Results 41 to 50 of about 179,728 (215)
The Person and the Challenges, 2015 During their existence, people often forget about the meaning of life. With the world spinning faster and faster, the disappearing ability to reflect on complex day-to- day life, the virtual reality and ‘the net’ jungle, people are forgetting how to ...
Michał Styczyński
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Attracting Human Resources to Arctic Enterprises Using Marketing Tools
Арктика и Север, 2020 In connection with the movement of various types of production in the Arctic region, it becomes necessary to attract human resources to new enterprises. In the article, we analyze the branding system in companies operating in the Arctic region, as one of
Sofya O. PUDOVKINA, Marina N. KRUK
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
ACQUISITION OF BASIC PUBLIC SPEAKING SKILLS
BizInfo, 2017 With this texst we show that the acquisition of oratorical skills means not only mastering certain techniques of oratory, or public speaking, but that this is largely primarily related with a kind of mental preparation of speakers themselves, or in which
Nataša Novaković, Boris Teodosijević
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Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
The application of and unresolved problems regarding the use of objectives in software engineering
Ingeniería e Investigación, 2012 One of the first items which should be identified in resolving a problem or need is an objective in the various fields of knowledge as it enables determining which results must be achieved.
Luis Alfonso Lezcano Rodríguez +2 more
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