Results 61 to 70 of about 425,428 (324)

Infants' mu suppression during the observation of real and mimicked goal-directed actions [PDF]

, 2013
Since their discovery in the early 1990s, mirror neurons have been proposed to be related to many social-communicative abilities, such as imitation. However, research into the early manifestations of the putative neural mirroring system and its role in ...
Handl, A, Pattyn, Griet, Roeyers, Herbert, Ruysschaert, Lieselot, Warreyn, Petra, Wiersema, Roeljan   +5 more
core   +1 more source

A multi-center, double-blind, placebo-controlled, randomized, parallel-group, non-inferiority study to compare the efficacy of goal-directed tranexamic acid administration based on viscoelastic test versus preemptive tranexamic acid administration on postoperative bleeding in cardiovascular surgery (GDT trial)

Trials
Background Tranexamic acid (TXA) effectively attenuates hyperfibrinolysis and preemptive administration has been employed to reduce bleeding and blood transfusions in various surgical settings. However, TXA administration could be associated with adverse
Jae-Sik Nam, Chung-Sik Oh, Ji-Yoon Kim, Dae-Kee Choi, Ah Ran Oh, Jungchan Park, Jong-Hwan Lee, Sung-Cheol Yun, Kyeng Whan Kim, Min Uk Jang, Tae-Yop Kim, In-Cheol Choi   +11 more
doaj   +1 more source

A closer look at the effects of repeated cocaine exposure on adaptive decision making under conditions that promote goal-directed control

Frontiers in Psychiatry, 2016
It has been proposed that compulsive drug seeking reflects an underlying dysregulation in adaptive behavior that favors habitual (automatic and inflexible) over goal-directed (deliberative and highly flexible) action selection.
Briac eHalbout, Angela T Liu, Sean B Ostlund   +2 more
doaj   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

Goal-Directed Behavior under Variational Predictive Coding: Dynamic Organization of Visual Attention and Working Memory

, 2019
Mental simulation is a critical cognitive function for goal-directed behavior because it is essential for assessing actions and their consequences. When a self-generated or externally specified goal is given, a sequence of actions that is most likely to ...
Jung, Minju, Matsumoto, Takazumi, Tani, Jun   +2 more
core   +1 more source

Goal-Directed Decision Making with Spiking Neurons. [PDF]

, 2015
UNLABELLED: Behavioral and neuroscientific data on reward-based decision making point to a fundamental distinction between habitual and goal-directed action selection.
Friedrich, Johannes, Lengyel, Máté
core   +2 more sources

The value of foresight: how prospection affects decision-making

Frontiers in Neuroscience, 2011
Traditional theories of decision-making assume that utilities are based on the intrinsic value of outcomes; in turn, these values depend on associations between expected outcomes and the current motivational state of the decision-maker.
Giovanni ePezzulo, Francesco eRigoli
doaj   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Condition interference in rats performing a choice task with switched variable- and fixed-reward conditions

Frontiers in Neuroscience, 2015
Because humans and animals encounter various situations, the ability to adaptively decide upon responses to any situation is essential. To date, however, decision processes and the underlying neural substrates have been investigated under specific ...
Akihiro eFunamizu, Akihiro eFunamizu, Makoto eIto, Kenji eDoya, Ryohei eKanzaki, Ryohei eKanzaki, Hirokazu eTakahashi, Hirokazu eTakahashi   +7 more
doaj   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source