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Neurobiological mechanisms underlying GnRH pulse generation by the hypothalamus
Brain Research, 2010Gonadotropin-releasing hormone (GnRH) secretion has two modes of release in mammalian species; the surge mode and the pulse mode. The surge mode, which is required for the induction of the preovulatory gonadotropin discharge in most species, is induced by the positive feedback of estrogen secreted by the mature ovarian follicle.
Kei-Ichiro, Maeda +6 more
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Neuroendocrinology, 2008
The pulsatile secretion of luteinizing hormone (LH), occasioned by the pulsatile release of gonadotropin-releasing hormone (GnRH), is closely associated with concurrent increases in multiunit electrical activity in the mediobasal hypothalamus (MUA volleys), the electrophysiological correlates of GnRH pulse generator activity.
T, Ordög +5 more
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The pulsatile secretion of luteinizing hormone (LH), occasioned by the pulsatile release of gonadotropin-releasing hormone (GnRH), is closely associated with concurrent increases in multiunit electrical activity in the mediobasal hypothalamus (MUA volleys), the electrophysiological correlates of GnRH pulse generator activity.
T, Ordög +5 more
openaire +2 more sources
Electrophysiological Analysis of GnRH Pulse Generator Activity in the Rhesus Monkey
1994Publisher Summary Many strategies have been used to monitor gonadotropin-releasing hormone (GnRH) pulse generator activity, in addition to the detection of luteinizing-hormone pulses in the peripheral blood. These have included the measurement of GnRH pulses in pituitary portal blood.
Kevin T. O'Byrne, Ernst Knobil
openaire +1 more source
Origins of the ‘KNDy hypothesis’ of GnRH pulse generation
Nature Reviews Endocrinology, 2022openaire +2 more sources
In Vivo Electrophysiological Monitoring of the GnRH Pulse Generator in Rats and Goats
1994Publisher Summary This chapter presents a procedure that has permitted permanent recording of electrophysiological manifestation of gonadotropin-releasing hormone pulse-generator activity in awake, freely behaving rats and goats. All pins of the IC except for those of non-inverse input, which initiate the signal input from the electrodes, are gently ...
Masugi Nishihara +3 more
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New methods to investigate the GnRH pulse generator
Endocrine Abstracts, 2022openaire +1 more source
Uncovering how the GnRH pulse generator is controlled in female mice
Nature Reviews Endocrinology, 2022openaire +2 more sources