Extracellular Vesicles: Biology, Intercellular Communication and Therapeutic Potential in Diabetes
Exosome packaging in diabetes mellitus is depicted. Induced expression levels of RBP4, WNT related proteins, TGFB1, BMPs, VEGFs, STAT3, Calpain2 and altered expression levels of microRNAs in the exosomes are responsible for the inflammatory actions, defective central metabolism, myofibroblasts proliferation, dysregulated cell migration, cell ...
Swayam Prakash Srivastava +9 more
wiley +1 more source
Cost-effectiveness analysis of the implementation of a National Immunization Program for rotavirus vaccination in a country with a low rotavirus gastroenteritis-related mortality: A South Korean study [PDF]
Rotavirus is a leading cause of severe gastroenteritis among children younger than 5 years in South Korea. Two rotavirus vaccines (RVs), pentavalent human-bovine reassortant vaccine (Rotateq®; RV5) and attenuated human strain originated monovalent ...
김지홍, 김동수
core +1 more source
Abstract This article presents two clinical cases of bilateral laparoscopic ovariectomy in Dexter heifers used as leisure animals to eliminate problematic sexual behaviour. Initial standing flank laparoscopy in one heifer failed due to anatomical limitations.
Cuevas‐Ramos Gabriel +3 more
wiley +1 more source
Varicella Breakthrough Infection and Vaccine Effectiveness in Taiwan
We performed this nationwide retrospective investigation among the recipients of varicella vaccine to evaluate the breakthrough varicella infection rate, factors associated with breakthrough infection and the vaccine effectiveness.
HUANG, WEN-CHAN;HUANG, LI-MIN;CHANG, I-SHOU;TSAI, FANG-YU;CHANG, LUAN-YIN +1 more
core +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
Breast Cancer: Molecular Pathogenesis, Targeted Therapy, Screening, and Prevention
The review manuscript examines the molecular pathogenesis, screening, prevention advances, and evolving targeted therapies in breast cancer. It highlights the integration of AI and multiomics for precision prevention and personalized treatment, pointing toward future directions in equitable cancer care.
Huijun Lei +7 more
wiley +1 more source
Reproductive and Behavioral Evaluation of a New Immunocastration Dog Vaccine
Canine immunocastration development has been of interest for many years as a complementary strategy to surgical castration. The purpose of this paper was to verify the effect of a recombinant vaccine for dog immunocastration.
Daniela Siel +9 more
doaj +1 more source
Update and new advances in fertility preservation and cancer
Abstract Adolescents and young adults with a cancer diagnosis face unique challenges during treatment and into survivorship related to fertility and family building. This review provides an updated overview of the impact of cancer and its associated treatments, including novel treatments in male and female fertility.
Gwendolyn P. Quinn +11 more
wiley +1 more source
Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies:Physiological, Pathophysiological and Therapeutic Implications [PDF]
Pulsatile gonadotropin-releasing hormone (GnRH) is crucial to normal reproductive function and abnormalities in pulse frequency give rise to reproductive dysfunction.
Young, Jacques +12 more
core +1 more source
A Review of Contemporary Contraceptives and Sterilization Techniques for Feral Horses
This commentary provides a brief review of the history of contraceptive research eff orts for feral horses (Equus ferus caballus) as well as the contraceptives and sterilization techniques currently available for feral horses. Porcine zona pellucida (PZP)
Albert J. Kane
doaj +1 more source

