Results 51 to 60 of about 475,793 (348)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Web Acceptance and Usage Model: A Comparison between Goal-directed and Experiential Web Users [PDF]

, 2005
In this paper we analyse the Web acceptance and usage between goal-directed users and experiential users, incorporating intrinsic motives to improve the particular and explanatory TAM value –traditionally related to extrinsic motives-.
Roldán Salgueiro, José Luis, Sánchez Franco, Manuel Jesús   +1 more
core  

The integrated theory of emotional behavior follows a radically goal-directed approach [PDF]

, 2017
status ...
Moors, Agnes
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Effect of hip CPM on gross motor function and development of the hip joint: a single-center randomized controlled study on spastic cerebral palsy children with hip dysplasia

Frontiers in Pediatrics, 2023
ObjectiveTo investigate the effectiveness of hip continuous passive motion (hCPM) on hip development at skeletal maturity and gross motor function for spastic cerebral palsy children with hip dysplasia.MethodsProspective case–control research of hCPM ...
Lulu Wang, Nuochen Zhang, Liwei Fang, Zhenzhen Cui, Huihui Niu, Fuli Lv, Dayong Hu, De Wu, De Wu   +8 more
doaj   +1 more source

Hippocampus and retrosplenial cortex combine path integration signals for successful navigation [PDF]

, 2013
The current study used fMRI in humans to examine goal-directed navigation in an open field environment. We designed a task that required participants to encode survey-level spatial information and subsequently navigate to a goal location in either first ...
Brown, Thackery I, Erdem, Ugur M., Hasselmo, Michael E., Ross, Robert S., Sherrill, Katherine R., Stern, Chantal E.   +5 more
core   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Goal-directed vocal planning in a songbird

eLife
Songbirds’ vocal mastery is impressive, but to what extent is it a result of practice? Can they, based on experienced mismatch with a known target, plan the necessary changes to recover the target in a practice-free manner without intermittently singing?
Anja T Zai, Anna E Stepien, Nicolas Giret, Richard HR Hahnloser   +3 more
doaj   +1 more source

Premotor cortex is critical for goal-directed actions

Frontiers in Computational Neuroscience, 2013
Shifting between motor plans is often necessary for adaptive behavior. When faced with changing consequences of one’s actions, it is often imperative to switch from automatic actions to deliberative and controlled actions. The presupplementary motor area
Christina eGremel, Rui eCosta, Rui eCosta   +2 more
doaj   +1 more source

Thalamo-Nucleus Accumbens Projections in Motivated Behaviors and Addiction

Frontiers in Systems Neuroscience, 2021
The ventral striatum, also called nucleus accumbens (NAc), has long been known to integrate information from cortical, thalamic, midbrain and limbic nuclei to mediate goal-directed behaviors.
Aurélie De Groote, Alban de Kerchove d’Exaerde   +1 more
doaj   +1 more source