +11 more
doaj   +1 more source

Electrophysiological Recording of Hypothalamic GnRH Pulse Generator Activity in Castrated Male Goats.

Journal of Reproduction and Development, 1995
Electrophysiological recording of the hypothalamic GnRH pulse generator activity was attempted in 3 long-term castrated male goats in which electrodes had been implanted in the medial basal hypothalamus (MBH). While multiple unit activity (MUA) signals from the electrode were continuously recorded, each animal received subcutaneous implants containing ...
Yukio KANAI, Junko YAMASAKI, Yukari TAKEUCHI, Nobuyo KOIKE, Mayumi FUJIYAMA, Yuji MORI   +5 more
openaire   +2 more sources

KNDy neurone activation prior to the LH surge of the ewe is disrupted by LPS [PDF]

, 2017
In the ewe, steroid hormones act on the hypothalamic arcuate nucleus (ARC) to initiate the GnRH/LH surge. Within the ARC, steroid signal transduction may be mediated by estrogen receptive dopamine-, β-endorphin- or neuropeptide Y (NPY)-expressing cells ...
Dobson, H, Fergani, C, Jones, DN, Pickavance, LC, Routly, JE, Smith, RF   +5 more
core   +1 more source

Prenatal Testosterone Excess Decreases Neurokinin 3 Receptor Immunoreactivity within the Arcuate Nucleus KNDy Cell Population [PDF]

, 2015
Prenatal exposure of the female ovine foetus to excess testosterone leads to neuroendocrine disruptions in adulthood, as demonstrated by defects in responsiveness with respect to the ability of gonadal steroids to regulate gonadotrophin‐releasing hormone
Almeida, Amstalden, Billings, Caraty, Chawla, Cheng, Cheng, Coolen, Estrada, Fergani, Franceschini, Garcia-Galiano, Gaskins, Glowinski, Goodman, Goodman, Goodman, Gorski, Goubillon, Grachev, Herbosa, Hrabovszky, Hunyady, Jackson, Jackson, Jackson, Karsch, Krajewski, Lehman, Merkley, Mittelman-Smith, Mussap, Navarro, Navarro, Navarro, Oakley, Padmanabhan, Padmanabhan, Pineda, Porter, Ramaswamy, Ramaswamy, Rance, Rance, Rance, Robinson, Sharma, Simerly, Smith, Smith, Topaloglu, Veiga-Lopez, Veiga-Lopez, Veiga-Lopez, Veiga-Lopez, Wakabayashi, Watson, Yan, Young   +58 more
core   +2 more sources

Human prepubertal aromatase deficiency: physiological and pathophysiological lessons learned from this experiment of nature [PDF]

, 2007
En els humans, el cP450arom és el producte d'un gen únic (CYP19), localitzat en el cromosoma 15q21.1. A la placenta, l'aromatització activa dels andrògens protegeix el fetus femella i la mare de les accions virilitzants dels andrògens fetals. De fet, els
Belgorosky, Alicia, Rivarola, Marco A.
core  

Do Substance P and Neurokinin A Play Important Roles in the Control of LH Secretion in Ewes? [PDF]

There is now general agreement that neurokinin B (NKB) acts via neurokinin-3-receptor (NK3R) to stimulate secretion of GnRH and LH in several species, including rats, mice, sheep, and humans.
Coolen, LM, Fergani, C, Goodman, RL, Grachev, P, Hardy, SL, Lehman, MN, Mazzella, L, McCosh, RB, Newcomb, N   +8 more
core   +1 more source

Chemogenetic activation of PVN CRH neurons disrupts the estrous cycle and LH dynamics in female mice

Frontiers in Endocrinology
IntroductionThe impact of stress on reproductive function is significant. Hypothalamic paraventricular nucleus (PVN) corticotrophin-releasing hormone (CRH) plays a major role in regulating the stress response. Understanding how the hypothalamic-pituitary-
Junru Yu, Xiao-Feng Li, Krasimira Tsaneva-Atanasova, Krasimira Tsaneva-Atanasova, Eder Zavala, Kevin T. O’Byrne   +5 more
doaj   +1 more source