Results 61 to 70 of about 357,265 (161)

The preclinical evaluation of immunocontraceptive vaccines based on canine zona pellucida 3 (cZP3) in a mouse model

Reproductive Biology and Endocrinology, 2018
Background Stray dogs are the reservoirs and carriers of rabies and are definitive hosts of echinococcosis. To control the overpopulation of stray dogs, zona pellucida 3 (ZP3), a primary receptor for sperm, is a potential antigen for developing ...
Ying Wang, Yijie Li, Beibei Zhang, Fuchun Zhang   +3 more
doaj   +1 more source

Effect of the biological castration vaccine (Improvac®) on sex hormones and reproductive organs of pigs in Vietnam

Veterinary Integrative Sciences, 2023
The Improvac® vaccine has been shown to improve growth performance, meat quality, and sexual behavior in swine herds in several countries. This study initially investigated the ability of this vaccine to control sex hormones and the development ...
Danh Cong Lai, Nam Minh Nguyen, Khanh Tran Doan Vinh, Hue Vo Thi, Phong Du Dai, Duy Tien Do   +5 more
doaj   +1 more source

MicroRNAs in Methamphetamine: Addiction, Neurotoxicity, and Therapeutic Potential

MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
The use of METH leads to the release of dopamine from the affected brain regions, including the nucleus accumbens (NAc), ventral tegmental area (VTA), prefrontal cortex (PFC), hippocampus (Hip), and striatum. This triggers signals that alter miRNA expression, which in turn leads to differential expression of target genes.
Yacoubou Abdoul Razak Mahaman, An‐Ping Ye, Ya‐Xian Zhang, Ming‐Yu Chen, Fang Huang, Rong Liu, Ying‐Yan Fang, Xiaochuan Wang   +7 more
wiley   +1 more source

Single dose of SA 14-14-2 vaccine provides long-term protection against Japanese encephalitis: A case-control study in Nepalese children 5 years after immunization

, 2007
In July 1999, a single dose of live-attenuated SA 14-14-2 Japanese encephalitis (JE) vaccine was administered to children living in the Bardiya, Banke and Kailali districts of Nepal.
오희철, 남정모
core   +1 more source

The marginal willingness-to-pay for attributes of a hypothetical HIV vaccine [PDF]

, 2012
This paper estimates the marginal willingness-to-pay for attributes of a hypothetical HIV vaccine using discrete choice modeling. We use primary data from 326 respondents from Bangkok and Chiang Mai, Thailand, in 2008–2009, selected using purposive ...
Newman, Peter A., Newman, PA, P. A. Newman, S. Roungprakhon, Newman, P.A., Cameron, MP, Scarpa, R., Scarpa, R, Scarpa, Riccardo, Roungprakhon, S, Cameron, Michael P., Cameron, Michael Patrick, Cameron, M.P., Roungprakhon, S., Roungprakhon, Surachet, M. P. Cameron   +15 more
core   +1 more source

Influences of Immunocastration on Endocrine Parameters, Growth Performance and Carcass Quality, as Well as on Boar Taint and Penile Injuries

Animals, 2020
Castration of male pigs without anesthesia is a significant welfare issue. Improvac®, a GnRH vaccine induces an endogenous immune response leading to a decrease in testicular steroids.
Susanne Zoels, Simon Reiter, Mathias Ritzmann, Christine Weiß, Jasmin Numberger, Aneka Schütz, Peter Lindner, Volker Stefanski, Ulrike Weiler   +8 more
doaj   +1 more source

Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem, Atif Ali, Wajid Ali, Yuying Cheng, Zhibin Yan, Chaoyi Xia, Chenguang Liu, Caiyun Fu, Yiren Hu, Xi Wang   +9 more
wiley   +1 more source

INSL3 Expression in Leydig Cells is a Biomarker for Immunocastration in Boars: Transcriptional Evidence

Andrology, Volume 14, Issue 3, Page 782-795, March 2026.
ABSTRACT Background Study aimed to obtain insights into physiological responses to immunocastration in pubertal boars by evaluating effects of alternative vaccination protocols and identifying a reliable immunocastration biomarker. Objectives It was hypothesized that the timing of gonadotropin‐releasing hormone (GnRH) suppression by immunocastration ...
Nina Batorek Lukač, Martin Škrlep, Klavdija Poklukar, Petra Ferjan, Volker Stefanski, Gregor Fazarinc, Milka Vrecl   +6 more
wiley   +1 more source

Sex‐Specific Factors Influencing HIV Infection

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Immune responses are key in controlling viral infections such as HIV‐1, which remains a global challenge to public health. X/Y‐chromosome‐encoded genes and sex steroid hormones can modulate immune cells and drive distinct patterns of gene and protein expression involved in antiviral function, impacting sex‐dependent immune responses and ...
Maria Pujantell, Marcus Altfeld
wiley   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source