Results 41 to 50 of about 475,793 (348)

Impaired goal-directed behavioural control in human impulsivity. [PDF]

, 2017
PublishedJournal ArticleResearch Support, Non-U.S. Gov'tThis is the final version of the article. Available from Taylor & Francis (Routledge) via the DOI in this record.Two dissociable learning processes underlie instrumental behaviour.
Baess, K, Chase, HW, Hogarth, L
core   +1 more source

Clinical Course and Impact of Breaks in Therapy for Children With Relapsed/Refractory Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pediatric relapsed or refractory (R/R) solid tumors carry a dismal prognosis, and postrelapse patient experiences are not well described. We present postrelapse outcomes, including number of R/R events and subsequent therapy regimens.
Matthew T. McEvoy, Elizabeth L. Seashore, W. Susan Cheng, Shondra Clay, Jessica A. Casas, Jennifer H. Foster   +5 more
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A multi-center, double-blind, placebo-controlled, randomized, parallel-group, non-inferiority study to compare the efficacy of goal-directed tranexamic acid administration based on viscoelastic test versus preemptive tranexamic acid administration on postoperative bleeding in cardiovascular surgery (GDT trial)

Trials
Background Tranexamic acid (TXA) effectively attenuates hyperfibrinolysis and preemptive administration has been employed to reduce bleeding and blood transfusions in various surgical settings. However, TXA administration could be associated with adverse
Jae-Sik Nam, Chung-Sik Oh, Ji-Yoon Kim, Dae-Kee Choi, Ah Ran Oh, Jungchan Park, Jong-Hwan Lee, Sung-Cheol Yun, Kyeng Whan Kim, Min Uk Jang, Tae-Yop Kim, In-Cheol Choi   +11 more
doaj   +1 more source

Goal Directed Conflict Resolution and Policy Refinement [PDF]

, 2012
Peer ...
Aphale, Mukta Sumeet, Norman, Timothy J, Sensoy, Murat   +2 more
core  

Goal-Directed Treatment for Osteoporosis: A Progress Report from the ASBMR-NOF Working Group on Goal-Directed Treatment for Osteoporosis. [PDF]

, 2017
The American Society for Bone and Mineral Research and the United States National Osteoporosis Foundation (NOF) formed a working group to develop principles of goal-directed treatment and identify gaps that need to be filled to implement this approach ...
Adler, Austin, Black, Black, Black, Black, Boonen, Brown, Center, Clinton, Cosman, Cosman, Cosman, Cosman, Cosman, Crandall, Cummings, Cummings, Diez-Perez, Diez-Perez, Ferrari, Fink, Freemantle, Giangregorio, Hadji, Hochberg, Johnell, Kanis, Kanis, Leder, Leslie, Leslie, Lewiecki, Lewiecki, Lindsay, Marshall, McClung, McClure, Murad, Neuner, Recknor, Ryg, Schousboe, Schousboe, Schwartz, Shepherd, Siminoski, Siris, Siris, van Geel, Wasnich, Watts   +51 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Are We Making Progress? Assessing Goal-Directed Behaviors in Leadership Development Programs

Frontiers in Psychology, 2019
Leadership development programs increasingly help participants engage in their career transitions. Therefore, these programs lead participants to establish not only development goals, which usually involve the improvement of a specific leadership ...
Ferran Velasco, Joan Manuel Batista-Foguet, Robert J. Emmerling   +2 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source