Results 61 to 70 of about 654,111 (262)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Using Multi-Logistic Distribution and Stochastic Goal Programming for Estimating the Human Resources for Development Strategy [PDF]
المجلة المصرية للسکـان وتنظيم الأسرة, 2015 The main goal of this paper is to anticipate the expected estimates of the human resources to build up a development strategy of employment. Three methodological approaches were used to achieve this goal, the logistic distribution, Bayesian technique and
Zeinab Yousef Mahmoud
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
EIRP Proceedings, 2009 Sustainable development has become a political objective of the European Unionsince 1997 through its inclusion in the Maastricht Treaty. In 2001, the Gothenburg EuropeanCouncil adopted the Sustainable Development Strategy of the European Union, which had
Domnica Doina Parcalabu, Georgeta Modiga
doaj
INTEGRATION ANALYSIS OF THE ENTERPRISE'S EXTERNAL ENVIRONMENT AND INTERNAL CAPACITY
Вестник Северо-Кавказского федерального университета, 2022 The article sets as the goal on the basis of the integration analysis of the external environment and the internal capacity of the enterprise to develop a number of targets that can serve as the basis for the formation and subsequent implementation of ...
E. Depershmidt
doaj
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Frontiers in Psychology, 2019 The aim of this paper was to study the combined effects of tactical and contextual dimensions on achieving offensive performance in open play possessions from Spanish “La Liga” soccer matches.
Joaquín González-Rodenas +6 more
doaj +1 more source