Results 131 to 140 of about 829,091 (166)
Foliation-Based Parameter Tuning in a Model of the GnRH Pulse and Surge Generator [PDF]
SIAM Journal on Applied Dynamical Systems, 2009 We investigate a model of the GnRH pulse and surge generator, with the definite aim of constraining the model GnRH output with respect to a physiologically relevant list of specifications. The alternating pulse and surge pattern of secretion results from the interaction between a GnRH secreting system and a regulating system exhibiting fast-slow ...
Alexandre Vidal, Frédérique Clement
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Derangement of the hypothalamic GnRH pulse generator in women with epilepsy
Seizure: the Journal of the British Epilepsy Association, 1993 An increased frequency of reproductive endocrine diseases has been described in women with epilepsy and a subclinical reproductive dysfunction has been suggested in normally menstruating epileptic women. We assessed the reproductive endocrine function in 11 normally menstruating, drug-free epileptic women, evaluating the basal hormonal profile and LH ...
Leonilda Bilo, Salvatore Striano, R Meo
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American Journal of Obstetrics and Gynecology, 1990
The notion of an oscillator or signal generator in the central nervous system that controls the rhythmic release of GnRH and, thereby, the pulsatile secretion of the gonadotropic hormones, originated in the finding of strikingly abrupt and rhythmic fluctuations in the concentration of LH in the plasma of ovariectomized monkeys. These oscillations had a
Ernst Knobil, E Knobil
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The notion of an oscillator or signal generator in the central nervous system that controls the rhythmic release of GnRH and, thereby, the pulsatile secretion of the gonadotropic hormones, originated in the finding of strikingly abrupt and rhythmic fluctuations in the concentration of LH in the plasma of ovariectomized monkeys. These oscillations had a
Ernst Knobil, E Knobil
exaly +3 more sources
The hypothalamic GnRH pulse generator: multiple regulatory mechanisms [PDF]
Trends in Endocrinology and Metabolism, 2009 Pulsatile secretion of gonadotropin-releasing hormone (GnRH) release is an intrinsic property of hypothalamic GnRH neurons. Pulse generation has been attributed to multiple specific mechanisms, including spontaneous electrical activity of GnRH neurons, calcium and cAMP signaling, a GnRH receptor autocrine regulatory component, a GnRH concentration ...
Lazar Z Krsmanović +2 more
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The electrophysiology of the GnRH pulse generator in the rhesus monkey
The Journal of Steroid Biochemistry, 1989The electrophysiological correlates of hypothalamic GnRH pulse generator activity in the rhesus monkey are described. They are characterized by abrupt increases in neuronal multiunit electrical activity (volleys) that are coincident with the initiation of LH pulses in the peripheral circulation.
Ernst Knobil, E Knobil
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Unraveling the Mechanism of Action of the GnRH Pulse Generator
2014Michael N Lehman +2 more
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KNDy Neurons of the Hypothalamus and Their Role in GnRH Pulse Generation: an Update
Endocrinology, 2023Abstract There is considerable evidence that synchronized activity within a reciprocally connected population of cells in the arcuate nucleus (ARC) coexpressing kisspeptin, neurokinin B (NKB), and dynorphin (KNDy cells) is crucial for the generation of gonadotrophin-releasing hormone (GnRH) pulses in mammals. The initial “KNDy hypothesis”
Aleisha M Moore +2 more
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Kisspeptin and GnRH Pulse Generation
2013The reproductive neuropeptide gonadotropin-releasing hormone (GnRH) has two modes of secretion. Besides the surge mode, which induces ovulation in females, the pulse mode of GnRH release is essential to cause various reproductive events in both sexes, such as spermatogenesis, follicular development, and sex steroid synthesis.
Hiroaki, Okamura +5 more
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Unraveling the Neural Mechanisms Underlying the GnRH Pulse Generator: An Update
2021Michael N Lehman +2 more
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